Prognostic role of Nectin-4 expression in luminal B (HER2 negative) breast cancer

Rajc, Jasmina; Gugić, Damir; Fröhlich, Irena; Marjanović, Ksenija; Dumenčić, Boris

doi:10.1016/j.prp.2017.07.019

Cited by 26 publications

(20 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The abnormal expressions of both membranous and soluble forms of Nectin-4 have been found in human breast cancer tissues and sera from the patients. Furthermore, the levels of both two forms of Nectin-4 can be used as important biomarkers and prognostic predictors for breast cancer patients [11, 23, 24]. In human pancreatic carcinoma, the over-expression of Nectin-4 significantly promotes the proliferation of cancer cells and contributes to the intra-tumoral angiogenesis, and it can also be used as an important prognostic predictor for the patients [9].…”

Section: Discussionmentioning

confidence: 99%

Over-expression of Nectin-4 promotes progression of esophageal cancer and correlates with poor prognosis of the patients

et al. 2019

View full text Add to dashboard Cite

Background Nectin-4, also known as PVRL4 (poliovirus-receptor-like 4), is specifically expressed in the embryo and placenta. Recent studies have reported that the Nectin-4 is over-expressed in multiple human cancers, and such abnormal expression is associated with cancer progression and poor prognosis of the patients. In the present study, we aimed to characterize the expression pattern of Nectin-4 in human esophageal cancer (EC) tissues, and to investigate its clinical implications, prognostic value and regulatory effects on cellular functions of EC cells. Methods In the present study, we first examined Nectin-4 expression in human EC tissues by using immunohistochemistry (IHC) assay and analyzed the clinical associations. Then the cellular studies in vitro and the nude mice tumor model in vivo were used to examine the regulatory role of Nectin-4 in the progression of EC. Results Our results demonstrated that over-expression of Nectin-4 in human EC tissues was significantly associated with tumor size, depth of tumor invasion, and poor prognosis of the patients. The intervention of Nectin-4 expression in EC cell lines showed that the increased Nectin-4 expression could significantly promote the cell viability, migration, invasion and tumor formation. Conclusions Our present data unveiled that Nectin-4 played an important role in tumor biology and could serve as a useful prognostic predictor of human EC.

show abstract

Section: Discussionmentioning

confidence: 99%

Over-expression of Nectin-4 promotes progression of esophageal cancer and correlates with poor prognosis of the patients

et al. 2019

View full text Add to dashboard Cite

show abstract

“…The latter study was carried out by using the same polyclonal antibody applied in the present investigation. In several human cancers, Nectin immunostaining has been described as predominantly cytoplasmic or both membranous and cytoplasmic, although the significance of this different distribution is still debated. M‐Nectin‐4 expression was significantly associated with a lower metastasis‐free survival rate in breast cancer patients with luminal‐A (oestrogen receptor‐positive [ER+], and/or progesterone receptor‐positive [PR+], human epidermal growth factor receptor 2 [HER−]) tumours, whereas high c‐Nectin‐4 expression was significantly associated with higher rates of disease‐free survival and local relapse‐free survival.…”

Section: Discussionmentioning

confidence: 99%

“…The latter study was carried out by using the same polyclonal antibody applied in the present investigation. In several human cancers, 29 Nectin immunostaining has been described as predominantly cytoplasmic or both membranous and cytoplasmic, 30 Abbreviation: PC, prostatic carcinoma. Nectin 4 expression was classified as membranous (localized at cell-cell boundaries) or cytoplasmic (uniformly distributed throughout the cytoplasm).…”

Section: Discussionmentioning

confidence: 99%

Nectin‐4 and p63 immunohistochemical expression in canine prostate tumourigenesis

