Prognostic Significance of Basic Laboratory Methods in Non-Small-Cell-Lung Cancer

Abstract

Background: In our study, the LDH, albumin, hemoglobin, neutrophile, thrombocyte, lymphocyte counts and prognostic significance of neutrophile-lymphocyte and thrombocyte-lymphocyte ratios in NSCLC derived from these counts obtained during regular examinations of patients were examined. Materials and Methods: Histopathologically diagnosed non-small-cell-lung cancer patients between 2008 and 2010 were included in the study. Before the treatment, full blood count including routine lymphocyte count, blood biochemistry examinations including liver (AST, ALT, total protein, Albumin), LDH and kidney (BUN, Cre) function tests were performed. Results: A total of 156 patients, 76 of whom (48.7%) were female and 80 of whom (51.3%) were male were included. Mean hemoglobin level was determined as 12. Overall survival was found to be significantly dependent on whether patients were anemic or not (p: 0.005). Mean LDH level was determined as 233.4. There was nosurvival difference between patients with and without high LDH (p: 0.532). In patients where NLR showed systemic inflammatory response, overall survival was 10.8 months whereas this duration was 19.6 months in patients where the systemic inflammatory response was negative (p: 0.012). In patients where TLR showed systemic inflammatory response, overall survival was 13.6 months whereas this duration was 21.9 months in patients where the systemic inflammatory response was negative (p: 0.04). Conclusions: Molecular methods have been changing rapidly in today's world and they manage the treatment besides defining the prognosis of patients. However, easily accessible and cheap laboratory parameters should be considered in the prognosis of patients besides these new methods.

Elevated Serum Neutrophil to Lymphocyte and Platelet to Lymphocyte Ratios Could be Useful in Lung Cancer Diagnosis

“…al and Vildan Kaya et. al reported that pretreatment NLR measurements can predict patient prognosis in NSCLC patients (Kaya et al, 2013, Unal et al, 2013.…”

Albumin-globulin Ratio for Prediction of Long-term Mortality in Lung Adenocarcinoma Patients

“…(Gabay et al, 1999;Mantovani et al, 2008;Yildirim et al, 2013). In several studies, high inflammatory parameters (CRP, alpha and gamma globulins, neutrophil lymphocyte ratio (NLR), complement C3-C4) were found and associated with reduced overall survival in patients with different cancers including lung cancers (Shimada et al, 2003;Canna et al, 2005;Kaya et al, 2013;Zheng et al, 2013;Dai et al, 2014;Soliman et al, 2014). Increasing synthesis of acute phase proteins and interleukins and tumor necrosis-related hypoxia may be the mechanisms underlying this increased inflammation (McMillan et al, 2009).…”

Pretreatment Neutrophil/Lymphocyte Ratio as a Prognostic Aid in Colorectal Cancer

“…After that, emerging evidences from several studies have pointed out that NLR has a prognostic value in patients with pancreatic (Aliustaoglu et al, 2010), breast (Azab et al, 2012), lung (Kaya et al, 2013;Unal et al, 2013) and gastric (Jung et al, 2011) cancers. Recent literature has relatively fewer papers that focused on the significance of the pre-treatment NLR in CRC.…”