Prognostic value of microRNA-100 in esophageal squamous cell carcinoma

Zhou, Shu; Yang, Benqiang; Zhao, Yanjuan; Xu, Sen; Zhang, Hongwei; Li, Zhao

doi:10.1016/j.jss.2014.07.005

Cited by 17 publications

(17 citation statements)

References 21 publications

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“…Expression of hsa‐mir‐223 was also markedly increased . Hsa‐mir‐100 and hsa‐mir‐133b were notably downregulated in tumor tissues compared to normal tissues. Collectively, these results conclusively demonstrate that compared with adjacent noncancerous tissues, these five miRNAs show significantly different expression in esophageal cancer tissues.…”

Section: Resultsmentioning

confidence: 95%

Clinical value of integrated‐signature miRNAs in esophageal cancer

Zhang

Tang

2017

Cancer Medicine

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MicroRNAs (miRNAs) are crucial regulators of gene expression in tumorigenesis and are of great interest to researchers, but miRNA profiles are often inconsistent between studies. The aim of this study was to confirm candidate miRNA biomarkers for esophageal cancer from integrated‐miRNA expression profiling data and TCGA (The Cancer Genome Atlas) data in tissues. Here, we identify five significant miRNAs by a comprehensive analysis in esophageal cancer, and two of them (hsa‐miR‐100‐5p and hsa‐miR‐133b) show better prognoses with significant difference for both 3‐year and 5‐year survival. Additionally, they participate in esophageal cancer occurrence and development according to KEGG and Panther enrichment analyses. Therefore, these five miRNAs may serve as miRNA biomarkers in esophageal cancer. Analysis of differential expression for target genes of these miRNAs may also provide new therapeutic alternatives in esophageal cancer.

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Section: Resultsmentioning

confidence: 95%

Clinical value of integrated‐signature miRNAs in esophageal cancer

Zhang

Tang

2017

Cancer Medicine

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“…The prognostic value of miRNAs has been widely investigated. For example, miR-21, miR-29c, miR-148, miR-203, miR-100, miR-195, miR-335 and miR-503 can serve as promising prognostic biomarkers in oesophageal cancer ( Zhou et al , 2014 ; Sun et al , 2014a ; Zhang et al , 2014a ; Hezova et al , 2015 ; Ide et al , 2015 ). In this article, we detect the miR-146a prognostic value with FFPE tissue samples.…”

Section: Discussionmentioning

confidence: 99%

Prognostic and diagnostic potential of miR-146a in oesophageal squamous cell carcinoma

et al. 2016

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Background:Accumulating evidence indicates that dysregulated microRNA-146a (miR-146a) is involved in tumour genesis and cancer progression. We aimed to evaluate its expression level and the potential for the diagnosis and prognosis in oesophageal squamous cell cancer (ESCC).Methods:We examined miR-146a expression in 62 pairs of ESCC cancerous and matched paracancerous tissue, 115 formalin-fixed paraffin-embedded (FFPE) tissue samples and serum samples from 154 ESCC patients and 154 healthy volunteers using quantitative reverse transcription–PCR (qRT–PCR). Kaplan–Meier method, Cox regression and receiver-operating characteristic (ROC) curve analysis were applied to analyse its prognostic and diagnostic value.Results:MicroRNA-146a expression level was significantly decreased in ESCC tissue compared with paracancerous tissue (P<0.001). Its regulation level was negatively associated with T factor and TNM stage. Kaplan–Meier curve revealed that its downregulation level predicted worse overall survival (OS) and progression-free survival (PFS). Both univariate and multivariate analyses identified miR-146a expression as independent prognostic factor for OS and PFS. Serum miR-146a was significantly reduced in ESCC patients than in healthy controls (P<0.001). Area under the curve ROC value, sensitivity and specificity for this marker were 0.863±0.033, 85.7% and 68.6% in the Discovery Group, and 0.891±0.027, 82.1% and 83.3% in the Validation Group.Conclusions:MicroRNA-146a is significantly reduced in cancerous tissue and serum samples of ESCC patients. It is an ideal biomarker for the prognosis and diagnosis of ESCC.

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“…Wang et al showed that down-regulation of miR-100 in bladder cancer tissues was associated with shorter overall survival and poor progressionfree survival of patients [51]. In addition, by detecting the expression of miR-100 in 120 self-paired specimens of ESCC and adjacent normal tissues by RT-PCR, Zhou et al found that the expression of miR-100 in ESCC tissues was significantly lower than that in the adjacent normal tissues and could predict advanced clinical stage, depth of tumor invasion, and the presence of distant metastasis [31]. In CRC, low miR-100 expression was observed to be significantly connected with advanced TNM stage, larger tumor size, and higher incidence of lymph node metastasis, together with shorter overall survival, suggesting that miR-100 could serve as an independent unfavorable prognostic predictor [71].…”

Section: Mir-100 In Cancer Diagnosis and Prognosismentioning

confidence: 99%

Multiple Roles of MicroRNA-100 in Human Cancer and its Therapeutic Potential

Li¹,

Gao²,

Zhang³

et al. 2015

Cell Physiol Biochem

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MicroRNAs (miRNAs) are a recently discovered class of endogenous, small (about 22 nucleotides) non-coding RNAs, which play important roles in cancer development and progression. Emerging evidence shows that microRNAs exert their regulatory effects by directly binding to the 3'- untranslated regions (UTRs) of their target genes. MicroRNA-100 (miR-100) is aberrantly expressed and functions in many human cancers by regulating multiple cell processes, such as cell cycle, proliferation, differentiation, migration, invasion and apoptosis, via post-transcriptionally regulating various target genes. A better understanding of the molecular mechanisms involved in miR-100-mediated tumor progression will provide an opportunity for exploring novel miR-100-based targeted therapies for human cancers. This review aims to summarize the recently published literature on the roles of miR-100 in regulating tumorigenesis, and explore its potential clinical applications for cancer diagnosis, prognosis and clinical treatment.

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Prognostic value of microRNA-100 in esophageal squamous cell carcinoma

Cited by 17 publications

References 21 publications

Clinical value of integrated‐signature miRNAs in esophageal cancer

Clinical value of integrated‐signature miRNAs in esophageal cancer

Prognostic and diagnostic potential of miR-146a in oesophageal squamous cell carcinoma

Multiple Roles of MicroRNA-100 in Human Cancer and its Therapeutic Potential

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