2021
DOI: 10.1016/j.ejrad.2021.109612
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Abstract: To evaluate the prognostic role of chest computed tomography (CT), alone or in combination with clinical and laboratory parameters, in COVID-19 patients during the first peak of the pandemic. Methods: A retrospective single-center study of 301 COVID-19 patients referred to our Emergency Department (ED) from February 25 to March 29, 2020. At presentation, patients underwent chest CT and clinical and laboratory examinations. Outcomes included discharge from the ED after improvement/recovery (positive outcome), o… Show more

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Cited by 19 publications
(17 citation statements)
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References 50 publications
(64 reference statements)
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“…Early signs of gas exchange deficits in patients who later develop severe COVID-19—such as regional ventilation/perfusion (V/Q) heterogeneity and reduced lung gas volumes—have been inferred from chest imaging [ 5 , 14 , 15 ]; however, functional evidence of this notion is limited. Here, we show that breath-holding unmasks a greater COVID-19-related decline in gas exchange in those who progress to severe disease versus those who do not.…”
Section: Discussionmentioning
confidence: 99%
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“…Early signs of gas exchange deficits in patients who later develop severe COVID-19—such as regional ventilation/perfusion (V/Q) heterogeneity and reduced lung gas volumes—have been inferred from chest imaging [ 5 , 14 , 15 ]; however, functional evidence of this notion is limited. Here, we show that breath-holding unmasks a greater COVID-19-related decline in gas exchange in those who progress to severe disease versus those who do not.…”
Section: Discussionmentioning
confidence: 99%
“…Favorable outcomes of serious cases rely on judicious administration of ventilatory support for those likely to benefit most [ 3 ], but such resources have become uniquely limited during peaks in the pandemic. While known risk factors for adverse outcomes include older age [ 2 , 4 – 7 ], lower baseline pulse oxygen saturation (SpO 2 ) [ 5 , 7 , 8 ], obesity [ 4 ], cardiovascular comorbidities [ 4 – 6 ], and inflammatory biomarkers (e.g. C-reactive protein [ 6 ]), considerable unexplained heterogeneity remains [ 5 , 9 ].…”
Section: Introductionmentioning
confidence: 99%
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