Progress and Challenges in Pharmacogenomics

Driest, Sara L. Van; Cascorbi, Ingolf

doi:10.1002/cpt.2359

Cited by 3 publications

(3 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Individual responses to a drug vary greatly in terms of both efficacy and toxicity. Pharmacogenomics is the research examining the impact of individual genetic makeup on drug response variability [59]. The composition of the gut microbiota shows high inter-individual variation.…”

Section: Drugs Mediate Gut Microbiotamentioning

confidence: 99%

The changes of gut microbiota and metabolites in different drug-induced liver injuries

Zhu,

Gao,

Dong

et al. 2023

Journal of Medical Microbiology

View full text Add to dashboard Cite

The increasing incidence of drug-induced liver injury (DILI) has become a major concern. Gut microbiota, as another organ of the human body, has been studied in various tumors, cardiovascular metabolic diseases, inflammatory bowel disease and human immunity. The studies mentioned above have confirmed its important impact on the occurrence and development of DILI. The gut-liver axis explains the close relationship between the gut and the liver, and it may be a pathway by which gut microbes contribute to DILI. In addition, the interaction between drugs and gut microbes affects both separately, which in turn may have positive or negative effects on the body, including DILI. There are both common and specific changes in liver injury caused by different drugs. The alteration of metabolites in DILI is also a new direction of therapeutic exploration. The application of microbiomics, metabolomics and other multi-omics to DILI has also explored new ideas for DILI. In this review, we conclude the alterations of gut microbes and metabolites under different DILI, and the significance of applying gut microbiome-metabolomics to DILI, so as to explore the metabolic characteristics of DILI and possible novel metabolic biomarkers.

show abstract

Section: Drugs Mediate Gut Microbiotamentioning

confidence: 99%

The changes of gut microbiota and metabolites in different drug-induced liver injuries

Zhu,

Gao,

Dong

et al. 2023

Journal of Medical Microbiology

View full text Add to dashboard Cite

show abstract

“…Furthermore, contributions for themed issues are no longer by invitation only and open calls for papers are now being issued. Six themed issues have been published using this new format in the last 2 years, 3–8 and 3 are scheduled for publication in 2022 ( Table 1 ). Submissions for the “Transporter” theme (scheduled for publication in September 2022) are still being accepted.…”

Section: Figurementioning

confidence: 99%

Themes in Clinical Pharmacology and Therapeutics

Graaf

Gerding

2021

Clin Pharma and Therapeutics

View full text Add to dashboard Cite

“…During past few decades there has been a huge progress in the discovery of genetic basis of many diseases and the development of new diagnostic and screening tests, as well as new drug therapies which become widely available to the public. While such progress has allowed the rapid development of personalized and precision medicine (Olson et al, 2014;Annaratone et al, 2021) it was closely related to recent advances in pharmacogenetics and pharmacogenomics, that have been revolutionized after the human genome, among other species, has been sequenced and publicized, allowing identification of numerous genetic biomarkers associated with either positive or adverse drug responses (Sadee, 2017;Van Driest and Cascorbi, 2021). In large part this progress is due to the development of research biobanks, i.e., collections of human biospecimens and associated health, medical, nutrition, lifestyle and environmental information, which enable researchers wide access to well-annotated patient samples (McCarty and Wilke, 2010;Olson et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Do biobanks need pharmacists? Support of pharmacy students to biobanking of human biological material for pharmaceutical research and development

Domaradzki,

Majchrowska,

Cielecka-Piontek

et al. 2024

Front. Pharmacol.

View full text Add to dashboard Cite

Objectives:This study aimed to assess the biobank awareness among Polish pharmacy students and how it affects their support for biobank research.Methods:A survey among 366 pharmacy students enrolled at two Polish medical universities: the Poznań University of Medical Sciences and Medical University of Lublin was conducted.Results:Although most pharmacy students felt positivity about biobanking and expressed the willingness to donate their biospecimens for biomedical research, their awareness on research biobanks was low. Their willingness to participate was driven by the desire to benefit society, help advance science and develop new therapies. While students supported donation for most types of research, biobanks run by medical universities were the highest trusted research institutions. The primary factors associated with student’s willingness to participate were religiosity and place of study. Notably, nonreligious students and those studying in Poznan exhibited more favourable attitudes toward donating for research and expressed greater support for the establishment of research biobanks in Poland.Conclusion:Since biobank awareness among future pharmacists is inadequate incorporating biobank competency domains into education and training of pharmacists is required.

show abstract

Progress and Challenges in Pharmacogenomics

Cited by 3 publications

References 16 publications

The changes of gut microbiota and metabolites in different drug-induced liver injuries

The changes of gut microbiota and metabolites in different drug-induced liver injuries

Themes in Clinical Pharmacology and Therapeutics

Do biobanks need pharmacists? Support of pharmacy students to biobanking of human biological material for pharmaceutical research and development

Contact Info

Product

Resources

About