Prognostic importance of lymph node yield after curative resection of gastroenteropancreatic neuroendocrine tumours

Chiramel, Jaseela; Almond, Rose; Slagter, Astrid E.; Khan, Adeel; Wang, Xin; Lim, Kok Haw Jonathan; Frizziero, Melissa; Chakrabarty, Bipasha; Minicozzi, Annamaria; Lamarca, Ángela; Mansoor, Wasat; Valle, Juan W.; McNamara, Mairéad G.

doi:10.5306/wjco.v11.i4.205

Cited by 5 publications

(2 citation statements)

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“…Previous studies have shown that LN status is the most important prognostic factor of PeCa, and its influence on the prognosis of the disease is more significant than that of the tumor grade, general appearance, morphology or microscopic pattern of the primary tumor (20)(21)(22)(23). ELN and LND are two basic aspects to determine the status of LNs, which are considered to be predictive factors for the survival of patients with other types of cancer (7,24). However, up to now, there is no suggestion about ELN count in the National Comprehensive Cancer Network (NCCN) PeCa Guide, although some studies tried to set a benchmark, and the results are not satisfactory (16,(25)(26)(27).…”

Section: Discussionmentioning

confidence: 99%

Impact of Examined Lymph Node Count and Lymph Node Density on Overall Survival of Penile Cancer

et al. 2021

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BackgroundFew studies have explored the optimal examined lymph node count and lymph node density cutoff values that could be used to predict the survival of patients with penile cancer. We further clarify the prognostic value of lymph node density and examined lymph node count in penile cancer.MethodsThe Surveillance, Epidemiology, and End Results (SEER) database was explored to recruit penile cancer patients from 2010 to 2015. A retrospective analysis of penile cancer patients’ data from the First Affiliated Hospital of Anhui Medical University was performed for verification (2006–2016). The cutoff values of examined lymph node count and lymph node density were performed according to the ROC curve. Kaplan-Meier survival analysis was used to compare survival differences among different groups. Univariate and multivariate Cox proportional hazard regression analyses were used to determine the significant variables. On the basis of Cox proportional hazards regression model, a nomogram was established and validated by calibration plot diagrams and concordance index (C-index).ResultsA total of 528 patients in the Surveillance, Epidemiology, and End Results cohort and 156 patients in the Chinese cohort were included in this study. Using the ROC curve, we found that the recommended cutoff values of ELN and LND were 13 and 9.3%, respectively (P <0.001). Kaplan–Meier curves suggested the significant differences of overall survival among different examined lymph nodes and lymph node density. Multivariate analysis indicated ELN and LND were independent prognostic factor for OS of penile cancer patients. Nomogram showed the contribution of ELN and LND to predicting OS was large. The C-index at 3-, and 5-year were 0.744 for overall survival (95% CI 0.711–0.777).ConclusionsThe more lymph nodes examined, the lower the density of lymph nodes, and the higher the long-term survival rate of penile cancer. We recommended 13 examined lymph nodes and lymph node density >9.3% as the cutoff value for evaluating the prognosis of penile cancer patients.

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Section: Discussionmentioning

confidence: 99%

Impact of Examined Lymph Node Count and Lymph Node Density on Overall Survival of Penile Cancer

et al. 2021

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“…Here is a summary of our main findings. G-NET is rare and LNM plays an immense role in the prognosis [ 7 ]. However, current guidelines fail to provide relevant recommendation to the risk evaluation and management of LNM.…”

Section: Discussionmentioning

confidence: 99%

Risk factors for lymph node metastasis in gastric neuroendocrine tumor: a retrospective study

Shao

et al. 2021

BMC Surg

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Background Lymph node metastasis (LNM) plays a vital role in the determination of clinical outcomes in patients with gastric neuroendocrine tumor (G-NET). Preoperative identification of LNM is helpful for intraoperative lymphadenectomy. This study aims to investigate risk factors for LNM in patients with G-NET. Methods We performed a retrospective study involving 37 patients in non-LNM group and 82 patients in LNM group. Data of demographics, preoperative lab results, clinical–pathological results, surgical management, and postoperative situation were compared between groups. Significant parameters were subsequently entered into logistic regression for further analysis. Results Patients in LNM group exhibited older age (p = 0.011), lower preoperative albumin (ALB) (p = 0.003), higher carcinoembryonic antigen (CEA) (p = 0.020), higher International normalized ratio (p = 0.034), longer thrombin time (p = 0.018), different tumor location (p = 0.005), higher chromogranin A positive rate (p = 0.045), and higher Ki-67 expression level (p = 0.002). Logistic regression revealed ALB (p = 0.043), CEA (p = 0.032), tumor location (p = 0.013) and Ki-67 (p = 0.041) were independent risk factors for LNM in G-NET patients. Conclusions ALB, CEA, tumor location, and Ki-67 expression level correlate with the risk of LNM in patients with G-NET.

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Prognostic factors for relapse in resected gastroenteropancreatic neuroendocrine neoplasms: A systematic review and meta-analysis

Broadbent

Wheatley

Stajer

et al. 2021

Cancer Treatment Reviews

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Prognostic importance of lymph node yield after curative resection of gastroenteropancreatic neuroendocrine tumours

Cited by 5 publications

References 36 publications

Impact of Examined Lymph Node Count and Lymph Node Density on Overall Survival of Penile Cancer

Impact of Examined Lymph Node Count and Lymph Node Density on Overall Survival of Penile Cancer

Risk factors for lymph node metastasis in gastric neuroendocrine tumor: a retrospective study

Prognostic factors for relapse in resected gastroenteropancreatic neuroendocrine neoplasms: A systematic review and meta-analysis

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