Prognostic value of combined preoperative fibrinogen and neutrophil-lymphocyte ratio in patients with hepatocellular carcinoma after liver transplantation

Fu, Shun; Ji, Fei; Han, Ming; Chen, Maogen; Wang, Xiaoping; Ju, Wei; Zhao, Qiang; Wu, Lin; Ren, Qingyun; Guo, Zhi; Wang, Dong Ping; Zhu, Xiao Feng; Ma, Yi; He, Xiao Shun

doi:10.18632/oncotarget.13804

Cited by 23 publications

(24 citation statements)

References 37 publications

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“…Similarly, the 1-, 3-and 5-year recurrence-free survival rate in high versus low NLR group was 65.3, 48.5 and 39.4 versus 80.0, 68.0 and 65.2%. The difference was also significant as reflected by p = 0.013 [41]. Further, NLR was an independent prognostic factor for overall and recurrence-free survival after liver transplantation for HCC as was shown by multivariate analysis of 160 Western patients [42].…”

Section: Neutrophil-to-lymphocyte Ratio In Patients Receiving Transplmentioning

confidence: 75%

“…NLR has been included in the MORAL scores to predict recurrence after liver transplantation, and these scores were superior to Milan criteria [46]. Complex evaluation of NLR along with fibrinogen increases the prognostic accuracy in order to predict disease-free survival and overall survival in HCC patients treated by liver transplantation [41]. Pretransplantation NLR along with levels of C-reactive protein has been combined with Milan criteria to develop new selection criteria for living donor liver transplantation beyond Milan criteria [47].…”

Section: Neutrophil-to-lymphocyte Ratio In Patients Receiving Transplmentioning

confidence: 99%

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Innovative Blood Tests for Hepatocellular Carcinoma: Liquid Biopsy and Evaluation of Systemic Inflammatory Reaction

Štrumfa¹,

Mezale²,

Strumfs³

et al. 2018

Hepatocellular Carcinoma - Advances in Diagnosis and Treatment

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Hepatocellular carcinoma (HCC) is an aggressive tumour associated with dismal prognosis. To improve the outcome, early diagnostics is important. At present, classical HCC diagnostics is based on evaluation of risk factors, surveillance in cirrhotic patients, preference for non-invasive diagnosis by computed tomography or magnetic resonance imaging and biopsy confirmation in controversial cases. However, ambiguous radiological presentation, biopsy-related complications or insufficient representation of the pathology in the tissue core are well-known problems. Panel assessment of microRNAs has diagnostic and prognostic value; thus, in future, microRNA-based liquid biopsy could partially reduce the need for core biopsies. Systemic inflammatory reaction (SIR), characterised mainly by neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio and Glasgow prognostic score, may have prognostic value and can be incorporated in criteria for certain treatment approaches, e.g., becoming an adjunct to Milan criteria. Thus, innovations in HCC diagnostics are expected in the field of miRNA-based liquid biopsy for diagnosis/prognosis and SIR for prognosis/selection of treatment.

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Section: Neutrophil-to-lymphocyte Ratio In Patients Receiving Transplmentioning

confidence: 75%

Section: Neutrophil-to-lymphocyte Ratio In Patients Receiving Transplmentioning

confidence: 99%

Innovative Blood Tests for Hepatocellular Carcinoma: Liquid Biopsy and Evaluation of Systemic Inflammatory Reaction

Štrumfa¹,

Mezale²,

Strumfs³

et al. 2018

Hepatocellular Carcinoma - Advances in Diagnosis and Treatment

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show abstract

“…Finally, we identified 15 studies, all published between 2008 and 2018, which met the inclusion criteria. [16][17][18][19][20][21][22][23][24][25][26][27][28][29][30] Of the 15 studies, 12 were retrospective cohort studies 16-22, 24-27, 29 and three were case-control studies 23,28,30 (Table S2). Among the 12 cohort studies, nine were from China, one from England, one from Korea and one from Thailand.…”

Section: Search Results Study Characteristic and Quality Assessmentmentioning

confidence: 99%

Preoperative neutrophil-lymphocyte ratio predicts the risk of microvascular invasion in hepatocellular carcinoma: A meta-analysis