Salda

Massimini

Romanucci

et al. 2019

Vet Comparative Oncology

View full text Add to dashboard Cite

Nectin‐4 is an E‐cadherin‐based adherens junction protein of normal epithelial cells, as well as a potent mediator of anchorage‐independent cancer colony formation. It is considered a tumour‐associated histological and serological marker in various human cancers. The transcription factor p63 is a basal cell marker in the normal prostate, involved in cell adhesion, as well as in the formation and survival of circulating tumour cell clusters. The aim of this study was to evaluate Nectin‐4 and p63 immunohistochemical expression in 42 canine prostate tissues including 2 normal prostates, 10 benign prostatic hyperplasias (BPHs), 30 prostatic carcinomas (PCs), 1 pulmonary and 1 lymph node metastasis. From normal to neoplastic tissues, Nectin‐4 showed a progressive switching from membranous (m‐Nectin‐4) to cytoplasmic (c‐Nectin‐4), regardless of the histological subtypes, except for lack of expression in solid PCs. Metastatic cells exhibited both strong membranous and cytoplasmic positivity. c‐Nectin‐4 expression was significantly (P < 0.0001) increased in PCs/metastasis compared to BPHs cases and a decrease (P < 0.05) of nuclear p63 immunostaining was also detected in the two groups. Furthermore, data showed a significant association (P < 0.05) between p63 and m‐Nectin‐4 distribution, although their colocalization was detected only in scattered cells by double immunofluorescence. Our results suggest the involvement of m‐Nectin‐4 in canine prostate tumourigenesis and metastatic potential, while the exact role of c‐Nectin‐4 expression detectable in primary PCs requires further investigations.

show abstract

“… 18 , 19 34 More detailed analyses suggested importance of nectin-4 as a prognostic biomarker for breast cancer. 35 , 36 , 37 In addition, it is suggested that nectin-4 is a breast cancer stem cell marker. 38 Therefore, targeting nectin-4 is a promising strategy to treat breast cancer.…”

Section: Discussionmentioning

confidence: 99%

Recombinant SLAMblind Measles Virus Is a Promising Candidate for Nectin-4-Positive Triple Negative Breast Cancer Therapy

Fujiyuki

Amagai

Shoji

et al. 2020

Molecular Therapy - Oncolytics

View full text Add to dashboard Cite

One of the most refractory breast cancer types is triple negative (TN) breast cancer, in which cells are resistant to both hormone and Herceptin treatments and, thus, often cause recurrence and metastasis. Effective treatments are needed to treat TN breast cancer. We previously demonstrated that rMV-SLAMblind, a recombinant measles virus, showed anti-tumor activity against breast cancer cells. Here, we examined whether rMV-SLAMblind is effective for treating TN breast cancer. Nectin-4, a receptor for rMV-SLAMblind, was expressed on the surface of 75% of the analyzed TN breast cancer cell lines. rMV-SLAMblind infected the nectin-4-expressing TN breast cancer cell lines, and significantly decreased the viability in half of the analyzed cell lines in vitro . Additionally, intratumoral injection of rMV-SLAMblind suppressed tumor growth in xenografts of MDA-MB-468 and HCC70 cells. To assess treatment for metastatic breast cancer, we performed intravenous administration of the luciferase-expressing-rMV-SLAMblind to MDA xenografted mice. Virus replicated in the tumor and resulted in significant suppression of the tumor growth. The safety of the virus was tested by its intravenous injection into healthy cynomolgus monkeys, which did not cause any measles-like symptoms. These results suggest that rMV-SLAMblind is a promising candidate as a therapeutic agent for treating metastatic and/or TN type breast cancer.

show abstract

Prognostic role of Nectin-4 expression in luminal B (HER2 negative) breast cancer

Cited by 26 publications

References 25 publications

Over-expression of Nectin-4 promotes progression of esophageal cancer and correlates with poor prognosis of the patients

Over-expression of Nectin-4 promotes progression of esophageal cancer and correlates with poor prognosis of the patients

Nectin‐4 and p63 immunohistochemical expression in canine prostate tumourigenesis

Recombinant SLAMblind Measles Virus Is a Promising Candidate for Nectin-4-Positive Triple Negative Breast Cancer Therapy

Contact Info

Product

Resources

About