Prognostic role of pretreatment 18F-FDG PET/CT in primary brain lymphoma

Introduction: In the present study, we aimed to investigate the prognostic value of metabolic parameters, including maximum standardized uptake value (SUV max ), total metabolic tumour volume (tMTV) and total lesion glycolysis (TLG), measured at baseline 18 F-FDG PET/CT in paediatric lymphoma. Methods: From March 2013 to April 2019, 47 patients with paediatric lymphoma, including 38 males and nine females with an average age of 14.87 years, who underwent 18 F-FDG PET/CT scan prior to treatment were retrospectively included in this study. SUV max , MTV and TLG were recorded. Survival curves were established according to the Kaplan-Meier curves and log-rank test. Mann-Whitney U-test was used to assess differences in metabolic parameters between different clinical outcomes. Results: The median follow-up time was 36 months (range of 3-74 months). The 2-year progression-free survival (PFS) of the low TLG and high TLG groups was 95.24% (20/21) and 57.69% (15/26), respectively (P = 0.004). TLG and tMTV were significantly higher in progression-free patients compared with the progression group. Univariate analysis showed that B symptoms (P = 0.014), effusion (P = 0.010), tMTV (P = 0.008) and TLG (P = 0.004) were the predictive factors for PFS. The tMTV (P = 0.005), TLG (P = 0.005) and effusion (P = 0.003) were associated with OS. Multivariate analysis revealed that TLG was the only independent prognostic factor for PFS (HR = 11.133, 95% CI = 1.435-86.405, P = 0.021). Conclusions: Collectively, TLG of baseline 18 F-FDG PET/CT was an independent prognostic factor for PFS in patients with paediatric lymphoma.

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“…According to recently published data, it remains controversial whether MTV and TLG can be used as prognosticators . Sharma et al .…”

Section: Discussionmentioning

confidence: 99%

Prognostic value of baseline ¹⁸F‐FDG PET/CT metabolic parameters in paediatric lymphoma

et al. 2019

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“…This result also showed that, compared with SUVmax, MTV and TLG of the primary tumor can reflect the metabolic burden of tumor lesions more accurately. Previous studies showed that MTV and TLG could represent a combination of tumor volume and metabolism, including both morphological and metabolic features, and may be considered an expression of tumor aggressiveness in addition to tumor size [34]. Thus, 18F-FDG PET/CT, as a very suitable functional imaging method, can represent the tumor burden [35].…”

Section: Discussionmentioning

confidence: 99%

Value of pretreatment 18F-FDG PET/CT in prognosis and the reflection of tumor burden: a study in pediatric patients with newly diagnosed neuroblastoma

Man¹,

Yan²,

Li³

et al. 2021

Int. J. Med. Sci.

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Fluorine-18 fluorodeoxyglucose (18F-FDG) PET/CT has been commonly used in pediatric patients with newly diagnosed neuroblastoma (NB) for diagnosis. We retrospectively reviewed 40 pediatric patients with newly diagnosed NB who underwent 18F-FDG PET/CT. Clinicopathological factors and metabolic parameters including maximum standardized uptake value (SUVmax), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) on PET/CT were evaluated as predictive factors for progression-free survival (PFS) and overall survival (OS) by univariate and multivariate analysis. Spearman rank correlation analyses were used to estimate the correlations between clinical factors and PET findings. The mean follow-up after 18F-FDG-PET/CT was 32.9 months. During the follow-up period 15 (37.5%) patients experienced progression, and 9 (22.5%) died. MTV (P=0.001) and TLG (p=0.004) remained significant predictive factors for tumor progression, along with lactate dehydrogenase (LDH), neuron-specific enolase (NSE) and bone metastasis. Univariate analysis showed that bone metastasis, LDH (>1064 IU/L), NSE (>364.4 ug/L), MTV (>191 cm3) and TLG (>341.41 g) correlated with PFS, and LDH (>1064 IU/L), NSE (>364.4 ug/L) and MTV (>191 cm 3) correlated with OS (p<0.05). In multivariate analysis, MTV and bone metastasis were independent prognostic factors for PFS (p=0.001 and 0.023, respectively), and MTV remained the only independent prognostic factor for OS (p= 0.004). We also found that there were correlations between semiquantitative PET/CT parameters and clinical features in NB. Our results suggested that 18F-FDG PET/CT was a useful tool to predictive progression and to reflect tumor burden for patients with NB.

