Prognostic role of microRNA-21 in various carcinomas: a systematic review and meta-analysis

Fu, Xiaonan; Han, Yong‐Jian; Wu, Ying; Zhu, Xiaoli; Lü, Xin; Mao, Feng; Wang, Xuejing; He, Xuelian; Zhao, Yuhang; Zhao, Yulan

doi:10.1111/j.1365-2362.2011.02535.x

Cited by 134 publications

(117 citation statements)

References 50 publications

(90 reference statements)

Supporting

Mentioning

109

Contrasting

Order By: Relevance

“…Our previous meta-analysis has shown that elevated expression of miR-21 was a predictor for worse outcome in a variety of cancers, especially in digestive system cancers and head and neck cancers [44]. In some studies, miR-155 was combined with miR-21 or a panel of miRNAs to predict survival [13,14,17,[34][35][36][37].…”

Section: Discussionmentioning

confidence: 99%

Prognostic Role of microRNA-155 in Various Carcinomas: Results from a Meta-Analysis

Zhang

et al. 2013

Disease Markers

Self Cite

View full text Add to dashboard Cite

Abstract. BACKGROUND:Recent studies have shown that microRNAs (miRNA) have prognostic values in cancers. This meta-analysis seeks to summarize the global predicting role of miR-155 for survival in patients with a variety of carcinomas. METHODS: Eligible studies were identified through multiple search strategies. Data were extracted from studies investigating the relationship between miR-155 expression and survival in cancer patients. Combined hazard ratios (HRs) of miR-155 for outcome were analyzed. RESULTS: A total of 16 studies dealing with various carcinomas were included for this meta-analysis. For overall survival, higher miR-155 expression could significantly predict worse outcome with the pooled HR of 2.057 (95% CI: 1.392-3.039). For relapse or progress-free survival, elevated miR-155 was also a significant predictor, with a combined HR of 1.918 (95% CI: 1.311-2.806,). In addition, subgroup analysis showed that higher expression of miR-155 had the trends to predict worse outcome in lung cancer. However, the HRs did not reach the statistical significance. CONCLUSION: Our findings suggest that miR-155 detection has a prognostic value in cancer patients. Regularly measuring miR-155 expression may be useful in clinical practice.

show abstract

Section: Discussionmentioning

confidence: 99%

Prognostic Role of microRNA-155 in Various Carcinomas: Results from a Meta-Analysis

Zhang

et al. 2013

Disease Markers

Self Cite

View full text Add to dashboard Cite

show abstract

“…In the present study, RT-qPCR analysis indicated that miR-21 expression was upregulated in BC tissues compared with that of normal bladder tissues. In particular, miR-21 has been shown to be involved in various cancer-associated processes, including cell growth, invasion and apoptosis (14). miR-21 induces hepatocellular carcinoma HepG2 cell proliferation via the suppression of mitogen-activated protein kinase-kinase 3 (15).…”

Section: Discussionmentioning

confidence: 99%

Expression and clinical significance of microRNA-21, maspin and vascular endothelial growth factor-C in bladder cancer

et al. 2015

View full text Add to dashboard Cite

“…Similarly, by analyzing the serum from 12 acute pancreatitis patients and three healthy controls, Liu et al [46] identified miR7 as one of the three diagnostic and prognostic biomarkers. Although several systematic reviews [44,[47][48][49] have investigated biomarkers for GC, none has shown that miR-7 could be a biomarker of GC.…”

Section: Circulatory Biomarkermentioning

confidence: 99%

Role of microRNA-7 in digestive system malignancy

Chen¹

2016

WJGO

View full text Add to dashboard Cite

There are several malignancies of the digestive system (including gastric, pancreatic and colorectal cancers, and hepatocellular carcinoma), which are the most common types of cancer and a major cause of death worldwide. MicroRNA (miR)-7 is abundant in the pancreas, playing an important role in pancreatic development and endocrine function. Expression of miR-7 is downregulated in digestive system malignancies compared with normal tissue. Although there are contrasting results for miR-7 expression, almost all research reveals that miR-7 is a tumor suppressor, by targeting various genes in specific pathways. Moreover, miR-7 can target different genes simultaneously in different malignancies of the digestive system. By acting on many cytokines, miR-7 is also involved in many gastrointestinal inflammatory diseases as a significant carcinogenic factor. Consequently, miR-7 might be a biomarker or therapeutic target gene in digestive system malignancies.

show abstract

Prognostic role of microRNA-21 in various carcinomas: a systematic review and meta-analysis

Abstract: Our findings suggest that miR-21 detection has a prognostic value in patients with cancer, especially in HNSCC and digestion system cancers.

Cited by 134 publications

References 50 publications

Prognostic Role of microRNA-155 in Various Carcinomas: Results from a Meta-Analysis

Prognostic Role of microRNA-155 in Various Carcinomas: Results from a Meta-Analysis

Expression and clinical significance of microRNA-21, maspin and vascular endothelial growth factor-C in bladder cancer

Role of microRNA-7 in digestive system malignancy

Contact Info

Product

Resources

About