Programmed cell death in cerebellar Purkinje neurons

Erekat, Nour S.

doi:10.31083/j.jin2101030

Cited by 14 publications

(10 citation statements)

References 168 publications

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“…In the second stage, nuclear fragments, combine with various cellular organelles, and are further enveloped by the plasma membrane to form apoptotic bodies. In the third stage, phagocytes engulf and digest the apoptotic bodies, recycling their components for reuse by the organism 10,11 . Apoptosis can occur through two main pathways: the extrinsic pathway (death receptor‐mediated) and the intrinsic pathway (mitochondria‐mediated) 12 .…”

Section: Overview Of Apoptosismentioning

confidence: 99%

“…In the third stage, phagocytes engulf and digest the apoptotic bodies, recycling their components for reuse by the organism. 10 , 11 Apoptosis can occur through two main pathways: the extrinsic pathway (death receptor‐mediated) and the intrinsic pathway (mitochondria‐mediated). 12 The extrinsic pathway involves cell death mediated by transmembrane receptors (e.g., the tumour necrosis factor TNF receptor superfamily.…”

Section: Overview Of Apoptosismentioning

confidence: 99%

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The role of programmed cell death in diabetic foot ulcers

Li,

Jiang,

Xia

2023

International Wound Journal

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Diabetic foot ulcer, is a chronic complication afflicting individuals with diabetes, continue to increase worldwide, immensely burdening society. Programmed cell death, which includes apoptosis, autophagy, ferroptosis, necroptosis and pyroptosis, has been increasingly implicated in the pathogenesis of diabetic foot ulcer. This review is based on an exhaustive examination of the literature on ‘programmed cell death’ and ‘diabetic foot ulcers’ via PubMed. The findings revealed that natural bioactive compounds, noncoding RNAs and certain proteins play crucial roles in the healing of diabetic foot ulcers through various forms of programmed cell death, including apoptosis, autophagy, ferroptosis and pyroptosis.

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Section: Overview Of Apoptosismentioning

confidence: 99%

Section: Overview Of Apoptosismentioning

confidence: 99%

The role of programmed cell death in diabetic foot ulcers

Li,

Jiang,

Xia

2023

International Wound Journal

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“…Apoptosis is also called type I programmed cell death [ 32 ]. It is morphologically characterized by cell shrinkage, chromatin condensation, nuclear deoxyribonucleic acid (DNA) fragmentation, and the formation of apoptotic bodies, which are eventually removed via phagocytosis, preventing the elicitation of any inflammation [ 33 – 35 ].…”

Section: Apoptosismentioning

confidence: 99%

Programmed Cell Death in Diabetic Nephropathy: A Review of Apoptosis, Autophagy, and Necroptosis

Erekat

2022

Med Sci Monit

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Diabetic nephropathy is a common complication of type I and type II diabetes, in which renal glomeruli are destroyed, resulting in renal damage, proteinuria, and hypertension. Apoptosis, autophagy, and necroptosis are 3 forms of programmed cell death that have been implicated in the pathogenesis of diabetic nephropathy. Apoptosis of podocytes leads to glomerular injury and podocyte depletion, which are associated with proteinuria and glomerular structural damage in diabetic nephropathy. Additionally, epithelial cells in the proximal convoluted tubules also undergo apoptosis in diabetic nephropathy, leading to tubular atrophy, which causes tubular cell depletion and the subsequent formation of atubular glomeruli in association with the loss of renal function. On the other hand, insufficiency of autophagy has been correlated with the pathogenesis of diabetic nephropathy. For instance, decreased autophagic activity has been shown in podocytes of the diabetic kidney, causing variations in podocyte function and subsequent disruption to the glomerular filtration barrier. Furthermore, attenuated autophagic activity has also been demonstrated in proximal tubular cells of the diabetic kidney, resulting in the buildup of impaired molecules and organelles, which are normally broken down by autophagy, leading to proteinuria. Moreover, necroptosis might have a key role in podocyte damage and subsequent decline in diabetic nephropathy. Thus, this article aims to review the mechanisms and effects of programmed cell death in diabetic nephropathy, including the roles of apoptosis, autophagy, and necroptosis.

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“…Autophagy is classified into three types, which are: macroautophagy, microautophagy, and chaperone-mediated autophagy (CMA) [ 11 ]. Macroautophagy is possibly the best-described type of autophagy, and it is referred to as autophagy throughout this review [ 20 , 21 ].…”

Section: Autophagymentioning

confidence: 99%

“…Autophagy is a form of programmed cell death that is required for the turnover of long-lived organelles and elimination of impaired proteins [ 11 ]. Impaired autophagy has been shown to be involved in the pathogenesis of Parkinson disease, since it can lead to disrupted elimination of α-synuclein, resulting in its build up and subsequent misfolding [ 12 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

Autophagy and Its Association with Genetic Mutations in Parkinson Disease

Erekat

2022

Med Sci Monit

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Parkinson disease is the second most common neurodegenerative disorder, affecting 0.1–0.2% of the general population. It is a progressive debilitating disorder caused by degeneration of dopaminergic neurons in the substantia nigra pars compacta. It is characterized by motor and non-motor symptoms. Parkinson disease can be caused by mutations in genes that encode proteins involved in the autophagic process, resulting in impaired autophagy. Indeed, autophagy has been implicated in the pathogenesis of Parkinson disease, particularly because its impairment causes the buildup of proteins. Thus, this review aims to provide an overview of Parkinson disease-related genetic mutations and their association with autophagy impairment in Parkinson disease, which can be helpful in improving the understanding of the pathogenesis of Parkinson disease, illustrating the potential therapeutic implications of agents that can enhance autophagy in Parkinson disease. Additionally, we will highlight the essential need for the development of highly sensitive and specific assays for gene-based diagnostic biomarkers. Finally, we will provide an overview on the potential gene-based therapeutic approaches for Parkinson disease, which have been most advanced and are associated with the most common targets being alpha-synuclein (SNCA), leucine-rich repeat kinase-2 (LRRK2), and glucocerebrosidase (GBA).

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Programmed cell death in cerebellar Purkinje neurons

Cited by 14 publications

References 168 publications

The role of programmed cell death in diabetic foot ulcers

The role of programmed cell death in diabetic foot ulcers

Programmed Cell Death in Diabetic Nephropathy: A Review of Apoptosis, Autophagy, and Necroptosis

Autophagy and Its Association with Genetic Mutations in Parkinson Disease

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