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“…MTV and TLG represent a combination of metabolic parameters and morphological findings because they include for definition both radiological and metabolic features can be considered tumor aggressiveness expression. In other malignancies, especially lymphoma, potential prognostic role of metabolic volumes is already demonstrated 34‐37 . The clinical application of MTV and TLG in practice could probably be too early, also due to the lack of a standardized methodology for their measurement; several methods of measurements are suggested in literature with a wide range of cutoff values.…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, there are no shared technical references about the measurements of these parameters and specific cutoff defined for GIST. We used an isocontour threshold method based on 41% of the SUVmax as suggested by EANM 26 and already tested in other papers 34‐37 …”

Section: Discussionmentioning

confidence: 99%

Metabolic behavior and prognostic role of pretreatment 18F‐FDG PET/CT in gist

Albano

Bosio

Tomasini

et al. 2020

Asia-Pac J Clncl Oncology

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Aim: The metabolic behavior and the prognostic value of 18 F-FDG-PET/CT in gastrointestinal stromal tumor (GIST) is not well investigated. The aim of this study was to analyze the metabolic behavior of GIST and the prognostic role of pretreatment PET/CT features. Methods: In this retrospective study, we included 35 patients with a diagnosis of GIST who underwent a pretreatment 18 F-FDG-PET/CT scan. We analyzed PET images visually and semiquantitatively by measuring several metabolic parameters as the maximum standardized uptake value corrected for body weight (SUVbw), for lean body mass (SUVlbm), for body surface area (SUVbsa), metabolic tumor volume (MTV) and total lesion glycolysis (TLG). The Kaplan-Meier method was used to measure the progression free survival (PFS) and overall survival curves. Results: Twenty-nine (82%) patients showed a positive 18 F-FDG-PET/CT, whereas the remaining 6 had no hypermetabolic lesions. 18 F-FDG-avidity was significantly related with mitotic index, tumor stage and tumor risk group. Instead, semiquantitative PET/CT parameters correlated only with tumor risk group. Disease progression occurred in 16 patients whereas death in seven. 18 F-FDG-avidity, MTV and TLG were the only variables significantly associated with PFS. Conclusion: An 82% rate of PET avidity in GIST was found and it was correlated with stage, tumor risk group and mitotic index. Only baseline 18 F-FDG-avidity, MTV and TLG were independently correlated with PFS.

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Prognostic role of pretreatment 18F-FDG PET/CT in primary brain lymphoma

Cited by 42 publications

References 29 publications

Prognostic value of baseline ¹⁸F‐FDG PET/CT metabolic parameters in paediatric lymphoma

Prognostic value of baseline ¹⁸F‐FDG PET/CT metabolic parameters in paediatric lymphoma

Value of pretreatment 18F-FDG PET/CT in prognosis and the reflection of tumor burden: a study in pediatric patients with newly diagnosed neuroblastoma

Metabolic behavior and prognostic role of pretreatment 18F‐FDG PET/CT in gist

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Prognostic role of pretreatment 18F-FDG PET/CT in primary brain lymphoma

Cited by 42 publications

References 29 publications

Prognostic value of baseline 18F‐FDG PET/CT metabolic parameters in paediatric lymphoma

Prognostic value of baseline 18F‐FDG PET/CT metabolic parameters in paediatric lymphoma

Value of pretreatment 18F-FDG PET/CT in prognosis and the reflection of tumor burden: a study in pediatric patients with newly diagnosed neuroblastoma

Metabolic behavior and prognostic role of pretreatment 18F‐FDG PET/CT in gist

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Prognostic value of baseline ¹⁸F‐FDG PET/CT metabolic parameters in paediatric lymphoma

Prognostic value of baseline ¹⁸F‐FDG PET/CT metabolic parameters in paediatric lymphoma