Prognostic significance of standardized uptake value and metabolic tumour volume on 18F-FDG PET/CT in oropharyngeal squamous cell carcinoma

Kim, Ji Won; Oh, Jungsu S.; Roh, Jong–Lyel; Kim, Jae Seung; Choi, Seung‐Ho; Nam, Soon Yuhl; Kim, Sang Yoon

doi:10.1007/s00259-015-3051-4

Cited by 34 publications

(49 citation statements)

References 34 publications

(63 reference statements)

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“…The cut-off values for MTV predicting worse prognosis ranged between 7.7 and 45 cm3 and those of TLG ranged from 55 to 330 g 9 .. In a retrospective study including 221 patients, Kim et al 51 assessed the prognostic values of pre-treatment FDG-PET markers, as SUV max , MTV, and TLG in a uniform sample of only OPSCC patients, although the HPV status was obtained for a limited sample of patients. Using univariate Cox proportional hazards regression analysis, investigators concluded that age > 60 years, advanced tumour stage, primary tumor SUV max > 7.55, SUV peak > 6.80, MTV > 11.06 ml, and TLG > 78.56 g. were significantly associated with decreased OS and disease-free survival.…”

Section: Discussionmentioning

confidence: 99%

Value of Intratumoral Metabolic Heterogeneity and Quantitative 18F-FDG PET/CT Parameters to Predict Prognosis in Patients With HPV-Positive Primary Oropharyngeal Squamous Cell Carcinoma

Mena

Taghipour

Sheikhbahaei

et al. 2017

Clinical Nuclear Medicine

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Objective To evaluate the impact of intra-tumoral metabolic heterogeneity and quantitative FDG-PET/CT imaging parameters for predicting patient outcomes in primary oropharyngeal squamous cell cancer (OPSCC). METHOD AND MATERIALS We retrospective investigated 105 patients with HPV-positive OPSCC. Maximum standardized uptake value (SUVmax,), and metabolic tumor volume (MTV)were measured for the primary tumors and when available for the metastatic sites. Primary tumor intra-tumoral metabolic heterogeneity was calculated as the area under a cumulative SUV-volume Histograms curve (AUC-CSH). The median follow-up time was 35.4 months (range 3-92 months). Outcome endpoint was event free survival (EFS). Kaplan–Meier survival plots and Cox regression analyses were performed. RESULTS Of the 105 patients included, 19 patients relapsed and 11 deceased during the study period. AUC-CSH indexes were associated with EFS using PET gradient-based (p=0.034) and 50%-Threshold (p=0.02) segmentation methods, on multivariate analysis. Kaplan–Meier survival analysis using optimum cutoff of 16.7 SUVmax and 12.7 ml total MTV were significant predictors of EFS. Combining SUVmax and AUC-CSH index in three subgroups, patients with higher intra-tumoral heterogeneity and higher SUVmax were associated with worse outcome (log-rank p=0.026). Similarly, patients with higher intra-tumoral heterogeneity tumors and higher MTV had worse prognosis (log-rank, p= 0.022). CONCLUSION Intra-tumoral metabolic heterogeneity using FDG-PET was a prognostic factor for EFS in patients with primary HPV (+) OPSCC. The combined predictive effect of FDG avidity, metabolic tumor burden and intra-tumoral heterogeneity provided prognostic survival information in these patients.

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Section: Discussionmentioning

confidence: 99%

Value of Intratumoral Metabolic Heterogeneity and Quantitative 18F-FDG PET/CT Parameters to Predict Prognosis in Patients With HPV-Positive Primary Oropharyngeal Squamous Cell Carcinoma

Mena

Taghipour

Sheikhbahaei

et al. 2017

Clinical Nuclear Medicine

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“…En accord avec les données de la littérature [28][29][30], nous avons alors observé que le volume métabolique tumoral initial apparaît comme un facteur pronostique, puisqu'il était significativement plus important ( p = 0,0005) dans le groupe de patients ayant récidivé localement, comparativement aux patients en rémission. Cette information pourrait permettre dans un premier temps de sélectionner initialement les patients ayant un MTV élevé, les plus à risques de récidive, qui pourraient bénéficier d'un traitement plus agressif.…”

