2008
DOI: 10.7326/0003-4819-149-11-200812020-00248
|View full text |Cite
|
Sign up to set email alerts
|

Abstract: Positive ELISpot results predict subsequent development of active tuberculosis in recent tuberculosis contacts. Although tuberculosis contacts with positive ELISpot results have an incidence rate of tuberculosis similar to that of contacts with positive tuberculin skin test results, ELISpot testing could allow more focused targeting of preventive therapy to fewer contacts.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1
1

Citation Types

4
140
0
4

Year Published

2009
2009
2016
2016

Publication Types

Select...
9

Relationship

0
9

Authors

Journals

citations
Cited by 140 publications
(148 citation statements)
references
References 39 publications
4
140
0
4
Order By: Relevance
“…According to a recent prospective cohort study from Turkey, the risk of progression to tuberculosis in household contact children with a positive ELISPOT result was 3-4-fold increased compared with children with negative ELISPOT results [144], which was, however, not significantly superior to the tuberculin skin test in predicting the progression to tuberculosis in these children. Guidelines in the UK [102,119] and Germany [118,145] recommend IGRAs as confirmatory tests following a positive tuberculin skin test in adults and children, whereas current French [146] and Canadian [147] guidelines refrain from recommending their use in children.…”
Section: Sectionmentioning
confidence: 99%
“…According to a recent prospective cohort study from Turkey, the risk of progression to tuberculosis in household contact children with a positive ELISPOT result was 3-4-fold increased compared with children with negative ELISPOT results [144], which was, however, not significantly superior to the tuberculin skin test in predicting the progression to tuberculosis in these children. Guidelines in the UK [102,119] and Germany [118,145] recommend IGRAs as confirmatory tests following a positive tuberculin skin test in adults and children, whereas current French [146] and Canadian [147] guidelines refrain from recommending their use in children.…”
Section: Sectionmentioning
confidence: 99%
“…92 Development of TB was also assessed in child and adolescent contacts. Bakir et al 93 studied 908 children with recent household exposure to TB, most of whom received preventive therapy. During a follow-up of 1.3 years, children with positive T-SPOT.TB had a 3-to 4-fold higher risk of developing active TB than those with negative T-SPOT.TB.…”
Section: Interferon-γ-based Assays For Predicting Subsequent Active Tmentioning
confidence: 99%
“…Thus, none of the existing tests can accurately identify the subgroup that is at risk of progression to disease. This is borne out by the sobering fact that IGRAs have been shown to have only a modest predictive ability, and several studies show similar (and rather low) rates of progression among individuals with positive TST and IGRA results [2][3][4][5][6] . For example, the incidence rate of active disease in TB contacts with positive IGRA results was 9.2 per 1000 person-years (PY) in the Gambia 2 , 20.5 per 1000 PY in Turkey 4 and 7.7 per 1000 PY in Colombia 6 .…”
mentioning
confidence: 99%