Progress in COVID research and developments during pandemic

Abstract

The pandemic respiratory disease COVID‐19 has spread over the globe within a small span of time. Generally, there are two important points are being highlighted and considered towards the successful diagnosis and treatment process. The first point includes the reduction of the rate of infections and the next one is the decrease of the death rate. The major threat to public health globally progresses due to the absence of effective medication and widely accepted immunization for the COVID‐19. Whereas, understanding of host susceptibility, clinical features, adaptation of COVID‐19 to new environments, asymptomatic infection is difficult and challenging. Therefore, a rapid and an exact determination of pathogenic viruses play an important role in deciding treatments and preventing pandemic to save the people's lives. It is urgent to fix a standardized diagnostic approach for detecting the COVID‐19. Here, this systematic review describes all the current approaches using for screening and diagnosing the COVID‐19 infectious patient. The renaissance in pathogen due to host adaptability and new region, facing creates several obstacles in diagnosis, drug, and vaccine development process. The study shows that adaptation of accurate and affordable diagnostic tools based on candidate biomarkers using sensor and digital medicine technology can deliver effective diagnosis services at the mass level. Better prospects of public health management rely on diagnosis with high specificity and cost‐effective manner along with multidisciplinary research, specific policy, and technology adaptation. The proposed healthcare model with defined road map represents effective prognosis system.

Emergence of integrated biosensing-enabled digital healthcare devices

“…191 Access to high-quality, cost-effective, and appropriate health products is crucial for advancing universal health coverage, addressing health emergencies, and promoting healthier populations, even during pandemics. 191,192 In recent decades, the sensor market in the healthcare sector has expanded significantly. Nanosensors developed by biomaterials can work efficiently in diagnostic devices for assessing anti-bacterial and anti-cancer activities based on electrochemistry communications.…”

Decoding Biomechanical Cues Based on DNA Sensors

“…Combined with the controllable multivalent topology of DNA nano-tetrahedra, Yanling Song et al achieved firm binding of the Virus to the TGT probe and constructed the virus-TGT platform (Figure 10D). [60] Different from the analysis mode of single-molecule force spectroscopy for individual receptor-ligand or ligand-cell interactions, [61] the Virus-TGT platform allows for the measurement of overall mechanical forces between SARS-CoV-2 [62] and host cells and reveals the relationship between virus-cell mechanical forces and infectivity.…”

The relation between covid-19 disease and voice disorders

“…Brza i masovna orijentacija istraživača na COVID-19 postala je očita u naglom skoku broja istraživačkih priloga koji se njime bave u etabliranim bazama znanstvenih radova. 2 Usprkos tome, utjecaj COVID-19 na specifične tjelesne sustave poput fonatornog i danas nije moguće metodološki rigorozno sumirati zbog premalog broja prijavljenih znanstvenih priloga koji ih obrađuju, nego ih se prikazuje tek kao preliminarne preglede spoznaja. Cilj ovoga rada upravo je dati takav pregled spoznaja o fonijatrijskim posljedicama COVID-19 temeljem pregleda baza podataka Scopus, Medline, Current Contents i PsycInfo pomoću ključnih riječi "COVID-19" i "disfonija".…”