Section: Discussionunclassified

Identification des sites de récidive sur la TEP/TDM initiale dans les cancers des VADS traités par radiochimiothérapie

et al. 2016

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“…A nuclear medicine physicist (Jungsu S. Oh) generated quantitative 18 F‐FDG activity measurements of tumors with PET data reconstruction and SUV equalization, and subsequently fed the reconstructed 18 F‐FDG PET data into an in‐house PET image quantification software program (AMC NM Toolkit for Image Quantification of Excellence; ANTIQUE) . 18 F‐FDG‐PET activity was determined by calculating SUV using decay‐corrected activity in the tissue divided by the injected dose of 18 F‐FDG per lean body mass of the patient.…”

Section: Methodsmentioning

confidence: 99%

“…18 F‐FDG PET/CT is used to assess the initial stages of disease and treatment responses, and to make posttreatment selections and prognostic predictions . The standardized uptake value (SUV) is a semiquantitative measurement of the tissue glucose metabolic rate, and a high value in a tumor may be associated with poor survival outcome . Moreover, volumetric PET parameters such as metabolic tumor volume (MTV) and total lesion glycolysis (TLG) have been recognized as potentially better predictors of treatment and survival .…”

Section: Introductionmentioning

confidence: 99%

Metabolic tumor volume and total lesion glycolysis predict tumor progression and survival after salvage surgery for recurrent oral cavity squamous cell carcinoma

Choi

Roh

et al. 2019

Head & Neck

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Background This study evaluated the prognostic role of Fluorine 18‐fluorodeoxyglucose positron emission tomography/CT (18F‐FDG PET/CT) parameters quantitatively measured in patients with recurrent oral cavity cancer. Methods Cox proportional hazards regression analyses were used to assess the associations between quantitative 18F‐FDG PET/CT parameters and other clinicopathological factors and progression‐free survival (PFS) and overall survival (OS). Results All of the 18F‐FDG PET parameters (SUVmax, SUVmean, SUVpeak, metabolic tumor volume [MTV], and total lesion glycolysis [TLG]) were significantly associated with poor PFS and OS outcomes after salvage treatment (P < .01). In multivariate analyses, Karnofsky performance score, recurrence site, MTV, and TLG were independent variables predictive of both PFS and OS (P < .05). High MTV (>8.8 mL) or TLG (>29.4 g) values at recurrent lesions were associated with >5‐fold increased risk for tumor progression and mortality after salvage surgery. Conclusions The PET parameters of MTV and TLG measured at recurrent lesions may predict tumor progression and survival after salvage treatment. Condensed Abstract This study examined the role of 18F‐FDG PET/CT at recurrent staging for predicting tumor progression and survival in 71 consecutive patients with recurrent oral cavity squamous cell carcinomas. Of 18F‐FDG parameters, metabolic tumor volume and total lesion glycolysis were independent factors predictive of tumor progression and survival after salvage treatment.

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Prognostic significance of standardized uptake value and metabolic tumour volume on 18F-FDG PET/CT in oropharyngeal squamous cell carcinoma

Cited by 34 publications

References 34 publications

Value of Intratumoral Metabolic Heterogeneity and Quantitative 18F-FDG PET/CT Parameters to Predict Prognosis in Patients With HPV-Positive Primary Oropharyngeal Squamous Cell Carcinoma

Value of Intratumoral Metabolic Heterogeneity and Quantitative 18F-FDG PET/CT Parameters to Predict Prognosis in Patients With HPV-Positive Primary Oropharyngeal Squamous Cell Carcinoma

Identification des sites de récidive sur la TEP/TDM initiale dans les cancers des VADS traités par radiochimiothérapie

Metabolic tumor volume and total lesion glycolysis predict tumor progression and survival after salvage surgery for recurrent oral cavity squamous cell carcinoma

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