Prognostic Value of Circulating Adipokine Levels and Expressions of Adipokines in the Myocardium of Patients With Chronic Heart Failure

Yin, Wei Hsian; Wei, Jeng; Huang, Wen; Chen, Jaw Wen; Young, Mason Shing; Lin, Shing Jong

doi:10.1253/circj.cj-11-1549

Cited by 20 publications

(19 citation statements)

References 40 publications

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“…Increased adiponectin was associated with higher mortality in ischaemic but not in non-ischaemic HF Japanese patients [21]. In our observation higher concentration of adiponectin was related to urgent heart transplantation and to combined endpoint in NIDCM patients, which is partly consistent with the results obtained by Yin et al [22]. However, we demonstrated that higher concentration of adiponectin was not a predictive marker for death, and in this aspect our results are concordant with the findings of Tamura et al [21].…”

Section: Prace Oryginalnesupporting

confidence: 92%

Wpływ BMI, stężenia leptyny i adiponektyny na rokowanie u pacjentów z niedokrwienną kardiomiopatią rozstrzeniową

Wojciechowska

Jacheć

Romuk

et al. 2017

Endokrynologia Polska

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Introduction:The recent studies demonstrated that obese heart failure patients have better prognosis -"obesity paradox". The aim of the study was to evaluate the relationship between body mass index (BMI), leptin and adiponectin concentrations and prognosis in patients with heart failure due to non ischeamic dilated cardiomyopathy (NIDCM). Material and methods: 128 patients with NIDCM were included and followed-up for three years. Leptin and adiponectin were measured at baseline using commercially available ELISA tests. Clinical data, routine laboratory parameters, NT-proBNP were assessed as risk factors for reaching the study endpoints: urgent heart transplantation (B), death (C), or combined endpoint death or urgent heart transplantation (D). Results: Patient with adverse outcome had lower BMI and higher NT-proBNP concentration. Leptin was significantly elevated in group C and adiponectin was higher in groups B and D than in survived patients. Patients with leptin concentration below median or with adiponectin concentration above median were more often transplanted in three years follow-up (p = 0.029, p = 0.022, respectively). The cumulative probability of death was greater in patients with concentration of leptin above median (p = 0.024). In the multivariable Cox proportional hazards analyses, increasing leptin and lower BMI were predictors of death. Adiponectin was associated with higher risk of heart transplantation. Both an inverse association of BMI and positive association of leptin and adiponectin with combined endpoint were discovered. Further adjustment to established risk factors abolished association between combined endpoint and BMI, and modestly attenuate with adiponectin and leptin concentration. Conclusion: Evaluation of adiponectin and leptin concentrations was more useful than BMI in prediction of unfavourable outcome in patients with NIDCM. (Endokrynol Pol 2017; 68 (1): 26-34)

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Section: Prace Oryginalnesupporting

confidence: 92%

Wpływ BMI, stężenia leptyny i adiponektyny na rokowanie u pacjentów z niedokrwienną kardiomiopatią rozstrzeniową

Wojciechowska

Jacheć

Romuk

et al. 2017

Endokrynologia Polska

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“…CC is a well-known predictor of mortality in patients with CHF and supposed to be associated with advanced-stage heart failure [1,17]. In our study, we observed significantly higher adiponectin levels in CHF patients in comparison with healthy controls, as well as significantly higher adiponectin levels in CHF patients with cachexia compared to CHF patients without cachexia.…”

Section: Discussionsupporting

confidence: 68%

Serum Adiponectin, Anemia and Left Ventricular Dimensions in Patients with Cardiac Cachexia

Bozçalı¹,

Polat²,

Akbulut³

et al. 2013

Cardiology

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Objectives: Our study aims to determine the role of serum adiponectin in chronic heart failure (CHF) and cardiac cachexia (CC). Methods: Ninety consecutive patients were included in the study. Patients were divided into three groups: 30 CHF patients with CC, 30 CHF patients without CC, and 30 healthy individuals. Adiponectin levels were measured through human ELISA kits. Results: Levels of serum adiponectin were significantly higher in the CHF patients with cachexia in comparison with the other groups (CHF with CC: 58.4 ± 15.5 ng/ml vs. CHF without CC: 24 ± 6.7 ng/ml and controls: 7.7 ± 3.4 ng/ml; p = 0.001). Serum adiponectin was negatively correlated with BMI, high-sensitivity C-reactive protein, and hemoglobin (r = -0.37, p = 0.02; r = -0.29, p = 0.02; r = -0.18, p = 0.03, respectively) in the CHF patients with cachexia. Additionally, serum adiponectin levels were positively correlated with B-type natriuretic protein levels, left ventricle end-diastolic and end-systolic diameters (r = 0.36, p = 0.02; r = 0.46, p = 0.01; r = 0.49, p = 0.006, respectively) in the CHF patients with cachexia. Conclusion: Our findings suggest that adiponectin may play a critical role in the pathogenesis of cardiac remodeling and anemia in CC.

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“…18 In addition, low adiponectin and decreased catecholamine response associated with increased BMI are linked to improved HF survival. 19, 20 In addition, NTproBNP is significantly increased in HF and also predicts mortality in patients with advanced HF. Overweight and obesity, however, were commonly associated with lower circulating NT-proBNP, 21 which was also observed in the present study and may further serve as a possible protective mechanism in patients treated by CRT with elevated BMI.…”

Section: Bmi and Long-term Outcomementioning

confidence: 99%

Association of Body Mass Index With Cardiac Reverse Remodeling and Long-Term Outcome in Advanced Heart Failure Patients With Cardiac Resynchronization Therapy

Cai

Hua

Ding

et al. 2014

Circ J

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Prognostic Value of Circulating Adipokine Levels and Expressions of Adipokines in the Myocardium of Patients With Chronic Heart Failure

Cited by 20 publications

References 40 publications

Wpływ BMI, stężenia leptyny i adiponektyny na rokowanie u pacjentów z niedokrwienną kardiomiopatią rozstrzeniową

Wpływ BMI, stężenia leptyny i adiponektyny na rokowanie u pacjentów z niedokrwienną kardiomiopatią rozstrzeniową

Serum Adiponectin, Anemia and Left Ventricular Dimensions in Patients with Cardiac Cachexia

Association of Body Mass Index With Cardiac Reverse Remodeling and Long-Term Outcome in Advanced Heart Failure Patients With Cardiac Resynchronization Therapy

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