Prognostic nutritional index predicts outcomes of malignant pleural mesothelioma

Yao, Zhou‐Hong; Tian, Guangyan; Wan, Yongqi; Kang, Yanmeng; Guo, Haisheng; Liu, Qinghua; Dong, Lin

doi:10.1007/s00432-013-1523-0

Cited by 70 publications

(51 citation statements)

References 27 publications

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“…NLR may present the pro-angiogenic/pro-inflammatory status in tumor tissue [10], and may also show how to balance neutrophils and lymphocytes, and then reflect patients' immune function [11, 12]. Preclinical studies showed that neutrophils may act through TGF-β induced signal pathway, with tumor promoting proliferation of leucocytes [13]. Patients with an elevated NLR exhibit the ratio of neutrophils and lymphocytes and may indirectly suggests poorer lymphocyte-mediated immune response to tumors, therefore, accelerating the process of tumor and prompting with worse prognosis [14].…”

Section: Discussionmentioning

confidence: 99%

Prognostic significance of neutrophil-lymphocyteratio/platelet-lymphocyteratioin lung cancers: a meta-analysis

Yang

Xing

et al. 2016

Oncotarget

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SettingFor now, hematological markers of inflammatory response have emerged as prognostic factors for patients with cancer. Many articles have confirm that neutrophil to lymphocyte ratio(NLR) and platelet–lymphocyte ratio (PLR) are relate with poor prognosis in various types of tumors.ObjectiveTo investigate the association between NLR/PLR and progression free survival (PFS), overall survival (OS) and clinicopathologic parameters in lung cancer patients.DesignWe performed relevant searches in PubMed database, Google Scholar, Springer Link. We included retrospective cohort studies that reported hazard ratios with 95% confidence intervals for the NLR or PLR and PFS or OS.ResultsBoth high NLR (P < 0.00001) and high PLR (P = 0.01) were significantly predictive of poorer OS. It also demonstrated that elevated NLR predicted poorer PFS (P = 0.0002). High NLR was significantly associated with deeper Invasive of tumor, (P = 0.006) extensive lymph nodetastasis(N2–3) (P = 0.01), poor differentiation (P = 0.0002) and vascular invasion(P = 0.002). There was no evidence of publication bias. Subgroup analysis indicated that little evidence of heterogeneity. However, PLR has no prognostic significance for SCLC.ConclusionsWe provides further evidence in support of elevated NLR and PLR were predictors of poor OS and PFS in patients with lung cancer. Given this, NLR and PLR may be markers to report treatment outcomes.

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Section: Discussionmentioning

confidence: 99%

Prognostic significance of neutrophil-lymphocyteratio/platelet-lymphocyteratioin lung cancers: a meta-analysis

Yang

Xing

et al. 2016

Oncotarget

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“…Identifying prognostic factors before surgery to help determine the optimal preoperative therapy and timing of surgery is important. Previous attempts have focused on a number of immuno-nutritional indices, including PNI, NLR, PLR, PI, and GPS [4,6,7,9,15,21,[25][26][27] . However, their reported prognostic value can vary between studies of the same cancer type; for example, in hepatocellular carcinoma, PLR was found to be a prognostic marker in one study, but another study suggested that only PNI was a prognostic marker [15] .…”

Section: Discussionmentioning

confidence: 99%

Novel immunological and nutritional-based prognostic index for gastric cancer

Sun

Chen

et al. 2015

WJG

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AIM:To assess the prognostic significance of immunological and nutritional-based indices, including the prognostic nutritional index (PNI), neutrophillymphocyte ratio (NLR), and platelet-lymphocyte ratio in gastric cancer. METHODS:We retrospectively reviewed 632 gastric cancer patients who underwent gastrectomy between 1998 and 2008. Areas under the receiver operating characteristic curve were calculated to compare the predictive ability of the indices, together with estimating the sensitivity, specificity and agreement rate. Univariate and multivariate analyses were performed to identify risk factors for overall survival (OS). Propensity score analysis was performed to adjust variables to control for selection bias. RESULTS:Each index could predict OS in gastric cancer patients in univariate analysis, but only PNI had independent prognostic significance in multivariate analysis before and after adjustment with propensity scoring (hazard ratio, 1.668; 95% confidence interval: 1.368-2.035). In subgroup analysis, a low PNI predicted a significantly shorter OS in patients with stage Ⅱ- Retrospective Study ORIGINAL ARTICLEⅢ disease (P = 0.019, P < 0.001), T3-T4 tumors (P < 0.001), or lymph node metastasis (P < 0.001). Canton score, a combination of PNI, NLR, and platelet, was a better indicator for OS than PNI, with the largest area under the curve for 12-, 36-, 60-mo OS and overall OS (P = 0.022, P = 0.030, P < 0.001, and P = 0.024, respectively). The maximum sensitivity, specificity, and agreement rate of Canton score for predicting prognosis were 84.6%, 34.9%, and 70.1%, respectively. CONCLUSION:PNI is an independent prognostic factor for OS in gastric cancer. Canton score can be a novel preoperative prognostic index in gastric cancer. Core tip: This is the first study to compare the prognostic significance of different immuno-nutritional indices including prognostic nutritional index (PNI), neutrophil-lymphocyte ratio (NLR) and plateletlymphocyte ratio (PLR) in gastric cancer. We found that PNI was an independent prognostic factor for overall survival in gastric cancer before and after the propensity score analysis, especially in patients with advanced disease, deep tumors, or lymph node metastasis. We also proposed that a new index-Canton score (a combination of PNI, NLR and PLT) is a superior prognostic factor compared to PNI, NLR, or PLR alone, as it better represents the relative contribution of each of these indices.Sun KY, Xu JB, Chen SL, Yuan YJ, Wu H, Peng JJ, Chen CQ, Guo P, Hao YT, He YL. Novel immunological and nutritionalbased prognostic index for gastric cancer.

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“…Mohri et al [7] demonstrated that preoperative PNI is a useful predictor of postoperative complications and survival in patients with colorectal cancer. Yao et al [19] showed that PNI, an indicator of nutritional status that is simple to construct from laboratory parameters, is a useful predictor of the long-term outcome of malignant pleural mesothelioma. However, the optimal cutoff value of the PNI to predict the long-term outcomes remains unclear.…”

Section: Table 3 Univariate and Multivariate Cox Regression Analyses mentioning

confidence: 99%

Prognostic nutritional index predicts postoperative complications and long-term outcomes of gastric cancer

Jiang¹,

Deng²,

Ding³

et al. 2014

WJG

131

116

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Prognostic nutritional index predicts outcomes of malignant pleural mesothelioma

Abstract: Pretreatment PNI is a novel independent prognostic factor in MPM.

Cited by 70 publications

References 27 publications

Prognostic significance of neutrophil-lymphocyteratio/platelet-lymphocyteratioin lung cancers: a meta-analysis

Prognostic significance of neutrophil-lymphocyteratio/platelet-lymphocyteratioin lung cancers: a meta-analysis

Novel immunological and nutritional-based prognostic index for gastric cancer

Prognostic nutritional index predicts postoperative complications and long-term outcomes of gastric cancer

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