2008
DOI: 10.1038/sj.bjc.6604400
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Abstract: Carcinoma cells lack syndecan-1 expression when they are transiting from an epithelial to a less-differentiated mesenchymal phenotype (epithelial -mesenchymal transition, EMT). Furthermore, a shift of syndecan-1 expression from malignant epithelial cells to reactive stromal cells has also been observed during progression of many carcinomas. Finally, epithelial and/or stromal syndecan-1 expression is of prognostic value in many carcinomas. Because recent results are contradictory in breast carcinomas, we have r… Show more

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Cited by 68 publications
(70 citation statements)
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“…Tspan7 was reported to behave either as a metastasis suppressor or as a marker of poor prognosis in AML, depending on the cell system (22,23). Loss of Sdc1, which appears to be negatively regulated by Stat3, correlates with higher malignancy of ductal breast cancer cells and with epithelial to mesenchimal transition of epithelial cancer cells (24). Gadd45b is a prosurvival factor associated to stress resistance in tumors and its overexpression can transform NIH 3T3 fibroblasts (25).…”
Section: Discussionmentioning
confidence: 99%
“…Tspan7 was reported to behave either as a metastasis suppressor or as a marker of poor prognosis in AML, depending on the cell system (22,23). Loss of Sdc1, which appears to be negatively regulated by Stat3, correlates with higher malignancy of ductal breast cancer cells and with epithelial to mesenchimal transition of epithelial cancer cells (24). Gadd45b is a prosurvival factor associated to stress resistance in tumors and its overexpression can transform NIH 3T3 fibroblasts (25).…”
Section: Discussionmentioning
confidence: 99%
“…(Cancer Sci 2009; 100: 2101-2108) I t has recently been reported that the gene expression and protein expression profiles of the tumor stroma play very important roles in tumor progression in carcinoma, (1)(2)(3) and the interaction between tumor and stromal cells also plays a very important role in tumor progression by carcinoma. (4)(5)(6) We and others have already reported that a characteristic histological feature of tumor stroma, a fibrotic focus, is a very useful prognostic histological tumor stromal indicator for accurately predicting the outcome of patients with invasive ductal carcinoma (IDC), (7)(8)(9)(10) and that growth factors produced by tumor cells and tumor stromal cells play a very important role in tumor progression by IDC. (11) In addition, proliferative activity of tumor stromal fibroblasts plays a very important role in nodal metastasis and distant organ metastasis by IDC.…”
mentioning
confidence: 99%
“…a plasma membrane integrated protein substituted with CS and/or HS, and concomitant induction of stromal syndecan-1 expression is associated with epithelial-mesenchymal transition and, accordingly, worse prognosis of breast cancer (32). It is currently unknown which CSPG core protein/s is specifically associated with CS chains harbouring the CS-56 antibody epitope, and whether increased tumor aggressiveness is related to altered expression and/or degree of glycosylation of a particular PG in malignant cells.…”
Section: Discussionmentioning
confidence: 99%
“…The role of CSPG core proteins in cancer has, however, been extensively studied, both experimentally and in clinical tumor specimens from various cancer types (15,(25)(26)(27)(28)(29)(30)(31)(32)(33)(34). In breast cancer, versican, i.e.…”
Section: Discussionmentioning
confidence: 99%