Prognostic Value and Echocardiographic Determinants of Plasma Myeloperoxidase Levels in Chronic Heart Failure

Tang, W.H. Wilson; Tong, Wilson; Troughton, Richard W.; Martin, Maureen G.; Shrestha, Kevin; Borowski, Allen G.; Jasper, Sue; Hazen, Stanley L.; Klein, Allan L.

doi:10.1016/j.jacc.2007.02.053

Cited by 170 publications

(147 citation statements)

References 33 publications

Supporting

Mentioning

133

Contrasting

Unclassified

Order By: Relevance

“…These results may in part support the findings that the expression and systemic levels of MPO are not elevated in stable CAD [27,28]. They are, however, in contrast to the suggestion to determine the systemic MPO levels as an emerging powerful and rapidly detectable marker for unstable CAD [24][25][26]. Our findings further support the concept that the robust release of MPO from activated PMN would reveal a state of acute inflammation in the coronary circulation preceding myocardial injury, but this may not be applied to other arterial disease.…”

Section: Discussionsupporting

confidence: 74%

See 1 more Smart Citation

Elevated MMP‐8 and Decreased Myeloperoxidase Concentrations Associate Significantly with the Risk for Peripheral Atherosclerosis Disease and Abdominal Aortic Aneurysm¹

et al. 2010

View full text Add to dashboard Cite

Matrix metalloproteinases are responsible for degradation and remodelling of extracellular matrix and exert important roles in initiation and progression of inflammatory diseases. We aimed to examine the role of Matrix metalloproteinases (MMPs) and their regulators in degenerative arterial diseases. Serum samples were collected from patients with arterial disease (n = 126), who underwent surgery because of symptomatic aorto‐occlusive disease (AOD, n = 18), carotid artery stenosis (n = 67) or abdominal arotic aneurysm (n = 41). Serum MMP‐1, MMP‐8, MMP‐13, TIMP‐1, myeloperoxidase (MPO) and neutrophil elastase (HNE) concentrations were determined by ELISA, and the molar ratio of MMP‐8 and TIMP‐1 was calculated. To get reference values, the determinations were done on samples of healthy blood donors (n = 100). In univariate analyses, the patients had higher MMP‐8 (P < 0.001), TIMP‐1 (P = 0.045), and MMP‐8/TIMP‐1 (P < 0.001), and lower MPO (P < 0.001) when compared with the blood donors. All three subgroups had higher MMP‐8 (P < 0.001) and MMP‐8/TIMP‐1 (P < 0.001), and lower MPO (P < 0.01, except AOD) levels when compared with the references. In multiple logistic regression analyses, the male gender (P < 0.01), age (P < 0.001), elevated MMP‐8 (P < 0.001) and decreased MPO (P < 0.001) concentrations associated significantly with the risk for arterial disease, and provided an area under curve (AUC) of 0.97 in the Receiver operating characteristics analyses. In multiple linear regression analyses, HNE correlated with both MMP‐8 (P < 0.001) and MPO (P = 0.008) concentrations. Combination of high MMP‐8 and low MPO level in serum eventually reflecting selectively modified neutrophil degranulation may indicate increased risk for arterial disease.

show abstract

Section: Discussionsupporting

confidence: 74%

“…MPO has emerged as a powerful predictor for adverse outcome in patients with acute CAD [24][25][26]. Interestingly, Kubala et al [27] showed that the plasma levels of MPO were not elevated in patients with stable CAD, supporting the previous findings that the activation and recruitment of PMN was reduced in stable CAD [28].…”

Section: Discussionmentioning

confidence: 79%

Elevated MMP‐8 and Decreased Myeloperoxidase Concentrations Associate Significantly with the Risk for Peripheral Atherosclerosis Disease and Abdominal Aortic Aneurysm¹

et al. 2010

View full text Add to dashboard Cite

show abstract

“…MPO levels have been shown in multiple studies to track with incident risks of CVD events in subjects (53,(55)(56)(57). The present studies may help to explain prior reports of pro-inflammatory HDL in the acute phase setting, as well as during chronic inflammation such as in CVD.…”

Section: Discussionsupporting

confidence: 61%

Modification of High Density Lipoprotein by Myeloperoxidase Generates a Pro-inflammatory Particle

