2019
DOI: 10.31557/apjcp.2019.20.8.2471
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Abstract: Background and study aim: Cyclin D1 is a key regulatory protein in the cell cycle and is over-expressed in many tumors, including endometrial, thyroid, urothelial, breast, brain gliomas, and esophageal cancers. The main aim of the present study is to examine the expression pattern of cyclin D1 and its correlation with the different clinicopathological features in patients with colorectal camcer (CRC) from the Madinah region of Saudi Arabia. Patients and methods:The archival tumor blocks were analyzed using imm… Show more

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Cited by 16 publications
(7 citation statements)
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References 31 publications
(44 reference statements)
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“…Caspases will be activated before exerting their effects on cell apoptosis ( 30 ). Cyclin D1 is an important checkpoint regulator factor during the transition from the G1 to S phase ( 31 ). The present study found that the mechanism through which CCAT2 induces the inhibition of TC cell apoptosis involved decreased activation of caspase cascades and Bax, and increased activation of Bcl-2.…”
Section: Discussionmentioning
confidence: 99%
“…Caspases will be activated before exerting their effects on cell apoptosis ( 30 ). Cyclin D1 is an important checkpoint regulator factor during the transition from the G1 to S phase ( 31 ). The present study found that the mechanism through which CCAT2 induces the inhibition of TC cell apoptosis involved decreased activation of caspase cascades and Bax, and increased activation of Bcl-2.…”
Section: Discussionmentioning
confidence: 99%
“…Hasil ini juga sesuai dengan data dari WHO yang menyebutkan bahwa insiden karsinoma kolorektal meningkat seiring dengan bertambahnya usia dan jarang terjadi pada usia di bawah 40 tahun, kecuali pada individu dengan predisposisi genetik atau suatu kondisi predisposisi seperti inflammatory bowel disease yang kronis. 20,21,22,23 Lokasi terbanyak adenoma adalah rektosigmoid, hasil ini sesuai dengan banyak penelitian sebelumnya yang menyatakan bahwa lokasi tersering dari adenoma adalah daerah rektosignoid. Sedangkan hasil untuk kelompok adenokarsinoma pada penelitian terbanyak di daerah colon ascenden, hasil ini tidak sesuai dengan penelitian retrospektif oleh peneliti yang dilakukan sebelumnya di instalasi yang sama, yaitu dari 300 kasus adenokarsinoma pada tahun 2016-2018 didapatkan sebanyak 62% adenokarsinoma terletak di daerah rektosigmoid.…”
Section: Pembahasanunclassified
“…Cyclin D1 (CCND1) is crucial for sustaining cell proliferation, and mutations or deficiency of CCND1 may cause cell-cycle arrest and death. 29–31 Of note, CCND1 served as an oncogene to promote the development of various cancers, such as colorectal cancer, 32 breast cancer 33 and OSCC. 34 , 35 Interestingly, researchers noticed that silencing of CCND1 was proved to be an effective strategy to slow down OSCC progression.…”
Section: Introductionmentioning
confidence: 99%