Prognostic significance of the neutrophil-to-lymphocyte ratio in peripheral T-cell lymphoma: a meta-analysis

Abstract

The neutrophil-to-lymphocyte ratio (NLR) as an inflammatory marker may represent changes between inflammation and host immunity that affect the prognosis of peripheral T-cell lymphoma (PTCL). To comprehensively evaluate the NLR in PTCL, we performed a meta-analysis to investigate the relationship between the NLR and overall survival (OS) and progression-free survival (PFS). PubMed, Embase, Cochrane library, and China National Knowledge Infrastructure (CNKI) were searched for all relevant studies. Hazard ratios (HRs) and 95% confidence intervals (CIs) were obtained from each study. Heterogeneity among the included studies was checked to determine whether fixed or random effects model was used. In total, 8 studies with 921 patients were included for the meta-analysis. High NLR significantly correlated with worse OS (HR = 2.20, 95% CI 1.71–2.83, P < 0.05) regardless of region (Asian or non-Asian), sample size (< 60 or ≥ 60), median age (< 60 or ≥ 60), disease type, or cut-off value (NLR < 3.9 or NLR ≥ 3.9). In terms of PFS, the NLR had no prognostic impact for patients with PTCL (HR = 1.12, 95% CI 0.57–2.20, P = 0.742). Our findings suggest that PTCL patients with high NLR are more likely to have worse OS compared to those with low NLR. Therefore, the NLR can serve as a prognostic marker in PTCL.

Systemic inflammation and its relationship with pruritus in early‐stage mycosis fungoides

“…In a meta‐analysis on peripheral T‐cell lymphomas (PTCL), high NLR correlated with worse overall survival in PTCL patients (921 patients, 8 studies), highlighting NLR's prognostic potential in PTCL 11 . Cosimo Di Raimondo and colleagues 12 observed in 302 MF patients that advanced‐stage MF correlated with higher NLR (median 2.64), while early‐stage patients had lower NLR (median 1.88), suggesting NLR's role in identifying advanced stages with 67.6% sensitivity and 60.4% specificity.…”

Targeting the cGAS‐STING Pathway Inhibits Peripheral T‐cell Lymphoma Progression and Enhances the Chemotherapeutic Efficacy

“…[ 35 , 36 ] A high neutrophil‐to‐lymphocyte ratio, an inflammatory marker representing changes between inflammation and host immunity, correlates with worse overall survival in patients with PTCL. [ 37 ] Moreover, autoregulatory cytokines, including IFN‐γ (secreted by CD4+ malignant T cells) and IL‐6 (secreted by activated granulocytes), could mediate granulocyte‐lymphoma interaction, thereby triggering inflammatory symptoms, enhancing lymphoma infiltration and affecting the survival of patients with PTCL. [ 38 ] Similarly, increased serum IL‐10 levels predict poor survival and early recurrence in patients with PTCL.…”

T-cell lymphoma infiltrating the uterus and ovaries of a Golden Retriever: a case report

“…Therefore, many pro-inflammatory cytokines are produced in this process along with malignant lymphocytes, which induce systemic inflammation when pro-inflammatory cytokines overwhelm anti-inflammatory cytokines. Indeed, an elevated pre-treatment neutrophil-to-lymphocyte ratio, a marker for SIRS, has prognostic significance in humans with ovarian cancer and T-cell lymphoma [ 37 , 38 ]. Therefore, we assumed that the cause of the deterioration might have been due to further progression of SIRS in the present case after the surgery despite having stabilized the dog’s vital signs prior to surgical resection of ovarian and uterine lymphoma.…”