Undurti

Huang

Lupica

et al. 2009

Journal of Biological Chemistry

Self Cite

237

178

View full text Add to dashboard Cite

High density lipoprotein (HDL) is the major atheroprotective particle in plasma. Recent studies demonstrate that myeloperoxidase (MPO) binds to HDL in vivo, selectively targeting apolipoprotein A1 (apoA1) of HDL for oxidative modification and concurrent loss in cholesterol efflux and lecithin cholesterol acyl transferase activating activities, generating a "dysfunctional HDL" particle. We now show that (patho)physiologically relevant levels of MPO-catalyzed oxidation result in loss of noncholesterol efflux activities of HDL including anti-apoptotic and anti-inflammatory functions. One mechanism responsible is shown to involve the loss of modified HDL binding to the HDL receptor, scavenger receptor B1, and concurrent acquisition of saturable and specific binding to a novel unknown receptor independent of scavenger receptors CD36 and SR-A1. HDL modification by MPO is further shown to confer pro-inflammatory gain of function activities as monitored by NF-B activation and surface vascular cell adhesion molecule levels on aortic endothelial cells exposed to MPO-oxidized HDL. The loss of non-cholesterol efflux activities and the gain of pro-inflammatory functions requires modification of the entire particle and can be recapitulated by oxidation of reconstituted HDL particles comprised of apoA1 and nonoxidizable phosphatidylcholine species. Multiple site-directed mutagenesis studies of apoA1 suggest that the pro-inflammatory activity of MPO-modified HDL does not involve methionine, tyrosine, or tryptophan, oxidant-sensitive residues previously mapped as sites of apoA1 oxidation within human atheroma. Thus, MPO-catalyzed oxidation of HDL results not only in the loss of classic atheroprotective reverse cholesterol transport activities of the lipoprotein but also both the loss of non-cholesterol efflux related activities and the gain of pro-inflammatory functions. High density lipoprotein (HDL)3 is a complex mixture of cholesterol carrying lipoprotein particles built upon a predominantly apolipoprotein A1 (apoA1) backbone. HDL is currently thought to function primarily in mediating reverse cholesterol transport (RCT), the net transport of cholesterol from peripheral tissues to the liver for ultimate elimination into the intestinal lumen as biliary cholesterol for excretion in feces (1). RCT involves multiple biochemical processes, including both lipid poor apoA1 and HDL serving as acceptors of cholesterol efflux from peripheral cholesterol loaded cells, maturation of HDL from a nascent relatively cholesterol poor particle into a cholesterol-laden spherical form through interaction with lecithin cholesterol acyl transferase (LCAT), and delivery of cholesterol to liver and steroidogenic tissues through the HDL receptor, scavenger receptor B1 (SR-B1) (2).Although the RCT related functions of apoA1 and HDL are thought to primarily account for both the atheroprotective activity and the strong inverse association of HDL cholesterol and apoA1 levels and cardiovascular risks, other non-cholesterol efflux-related activities have a...

show abstract

“…This enzyme converts the low density lipoprotein into the atherogenic form, many reactive oxidants and free radicals occur and contribute to endothelial dysfunction by decreasing the nitric oxide level. MPO and MPO oxidant products can be a biomarker for the complications occurring during coronary heart disease and chronic heart failure (Tang et al, 2007;Morrow et al, 2008). Ronald et al (2009) determined that MPO activity is high in biochemical experiments comparing atherosclerotic plaques to normal arterial walls.…”

Section: Discussionmentioning

confidence: 99%

The importance of myeloperoxidase enzyme activity in the pathogenesis of Crimean–Congo haemorrhagic fever

Güven

Aydın

Yıldız

et al. 2013

Journal of Medical Microbiology

View full text Add to dashboard Cite

Prognostic Value and Echocardiographic Determinants of Plasma Myeloperoxidase Levels in Chronic Heart Failure

Abstract: In chronic systolic HF, elevated plasma MPO levels are associated with an increased likelihood of more advanced HF. Moreover, elevated plasma MPO levels within a HF subject seem to be predictive of increased adverse clinical outcomes.

Cited by 170 publications

References 33 publications

Elevated MMP‐8 and Decreased Myeloperoxidase Concentrations Associate Significantly with the Risk for Peripheral Atherosclerosis Disease and Abdominal Aortic Aneurysm¹

Elevated MMP‐8 and Decreased Myeloperoxidase Concentrations Associate Significantly with the Risk for Peripheral Atherosclerosis Disease and Abdominal Aortic Aneurysm¹

Modification of High Density Lipoprotein by Myeloperoxidase Generates a Pro-inflammatory Particle

The importance of myeloperoxidase enzyme activity in the pathogenesis of Crimean–Congo haemorrhagic fever

Contact Info

Product

Resources

About

Prognostic Value and Echocardiographic Determinants of Plasma Myeloperoxidase Levels in Chronic Heart Failure

Abstract: In chronic systolic HF, elevated plasma MPO levels are associated with an increased likelihood of more advanced HF. Moreover, elevated plasma MPO levels within a HF subject seem to be predictive of increased adverse clinical outcomes.

Cited by 170 publications

References 33 publications

Elevated MMP‐8 and Decreased Myeloperoxidase Concentrations Associate Significantly with the Risk for Peripheral Atherosclerosis Disease and Abdominal Aortic Aneurysm1

Elevated MMP‐8 and Decreased Myeloperoxidase Concentrations Associate Significantly with the Risk for Peripheral Atherosclerosis Disease and Abdominal Aortic Aneurysm1

Modification of High Density Lipoprotein by Myeloperoxidase Generates a Pro-inflammatory Particle

The importance of myeloperoxidase enzyme activity in the pathogenesis of Crimean–Congo haemorrhagic fever

Contact Info

Product

Resources

About

Elevated MMP‐8 and Decreased Myeloperoxidase Concentrations Associate Significantly with the Risk for Peripheral Atherosclerosis Disease and Abdominal Aortic Aneurysm¹

Elevated MMP‐8 and Decreased Myeloperoxidase Concentrations Associate Significantly with the Risk for Peripheral Atherosclerosis Disease and Abdominal Aortic Aneurysm¹