Prognostic impact of tumour-associated B cells and plasma cells in oesophageal and gastric adenocarcinoma

Fristedt, Richard; Borg, David; Hedner, Charlotta; Berntsson, Jonna; Nodin, Björn; Eberhard, Jakob; Micke, Patrick; Jirström, Karin

doi:10.21037/jgo.2016.11.07

Cited by 52 publications

(53 citation statements)

References 43 publications

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“…In 2 of 5 studies, IGKC þ cells were associated with a positive prognostic effect, whereas CD138 þ cells showed no significant association with outcome (12,35). In two other studies, CD138 þ cells showed a positive (35) or negative (38) prognostic effect, whereas IGKC þ cells were neutral. Only 1 of 5 studies found a concordant prognostic effect (positive) for CD138 þ and IGKC þ cells (colorectal cancer; ref.…”

Section: Plasma Cellsmentioning

confidence: 95%

“…Four studies showed a positive prognostic effect of CD138 þ cells (colorectal cancer, esophageal and gastric cancer, and melanoma; refs. 24,35,43,45), 2 studies found a neutral effect (esophageal cancer and NSCLC; refs. 12,35), and 3 studies showed a negative effect (breast and ovarian cancers, and melanoma; refs.…”

Section: Plasma Cellsmentioning

confidence: 99%

“…24,35,43,45), 2 studies found a neutral effect (esophageal cancer and NSCLC; refs. 12,35), and 3 studies showed a negative effect (breast and ovarian cancers, and melanoma; refs. 21,38,58).…”

Section: Plasma Cellsmentioning

confidence: 99%

“…In 5 of 7 cohorts, a positive prognostic effect was found (NSCLC, colorectal cancer, esophageal and two studies in breast cancer; refs. 12,24,35,59,60), although two studies found no association with survival (gastric and ovarian cancer) (35,38). Four of the positive studies performed a multivariate survival analysis with clinicopathologic characteristics, and 3 of 4 found IGKC þ cells to be an independent prognostic factor (NSCLC, esophageal, and breast cancer; refs.…”

Section: Plasma Cellsmentioning

confidence: 99%

“…Four of the positive studies performed a multivariate survival analysis with clinicopathologic characteristics, and 3 of 4 found IGKC þ cells to be an independent prognostic factor (NSCLC, esophageal, and breast cancer; refs. 12,24,35,59).…”

Section: Plasma Cellsmentioning

confidence: 99%

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Prognostic Significance of Tumor-Infiltrating B Cells and Plasma Cells in Human Cancer

Wouters¹,

Nelson

2018

Clinical Cancer Research

337

262

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There is abundant evidence that tumor-infiltrating CD8 T cells contribute positively to antitumor immunity; however, the role of tumor-infiltrating B cells (TIL-B) and plasma cells (PC) remains controversial, leading to differing opinions about whether immunotherapies should be designed to enhance or inhibit these cells. Through a comprehensive PubMed search, we reviewed publications with cohorts of 50 or more cases in which the prognostic value of TIL-B/PC was assessed by immunohistochemistry and/or gene-expression analysis. Sixty-nine studies representing 19 cancers met our review criteria. The large majority of studies assessed TIL-B by immunohistochemical detection of CD20. Of these, 50.0% reported a positive prognostic effect for CD20 TIL-B, whereas the remainder found a neutral (40.7%) or negative (9.3%) effect. These differences in prognostic effect were not attributable to cancer type, other clinicopathologic factors, or differing technical approaches. The prognostic significance of TIL-B/PC was generally concordant with that of CD3 and/or CD8 T cells, and the prognostic effect of T cells was generally stronger when TIL-B and/or PC were also present. Additionally, 21 studies inferred the presence of TIL-B/PC from gene-expression data, and a large majority reported a positive prognostic effect. Although more studies are required involving additional cancer types and independent patient cohorts, the weight of evidence supports a positive role for TIL-B and PC in antitumor immunity, suggesting that enhancement of these responses should be considered in the design of cancer immunotherapies.

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Section: Plasma Cellsmentioning

confidence: 95%

Section: Plasma Cellsmentioning

confidence: 99%

Section: Plasma Cellsmentioning

confidence: 99%

Section: Plasma Cellsmentioning

confidence: 99%

Section: Plasma Cellsmentioning

confidence: 99%

See 3 more Smart Citations

Prognostic Significance of Tumor-Infiltrating B Cells and Plasma Cells in Human Cancer

Wouters¹,

Nelson

2018

Clinical Cancer Research

337

262

View full text Add to dashboard Cite

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Transinteractome analysis reveals distinct niche requirements for isotype‐based plasma cell subsets in the bone marrow

et al. 2023

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Bone marrow (BM) long‐lived plasma cells (PCs) are essential for long‐term protection against infection, and their persistence within this organ relies on interactions with Cxcl12‐expressing stromal cells that are still not clearly identified. Here, using single cell RNAseq and in silico transinteractome analyses, we identified Leptin receptor positive (LepR+) mesenchymal cells as the stromal cell subset most likely to interact with PCs within the BM. Moreover, we demonstrated that depending on the isotype they express, PCs may use different sets of integrins and adhesion molecules to interact with these stromal cells. Altogether, our results constitute an unprecedented characterization of PC subset stromal niches and open new avenues for the specific targeting of BM PCs based on their isotype.

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Drug metabolism‐related eight‐gene signature can predict the prognosis of gastric adenocarcinoma

Yin

Chen

et al. 2021

Clinical Laboratory Analysis

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Prognostic impact of tumour-associated B cells and plasma cells in oesophageal and gastric adenocarcinoma

Abstract: These results demonstrate, for the first time, that abundant infiltration of IGKC+ plasma cells independently predicts a prolonged survival in both oesophageal and gastric cancer.

Cited by 52 publications

References 43 publications

Prognostic Significance of Tumor-Infiltrating B Cells and Plasma Cells in Human Cancer

Prognostic Significance of Tumor-Infiltrating B Cells and Plasma Cells in Human Cancer

Transinteractome analysis reveals distinct niche requirements for isotype‐based plasma cell subsets in the bone marrow

Drug metabolism‐related eight‐gene signature can predict the prognosis of gastric adenocarcinoma

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