Prognostic role of tumor volume for radiotherapy outcome in patient with T2 laryngeal cancer

Rutkowski, T.; Wygoda, A.; Składowski, Krzysztof; Hejduk, B.; Rutkowski, Roman; Kołosza, Zofia; Maciejewski, B.

doi:10.1007/s00066-013-0411-5

Cited by 19 publications

(26 citation statements)

References 32 publications

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“…Patients with SD ≤ 5 months had reduced LC ratio and over 2 times higher risk of local failure. This observation is in concordance with our pervious report [6] but had not been described before. Beside the primary tumor localization in the supraglottic area, also rapid tumor proliferation and fast progression of TV may be the reason of early symptoms.…”

Section: Discussionsupporting

confidence: 94%

“…Hereby we also found that patients with lower Hb concentration presented significantly poorer OS rate. Beside this, the negative relationship between Hb and TV was found what is in concordance with our previous observation for both, glottic and supraglottic tumors [6]. Negative correlation between Hb concentration and TV was also found by Stadler [22].…”

Section: Discussionsupporting

confidence: 92%

“…Hemoglobin concentration appeared to be an independent prognostic factor for patients with laryngeal cancer treated with RT [6, 24]. Hereby we also found that patients with lower Hb concentration presented significantly poorer OS rate.…”

Section: Discussionsupporting

confidence: 67%

“…Besides a significant influence of TV on treatment outcome in that group of patients, TV was found to be strongly related to some other prognostic factors. Moreover, volumes of supraglottic tumors appeared to be higher than glottic ones [6]. It suggested that relationship between TV and other factors may by even stronger expressed for supraglottic tumors and needs to be analyzed independently.…”

Section: Introductionmentioning

confidence: 99%

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The effect of tumor volume on radiotherapy outcome and correlation with other prognostic factors in patients with T2 supraglottic cancer

Rutkowski¹,

Maciejewski²,

Kołosza³

et al. 2014

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The retrospective chart review of 110 patients with T2 supraglottic cancer who underwent radiotherapy was performed to correlate tumor volume with other prognostic factors and to analyze its impact on treatment results. Patients with involved nodes, poor histopathological tumor differentiation, or hemoglobin concentration ≤ 14.3 g/dl had significantly larger tumors. Patients with large tumors had significantly lower 5-year local control rate, overall survival rate and presented significantly higher risk of nodal involvement and the ratio of poor histopathological differentiation of the tumor. Tumor volume significantly impacts radiotherapy outcome and should be considered to optimize treatment strategy for patients with T2 supraglottic cancer.

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Section: Discussionsupporting

confidence: 94%

Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 67%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The effect of tumor volume on radiotherapy outcome and correlation with other prognostic factors in patients with T2 supraglottic cancer

Rutkowski¹,

Maciejewski²,

Kołosza³

et al. 2014

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“…Several authors [2,25,27,28] have discussed the role of incorporating tumor stage, HPV/p16 status, and smoking habits in oropharyngeal cancer patients in order to subdivide patients into different risk groups. Inflammatory scoring systems may have the potential to play a similar important role if analyzed consequently in well-characterized treatment groups.…”

Section: Resultsmentioning

confidence: 99%

Primary radiotherapy or postoperative radiotherapy in patients with head and neck cancer

et al. 2015

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Single‐cycle induction chemotherapy followed by chemoradiotherapy or surgery in patients with head and neck cancer: What are the best predictors of remission and prognosis?

Semrau

Haderlein

Schmidt

et al. 2014

Cancer

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BACKGROUND: There is controversy over the concept of function and organ preservation by chemotherapy/chemoradiation instead of surgery in locally advanced cancer of the larynx or pharynx. Tumor response to induction chemotherapy (ICT) can help in choosing between conservative and surgical treatment. This study compared 3 methods of assessing response to ICT: endoscopy, computed tomography, and 18 F-FDG-PET/CT. METHODS: Primary response to 1 cycle of ICT with docetaxel plus platinum was assessed by the aforementioned methods in 62 laryngopharyngeal cancer patients. Endoscopic response was the deciding factor for selecting further treatment: surgery for endoscopic nonresponders (<30% tumor response) versus chemoradiotherapy for endoscopic responders. RESULTS: ICT achieved endoscopic response in 48 of 62 patients (77%). Individual relative residual tumor activity of standardized uptake value (resSUV max ) in 18 F-FDG-PET/CT was a median 0.38 of baseline (0.09-1.71), whereas residual tumor extent in CT (resCT) was 0.75 of baseline (0.32-1.20). Endoscopic responders and nonresponders differed significantly in SUV max after ICT (postSUV max , 6.0 vs 14.5; P <.001), resSUV max (0.34 vs 0.81, P <.001), and resCT (0.71 vs 0.87, P 5.004), but not in maximum tumor diameter after ICT (14 vs 20 mm, P 5.11). resSUV max <0.8 and absolute postSUV max <10 provided the best discriminatory power for long-term success criteria (tumor-free survival, overall survival). CONCLUSIONS: Metabolic tumor response showed very good correlation with clinical tumor response to ICT. The value of metabolic response detected by 18

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Prognostic role of tumor volume for radiotherapy outcome in patient with T2 laryngeal cancer

Cited by 19 publications

References 32 publications

The effect of tumor volume on radiotherapy outcome and correlation with other prognostic factors in patients with T2 supraglottic cancer

The effect of tumor volume on radiotherapy outcome and correlation with other prognostic factors in patients with T2 supraglottic cancer

Primary radiotherapy or postoperative radiotherapy in patients with head and neck cancer

Single‐cycle induction chemotherapy followed by chemoradiotherapy or surgery in patients with head and neck cancer: What are the best predictors of remission and prognosis?

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