Zeng

Chen²,

Zeng

et al. 2019

Int J Biol Markers

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Background: Preoperative estimation of microvascular invasion is of great significance for the clinical decision making in hepatocellular carcinoma. Neutrophil-lymphocyte ratio (NLR) has been reported to be correlated with the poor prognosis of hepatocellular carcinoma. However, the conclusions are conflicting on whether high preoperative NLR level is associated with the presence of microvascular invasion. Aim: To evaluate the association between preoperative NLR level and the risk of microvascular invasion in hepatocellular carcinoma. Methods: Relevant studies were identified by searching PubMed and Embase through February 2019. Fixed or random models were applied to analyze the data based on the heterogeneity. Subgroup, sensitivity, and publication bias analyses were performed. Review Manager 5.3 and STATA software were used for the meta-analysis. Results: A total of 15 studies were eventually included in this meta-analysis. Pooled data based on retrospective cohort studies showed there are more hepatocellular carcinoma patients with vascular invasion (OR 1.74; 95% Cl 1.42, 2.12; P < 0.001) and microvascular invasion (OR 1.62 95% Cl 1.39, 1.89; P < 0.001) in the high NLR group than in the low NLR group. Of case-control studies, a higher preoperative NLR level was found in the microvascular invasion positive group than in the microvascular invasion negative group (OR 0.62; 95% Cl 0.35, 0.90; P < 0.001). The subgroup, sensitivity, and publication bias analyses did not change the results. Conclusion: A higher preoperative NLR level is positively correlated with the risk of microvascular invasion in hepatocellular carcinoma.

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“…Researchers have expressed increasing interest in the role of systemic inflammation as a predictor of outcomes in patients with HCC. An elevated pretreatment neutrophil-to-lymphocyte ratio (NLR) is confirmed to be associated with poor outcomes in patients with HCC [32]. The platelet-to-lymphocyte ratio (PLR) is also reported to be associated with the outcomes of HCC [33].…”

Section: Introductionmentioning

confidence: 99%

Inflammation scores predict the survival of patients with hepatocellular carcinoma who were treated with transarterial chemoembolization and recombinant human type-5 adenovirus H101

Lin

2017

PLoS ONE

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BackgroundThe systemic inflammatory response plays an important role in cancer development and progression. An original inflammation-based staging system for predicting survival in patients undergoing transarterial chemoembolization (TACE) combined with recombinant human type-5 adenovirus H101 is not available. This study aimed to validate the prognostic value of inflammation scores for patients with hepatocellular carcinoma (HCC) who were treated with TACE combined with H101.MethodsThe data from 216 patients with HCC who underwent TACE combined with H101 from January 2007 to July 2015 were retrospectively collected, and the association of the inflammation scores with overall survival (OS) was analyzed. Univariate and multivariate analyses were performed to identify variables associated with OS. The prognostic value of the inflammation scores, including the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), neutrophil/ platelet-to-lymphocyte ratio (NLR-PLR), modified Glasgow Prognostic Score (mGPS), prognostic nutritional index (PNI), prognostic index (PI), tumor-node-metastasis (TNM), Barcelona Clinic Liver Cancer (BCLC) and Cancer of the Liver Italian Program (CLIP) staging systems were analyzed and compared using the areas under the receiver operating characteristic curves (AUROCs).ResultsThe estimated 1-, 2-, and 3-year OS rates were 61.3%, 44.2%, and 40.5% for the entire study cohort, respectively; the median OS was 17 months. According to the multivariate Cox proportional hazards model, the pretreatment NLR, tumor diameter and pretreatment alpha-fetoprotein (AFP) levels were independent predictors of OS. The CLIP score had superior discriminative abilities compared with other staging systems, and the NLR-PLR score consistently displayed a higher AUROC value than the other inflammation-based prognostic scores. The combination of the NLR-PLR and CLIP scores exhibited a superior prognostic ability for OS compared to the NLR-PLR or CLIP scores alone.ConclusionsThe NLR-PLR score is a more powerful predictive system than the other inflammation-based scores for patients with HCC who were treated with TACE and H101. The predictive ability may be improved by utilizing a combination of the NLR-PLR and CLIP scores.

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Prognostic value of combined preoperative fibrinogen and neutrophil-lymphocyte ratio in patients with hepatocellular carcinoma after liver transplantation

Cited by 23 publications

References 37 publications

Innovative Blood Tests for Hepatocellular Carcinoma: Liquid Biopsy and Evaluation of Systemic Inflammatory Reaction

Innovative Blood Tests for Hepatocellular Carcinoma: Liquid Biopsy and Evaluation of Systemic Inflammatory Reaction

Preoperative neutrophil-lymphocyte ratio predicts the risk of microvascular invasion in hepatocellular carcinoma: A meta-analysis

Inflammation scores predict the survival of patients with hepatocellular carcinoma who were treated with transarterial chemoembolization and recombinant human type-5 adenovirus H101

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