Progress in moyamoya disease

Shang, Shuling; Zhou, Da; Ya, Jingyuan; Li, Sijie; Yang, Qi; Ding, Yuchuan; Ji, Xunming

doi:10.1007/s10143-018-0994-5

Cited by 95 publications

(102 citation statements)

References 104 publications

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“…Moyamoya disease is a rare, non-atherosclerotic arteriopathy characterised by progressive stenosis of the internal carotid arteries, ultimately leading to occlusion 15. The prevalence of moyamoya disease is higher in children and young adults than those aged 50 years or over and varies widely worldwide.…”

Section: Epidemiology and Stroke Aetiology From A Global Perspectivementioning

confidence: 99%

Ischaemic stroke in young adults: a global perspective

Boot¹,

Ekker²,

Putaala

et al. 2020

J Neurol Neurosurg Psychiatry

142

121

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Ischaemic stroke at young age is an increasing problem in both developing and developed countries due to rising incidence, high morbidity and mortality and long-term psychological, physical and social consequences. Compared with stroke in older adults, stroke in young adults is more heterogeneous due to the wide variety of possible underlying risk factors and aetiologies. In this review, we will provide an overview of the global variation in the epidemiology of stroke in young adults, with special attention to differences in geography, ethnicity/race and sex, as well as traditional and novel risk factors for early-onset ischaemic stroke, such as air pollution. Understanding global differences is an important prerequisite for better region-specific prevention and treatment of this devastating condition.

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Section: Epidemiology and Stroke Aetiology From A Global Perspectivementioning

confidence: 99%

Ischaemic stroke in young adults: a global perspective

Boot¹,

Ekker²,

Putaala

et al. 2020

J Neurol Neurosurg Psychiatry

142

121

View full text Add to dashboard Cite

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“…The smoke‐like vessels are fragile and thin, resulting in thrombosis formation and microaneurysm rupture, leading to cerebral ischemia and hemorrhage . Furthermore, lack of adequate blood flow can lead to cortical and subcortical ischemia, resulting in neurological deficits . Hence, improvement and restoration of CBF in moyamoya is a topic of ongoing interest.…”

Section: Discussionmentioning

confidence: 99%

“…Chronic cerebral circulation insufficiency in iMMD always causes nonfocal neurological deficits such as headache, dizziness, and insomnia; as a result, the subjective feelings from patients are of great importance. Therefore, PGIC scales, which reflected the emotional and patient‐subjective status, were used as the indicator for symptom amelioration in this study . Of the 30 patients, 29 noticed a benefit from RIC, while one patient experienced a minor stroke recurrence and his symptoms mildly fluctuated during the follow‐up period.…”

Section: Discussionmentioning

confidence: 99%

Remote ischemic conditioning for the treatment of ischemic moyamoya disease

et al. 2019

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Aims This study investigated the safety and efficacy of remote ischemic conditioning (RIC) on ameliorating the sequelae of ischemic moyamoya disease (iMMD). Methods A total of 30 iMMD patients underwent long‐term RIC and were followed up at 0.5, 1, and 2 years for clinical outcomes, including frequency of stroke recurrence, Patient Global Impression of Change (PGIC) scale, peak systolic velocities (PSV), and cerebral perfusion. Results During the whole RIC treatment process, no RIC‐related adverse event occurred. Only one of 30 patients suffered a onetime infarction (3.3%), and the ratios of acceptable PGIC were 88.2%, 64.3%, and 92.3% at 0.5, 1, and 2 years follow‐up. Kaplan‐Meier analysis showed the frequency of stroke recurrence was significantly reduced after RIC (P = .013). The frequency of TIA per week was 1.1 (0.6, 2.8) prior to RIC and 0.1 (0.0, 0.5) post‐RIC (P < .01). Compared to baseline, PSV values were significantly reduced after RIC treatment (P = .002 at 0.5, P = .331 at 1, and P = .006 at 2 years). In patients undergoing perfusion studies, 75% obtained improvement on followed‐up SPECT and 95% on followed‐up PET maps. Conclusions Remote ischemic conditioning may be beneficial on controlling iMMD‐induced ischemic events, relieving symptoms, and improving cerebral perfusion, without incidence of complications in this case series.

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“…Recent studies have investigated genetic, acquired, and environmental factors as causes of moyamoya disease, but no specific cause has yet been found (Shang et al, 2020). Vasodilator, anticoagulant, and hemostatic treatments are typically used, but there is no standard clinical treatment available, and while surgical methods such as direct and indirect revascularization are often used, medical professionals have not reached a consensus regarding the best options for adults with moyamoya disease (Ding et al, 2018; Ge et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Stress and mood of adults with moyamoya disease: A cross‐sectional study

Yang

Ryu

Yeom

et al. 2020

Nursing & Health Sciences

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Moyamoya disease in adults is a chronic, progressive disorder characterized by fine collateral vessel networks in the brain. The disorder can lead to negative mood and stress, which, left unresolved, may increase adverse health outcomes. We conducted a cross‐sectional survey to examine stress and mood of adults with moyamoya disease. Participants were recruited at a university hospital in Seoul, Korea. Data were collected through questionnaires and review of participants' electronic medical records. A total of 109 adults participated. Significant correlations were found between perceived stress, anxiety, and depression. Adults with moyamoya disease experience anxiety, depression, and stress related to the risk of cerebral hemorrhage or ischemia, similar to those with other cerebrovascular disease. If negative mood and stress were uncontrolled, those can cuase adverse health outcomes. Health professionals caring for people with moyamoya disease should carefully observe their stress and mood and develop interventions tailored to stages of disease to help them manage. The study results provide baseline information for understanding the level of, and the factors associated with, stress and mood.

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Progress in moyamoya disease

Cited by 95 publications

References 104 publications

Ischaemic stroke in young adults: a global perspective

Ischaemic stroke in young adults: a global perspective

Remote ischemic conditioning for the treatment of ischemic moyamoya disease

Stress and mood of adults with moyamoya disease: A cross‐sectional study

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