Prognostic role of en-bloc resection and late onset of bone metastasis in patients with bone-seeking carcinomas of the kidney, breast, lung, and prostate: SSG study on 672 operated skeletal metastases

Ratasvuori, Maire; Wedin, Rikard; Hansen, Bjarne Hauge; Keller, Johnny; Trovik, Clement; Zaikova, Olga; Bergh, Peter; Kalén, Anders; Laitinen, Minna

doi:10.1002/jso.23654

Cited by 107 publications

(105 citation statements)

References 24 publications

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“…Solitary lesions can, in some cases (such as primary kidney cancer or bone sarcoma), be treated with curative, albeit generally palliative, intent. 7 Defining a difference between oligometastases and diffuse metastases throughout the skeleton is a relatively new concept. Especially for kidney and breast cancer patients, it is hypothesised that a more aggressive local treatment in the case of oligometastases might improve survival.…”

Section: Diagnosis and Evaluationmentioning

confidence: 99%

Treatment of pathological fractures of the long bones

et al. 2016

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Bone metastases of the long bones often lead to pain and pathological fractures. Local treatment consists of radiotherapy or surgery. Treatment strategies are strongly based on the risk of the fracture and expected survival.Diagnostic work-up consists of CT and biopsy for diagnosis of the primary tumour, bone scan or PET-CT for dissemination status, patient history and blood test for evaluation of general health, and biplanar radiograph or CT for evaluation of the involved bone.A bone lesion with an axial cortical involvement of >30 mm has a high risk of fracturing and should be stabilised surgically.Expected survival should be based on primary tumour type, performance score, and presence of visceral and cerebral metastases.Radiotherapy is the primary treatment for symptomatic lesions without risk of fracturing. The role of post-operative radiotherapy remains unclear.Main surgical treatment options consist of plate fixation, intramedullary nails and (endo) prosthesis. The choice of modality depends on the localisation, extent of involved bone, and expected survival. Adjuvant cement should be considered in large lesions for better stabilisation.Cite this article: Willeumier JJ, van der Linden YM, van de Sande MAJ, Dijkstra PDS. Treatment of pathological fractures of the long bones. EFORT Open Rev 2016;1:136–145. DOI: 10.1302/2058-5241.1.000008.

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Section: Diagnosis and Evaluationmentioning

confidence: 99%

Treatment of pathological fractures of the long bones

et al. 2016

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“…This finding was consistent across the various primary cancer types in this study. The importance of surgical margin on LR after bone metastasis surgery has been shown in renal cell carcinoma . Of note, time to LR showed a trend toward significance as being shorter in the curettage group than in the en‐bloc group (8.9 ± 10.7 months vs 15.5 ± 14.8 months, P = 0.113).…”

Section: Discussionmentioning

confidence: 86%

“…Although most patients with bone metastases to the extremities have a limited life expectancy of only a few months, a considerable proportion of patients live longer, even a few years . Moreover, ongoing improvements in systemic therapy are prolonging the life expectancy of patients with bone metastases . Given the increasing life expectancy of patients with bone metastases, durable surgical stabilization of bone metastases, which provides lifelong pain relief and functional recovery, is necessary .…”

Section: Introductionmentioning

confidence: 99%

Factors associated with local recurrence after surgery for bone metastasis to the extremities

Krishnan

Kim

Yun

et al. 2017

Journal of Surgical Oncology

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“…The quality of life of the patients and their everyday life are visibly improv ed. Repeat surgery is rarely required [7][8][9][10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%

Treatment Outcomes and Quality of Life after the Implantation of Modular Prostheses of the Proximal Femur in Patients with Cancer Metastases

