1998
DOI: 10.1002/(sici)1097-0142(19980901)83:5<1002::aid-cncr27>3.3.co;2-f
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Abstract: %EC and the presence or absence of VI appear to be reliable prognosticators to identify patients at high risk and low risk for occult retroperitoneal disease. In cases of clinical Stage I NSGCT, p53, bcl-2, MIB-1, cathepsin D, and E-cadherin did not appear to be of prognostic significance. The authors recommend that all patients with clinical Stage I NSGCT have their primary orchiectomy specimens evaluated for %EC and the presence of VI to determine their risk for occult retroperitoneal metastasis.

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Cited by 8 publications
(15 citation statements)
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“…In an earlier study by the same author (but in a different patient cohort), the pathological stage was correctly classified in 69% of cases (NPV 88%, PPV 55%) . These findings are contradicted by a series of 149 specimens by Heidenreich et al in which the MIB‐1 score was not useful in predicting the pathological stage. Gilbert et al used the same cut‐off values as the German trial and found no evidence of any prognostic value.…”
Section: Discussionmentioning
confidence: 85%
“…In an earlier study by the same author (but in a different patient cohort), the pathological stage was correctly classified in 69% of cases (NPV 88%, PPV 55%) . These findings are contradicted by a series of 149 specimens by Heidenreich et al in which the MIB‐1 score was not useful in predicting the pathological stage. Gilbert et al used the same cut‐off values as the German trial and found no evidence of any prognostic value.…”
Section: Discussionmentioning
confidence: 85%
“…Despite new-generation CT scans (helical CT with high resolution) and the introduction of positron emission tomography, the detection of small-volume metastases (Ͻ 10 mm) is unreliable. 6,7,11 The predominance of embryonal carcinoma in the primary tumor was proposed to be predictive of pulmonal metastases after RPLND. Another 10% of patients will develop metastases outside the retroperitoneum during follow-up, mostly in the lungs.…”
Section: Discussionmentioning
confidence: 99%
“…6,7,11,12 This is why a receiver operating curve analysis of the different cutoffs was not performed. 6,7,11,12 This is why a receiver operating curve analysis of the different cutoffs was not performed.…”
Section: Prediction Of Risk Groups Using Cutoff Valuesmentioning
confidence: 99%
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“…The best predictor in primary tumours is vascular invasion, but it is found only within a high‐risk group of patients with a relapse rate of 35% at a 2‐year follow‐up assessment 5,6 . Heidenreich et al 7 . have demonstrated that the percentage of embryonal carcinoma and the presence or absence of vascular invasion appear to be reliable prognosticators to identify patients at high risk and low risk of occult retroperitoneal disease.…”
Section: Introductionmentioning
confidence: 99%