Biochemical Pharmacology volume 82, issue 8, P862-872 2011 DOI: 10.1016/j.bcp.2011.06.022 View full text
Sharon R. Letchworth, Paul Whiteaker

Abstract: Recent progress has been made in the understanding of the anatomical distribution, composition, and physiological role of nicotinic acetylcholine receptors containing the α6 subunit. Extensive study by many researchers has indicated that a collection of α6-containing receptors representing a nicotinic sub-family is relevant in preclinical models of nicotine self-administration and locomotor activity. Due to a number of technical difficulties, the state of the art of in vitro model systems expressing α6-contai…

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