2003
DOI: 10.1164/rccm.200302-219oc
|View full text |Cite
|
Sign up to set email alerts
|

Abstract: Exercise-induced hypoxia is an index of the severity of interstitial lung disease. We hypothesized that desaturation during a 6-minute walk test would predict mortality for patients with usual interstitial pneumonia (n = 83) and nonspecific interstitial pneumonia (n = 22). Consecutive patients with biopsy-proven disease performed a 6-minute walk test between January 1996 and December 2001. Desaturation was defined as a fall in oxygen saturation to 88% or less during the 6-minute walk test. Desaturation was com… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

15
348
2
16

Year Published

2006
2006
2016
2016

Publication Types

Select...
6
2

Relationship

0
8

Authors

Journals

citations
Cited by 450 publications
(381 citation statements)
references
References 51 publications
15
348
2
16
Order By: Relevance
“…This finding is significant, as 6MW test performance has been correlated with risk of mortality in other vulnerable populations. 6MW distance less than 475 m was predictive of death or lung transplant in a cohort of adults with cystic fibrosis (48), and desaturation during the 6MW test was predictive of mortality among patients with idiopathic interstitial pneumonia (49).…”
Section: Discussionmentioning
confidence: 95%
“…This finding is significant, as 6MW test performance has been correlated with risk of mortality in other vulnerable populations. 6MW distance less than 475 m was predictive of death or lung transplant in a cohort of adults with cystic fibrosis (48), and desaturation during the 6MW test was predictive of mortality among patients with idiopathic interstitial pneumonia (49).…”
Section: Discussionmentioning
confidence: 95%
“…Use of control dogs of same breed and age group is necessary to rule out confounding factors and to have more comparable results of exercise performance between diseased and healthy animals. Oxygen desaturation in 6MWT increases the risk of death in human IPF patients 21. Previous studies on dogs have reported a difference in oxygen saturation between healthy dogs and dogs with pulmonary disease15 as well as postwalking oxygen desaturation in a group of old healthy beagles.…”
Section: Discussionmentioning
confidence: 98%
“…Pa,O 2 f7.32 kPa (55 mmHg) is usually considered clinically significant, and may limit exercise tolerance with the potential to endanger the subject. This is seen in most patients with ILD and PVD, in many patients with moderate and severe COPD [50][51][52][53][54], and less frequently in patients with intracardiac left-to-right shunting or chronic heart failure [4]. Interestingly, it can also be seen in elite endurance athletes (see supplementary material, 1.8).…”
Section: Pulmonary Gas Exchange Abnormalitiesmentioning
confidence: 99%
“…Most patients with moderate or severe pulmonary fibrosis show arterial desaturation during exercise [51,52,119]. Measuring the work-rate at which desaturation emerges may be of interest for patient counselling on demanding physical activities or for deciding the prescription of ambulatory oxygen therapy.…”
Section: Arterial Oxygen Desaturationmentioning
confidence: 99%
See 1 more Smart Citation