Programa de Prevención Secundaria de la Arteriosclerosis de un hospital universitario. Resultados y factores predictivos del curso clínico

Pintó, Xavier; Meco, José; Corbella, Emili; Figueras, R.; Pallarés, Carlos; Esplugas, Enric; Castiñeiras, M J; Marrugat, Jaume; Pujol, R.

doi:10.1157/13048328

Cited by 7 publications

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“…With regard to identifying the "best" lipoprotein ratio, there is an interesting contrast between the use of cut-off points 46 and quantiles. 50 Thus it must be taken into account that while cut-off points can provide clinical relevant information, with regard to comparing ratios it would seem more logical to use quantiles within the cohort/population.…”

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confidence: 99%

Lipoprotein ratios: Physiological significance and clinical usefulness in cardiovascular prevention

Millán

Pintó²,

Muñoz³

et al. 2009

VHRM

314

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Low-density lipoprotein (LDL) cholesterol concentration has been the prime index of cardiovascular disease risk and the main target for therapy. However, several lipoprotein ratios or "atherogenic indices" have been defined in an attempt to optimize the predictive capacity of the lipid profile. In this review, we summarize their pathophysiological aspects, and highlight the rationale for using these lipoprotein ratios as cardiovascular risk factors in clinical practice, specifying their cut-off risk levels and a target for lipid-lowering therapy. Total/high-density lipoprotein (HDL) cholesterol and LDL/HDL cholesterol ratios are risk indicators with greater predictive value than isolated parameters used independently, particularly LDL. Future recommendations regarding the diagnosis and treatment of dyslipidemia, including instruments for calculating cardiovascular risk or action guidelines, should include the lipoprotein ratios with greater predictive power which, in view of the evidence-based results, are none other than those which include HDL cholesterol.

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confidence: 99%

Lipoprotein ratios: Physiological significance and clinical usefulness in cardiovascular prevention

Millán

Pintó²,

Muñoz³

et al. 2009

VHRM

314

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“…We planned to randomise a minimum of 60 patients in each group based on the following criteria: alpha error = 0.05, power = 80%, intervention/control ratio 1:1, 15% of potential dropouts, and assuming that 50% of control group patients would achieve the risk factor goal versus 80% of the intervention group. 16…”

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confidence: 99%

Secondary prevention programme of ischaemic heart disease in the elderly: A randomised clinical trial

Marcos-Forniol

Meco

Corbella

et al. 2017

Eur J Prev Cardiolog

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Background Elderly patients have been underrepresented in secondary cardiovascular prevention programmes. This study aimed to ascertain the effects of a secondary coronary disease prevention programme in these patients. Design Open randomised intervention study with parallel groups. Methods One hundred and twenty-seven patients aged ≥70 years with a recent acute coronary syndrome were randomised to a protocolised clinical intervention plus usual care (intervention group, n = 64) or to usual care alone (control group, n = 63). Patients were assessed at baseline and after 12 months. The main outcome was the percentage of patients with optimal risk factor control after 12 months of follow-up. Secondary outcomes included changes in Mediterranean diet adherence, quality of life and functionality. Mortality was evaluated three years after the end of the intervention. Results One hundred and six patients (83.4%) completed 12 months of follow-up (54 in the intervention group and 52 in the control group). At the end of intervention, 34.2% more patients in the intervention group had achieved optimal risk factor control with a number needed to treat of 3 (relative risk 2.18, 95% confidence interval 1.36 to 3.50). The intervention group improved adherence to the Mediterranean diet ( p = 0.013) and functionality assessed by the Short Physical Performance Battery ( p = 0.047). No differences between groups were found in quality of life (Short-Form 36 Health Survey) or mortality after three years (hazard ratio 1.19, 95% confidence interval 0.41 to 3.45). Conclusions A secondary coronary disease prevention programme in elderly patients with a recent acute coronary syndrome improved risk factor control, Mediterranean diet adherence and functionality.

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El largo trecho para llegar a los objetivos en el tratamiento de las dislipemias

Pintó

2012

Revista Clínica Española

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Programa de Prevención Secundaria de la Arteriosclerosis de un hospital universitario. Resultados y factores predictivos del curso clínico

Cited by 7 publications

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Lipoprotein ratios: Physiological significance and clinical usefulness in cardiovascular prevention

Lipoprotein ratios: Physiological significance and clinical usefulness in cardiovascular prevention

Secondary prevention programme of ischaemic heart disease in the elderly: A randomised clinical trial

El largo trecho para llegar a los objetivos en el tratamiento de las dislipemias

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