Guzik¹

2016

Ortop Traumatol Rehabil

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STRESZCZENIEWstęp. Le cze nie ope ra cyj ne zła mań pa to lo gicz nych bli ższej czę ści ko ści udo wej z za sto so wa niem prę tów śród sz piko wych przy no si do bre krót ko trwa łe re zul ta ty, jed nak czę sto u cho rych z do brym ro ko wa niem, po cza sie do cho dzi do de sta bi li za cji ze spo leń i po trze by re ope ra cji. Lep sze dłu go trwa łe wy ni ki osią ga się sto su jąc pro te zy mo du lar ne.Ma te riał i me to dy. W la tach 2010-2014 w Od dzia le Or to pe dii On ko lo gicz nej w Brzo zo wie wy ko na no 64 ope ra cje resek cji gu zów prze rzu to wych bli ższej czę ści ko ści udo wej po łą czo nych z im plan ta cją pro tez mo du lar nych. Wska za niem do za sto so wa nia pro tez mo du lar nych by ły roz le głe ubyt ki ko ści obej mu ją ce na sa dę i przy na sa dę bli ższą ko ści udo wej i dobry stan ogól ny cho rych. Oce nia no stan cho rych, bó le w ska li VAS, spraw ność w ska li Kar no fsky'ego. Po ope ra cjach dodat ko wo oce nia no wy dol ność cho du i spraw no ści w ska lach MSTS oraz HHS. Ope ro wa no 38 ko biet i 26 mę żczyzn. Śred -nia wie ku ko biet wy nio sła 66 lat, mę żczyzn 69. Okres ob ser wa cji wy no sił od 3,6 do 1,2 ro ku, śred nio 1,8 ro ku.Wy ni ki: Im plan to wa no 28 pro tez GMRS -Stry ker oraz 36 MU TARS -Im plant Cast. Im plan ta cja w 19 przy padkach od by wa ła się z za sto so wa niem ce men tu kost ne go, na to miast w 45 bez je go uży cia.Wszy scy cho rzy po le cze niu ope ra cyj nym po da wa li po pra wę kom for tu ży cia. Śred nia war tość bó lu w ska li VAS wy nio sła 3,8, a spraw ność w skali Kar no fsky'ego 65. Wy dol ność cho dze nia i spraw ność oce nio na po 6 ty go dniach od ope ra cji w ska lach HHS i MSTS wy no si ła śred nio 75 i 20 pkt. Wszy scy pa cjen ci by li zdol ni do cho dze nia, więk szość bez po mo cy kul lub z 1 ku lą. Po wi kła nia ob ser wo wa no rzad ko. U jed ne go pa cjen ta do szło do ma syw nej wzno wy z ob lu zo wa niem pro te zy. Nie ob ser wo wa no głę bo kich in fek cji wy ma ga ją cych usu nię cia pro tez, ob lu zo wań ani zwich nięć.Wnio ski. 1. Le cze nie ope ra cyj ne prze rzu tów do ko ści z uży ciem pro tez mo du lar nych da je do bre wy ni ki. 2. Prote zy mo du lar ne ja ko roz wią za nie ope ra cyj ne zde cy do wa nie po pra wia ją ja kość ży cia a w ob ser wa cjach po ope ra cyj nych wy ka zu ją nie wiel ki po zy tyw ny pro gres. 3. Po wi kła nia w po sta ci in fek cji, ob lu zo wa nia czy wzno wy gu za w pre zen towa nym ma te ria le nie od bie ga ły od pre zen to wa nych w pi śmien nic twie.Słowa kluczowe: przerzuty do kości, resekcje guzów kości, protezoplastyka poresekcyjna kości SUMMARY Background. Surgical treatment of pathological fractures of the proximal femur with intramedullary rods produces good short-term outcomes, but after some time the fixation often becomes unstable in patients with a good prognosis and a repeat surgery is required. Modular prostheses allow for better long-term outcomes.Material and methods. A total of 64 surgical resection procedures for metastatic tumours of the proximal femur combined with t...

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Prognostic role of en-bloc resection and late onset of bone metastasis in patients with bone-seeking carcinomas of the kidney, breast, lung, and prostate: SSG study on 672 operated skeletal metastases

Abstract: This data summary is important tool for clinicians to evaluate survival and choose treatment options for patients suffering from metastatic bone disease.

Cited by 107 publications

References 24 publications

Treatment of pathological fractures of the long bones

Treatment of pathological fractures of the long bones

Factors associated with local recurrence after surgery for bone metastasis to the extremities

Treatment Outcomes and Quality of Life after the Implantation of Modular Prostheses of the Proximal Femur in Patients with Cancer Metastases

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