Prognostic impact of preoperative NLR and CA19-9 in pancreatic cancer

Asaoka, Tadafumi; Miyamoto, Atsushi; Maeda, Sakae; Tsujie, Masanori; Hama, Naoki; Yamamoto, Keiji; Miyake, Masakazu; Haraguchi, Naotsugu; Nishikawa, Kazuhiro; Hirao, Motohiro; Ikeda, Masataka; Sekimoto, Mitsugu; Nakamori, Shoji

doi:10.1016/j.pan.2015.10.006

Cited by 106 publications

(90 citation statements)

References 34 publications

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“…The NLR is deﬁned as neutrophil counts divided by lymphocyte counts. The prognostic value of NLR has been confirmed in patients with colorectal cancer [3], hepatocellular carcinoma [4], breast cancer [5], bladder cancer [6], lung cancer [7], and pancreatic cancer [8]. In urologic cancer, a high NLR was significantly associated with worse overall survival (OS) [9, 10].…”

Section: Introductionmentioning

confidence: 99%

The Role of Neutrophil-Lymphocyte Ratio, Platelet-Lymphocyte Ratio, and Platelets in the Prognosis of Metastatic Renal Cell Carcinoma

et al. 2019

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Objective(s): The aim of this analysis was to evaluate the platelet-lymphocyte ratio (PLR), neutrophil-lymphocyte ratio (NLR), platelets (PLT), and neutrophil level for their prognostic value in patients with metastatic renal cell carcinoma (mRCC). Materials: We retrospectively reviewed medical records of 141 patients with mRCC (2006–2016). Univariate and multivariate analyses were performed with the Cox proportional hazards regression model. The cutoff value of NLR was “elevated” as >3.68 and the PLR cutoff value was “elevated” as >144.4. Results: The median PFS and OS were shorter in elevated NLR and PLR. A higher value of PLT was associated with worse median OS and higher neutrophil level with worse OS and PFS. In multivariate analysis, higher NLR (p = 0.007) and PLR (p = 0.006) were independent prognostic factors for shorter OS together with BMI ≤30 (p = 0.004), higher Fuhrman grade (p = 0.0002), lower level of hemoglobin (p= 0.010), and ZUBROD 2 (p = 0.0002). Higher PLR (p = 0.0002) was an independent negative prognostic factor for PFS together with higher Fuhrman grade (p = 0.001), higher neutrophil level (p = 0.001), and lower lymphocyte level (p = 0.013). Conclusion: Elevated pretreatment NLR, PLR, PLT, and neutrophil count are associated with shorter OS and PFS in patients with mRCC. NLR and PLR are independent prognostic factors for OS. However, PLR and neutrophil count are independent prognostic factors for PFS.

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Section: Introductionmentioning

confidence: 99%

The Role of Neutrophil-Lymphocyte Ratio, Platelet-Lymphocyte Ratio, and Platelets in the Prognosis of Metastatic Renal Cell Carcinoma

et al. 2019

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“…Initially, the cohort was explored primarily for the interest of investigating isolated liver recurrences, which were not found as a frequent problem in the series. In the current series, results from the tumour marker CA 19.9 were not available, that may have declared unfavourable disease in some patients 16 . Attempts to further explore small subgroups or more granular details of clinical or pathological factors was not made, to .…”

Section: Discussionmentioning

confidence: 80%

Patterns of recurrence after curative-intent surgery for pancreas cancer reinforce the importance of locoregional control and adjuvant chemotherapy

Munir

Søreide

Rajan

et al. 2018

Preprint

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“…Among these, NLR is most well known as a marker of poor prognosis in DFS or OS for various malignant tumours, as well as for poor response to chemotherapy or radiotherapy and IL‐2 immunotherapy response in renal cell carcinoma. Cancer‐related systemic inflammation has been correlated with the characteristics of advanced and more aggressive tumour types, including larger tumour size and poorer tumour differentiation …”

Section: Discussionmentioning

confidence: 99%

Prognostic impact of the combination of the neutrophil‐to‐lymphocyte ratio and serum carbohydrate antigen 19‐9 in patients with pancreas head cancer

Kim

Lim

Park

et al. 2019

ANZ Journal of Surgery

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Background This study aimed to evaluate the clinical value of the combination of a traditional prognostic factor with a systemic inflammation‐based prognostic factor in patients undergoing curative resection for pancreas head cancer diagnosed as pancreatic ductal adenocarcinoma. Methods From January 2005 to December 2015, 198 patients were enrolled. Various clinicopathological factors potentially associated with survival and recurrence were evaluated in this study. Results The selected cut‐off values for the test prognostic factors with sufficient sensitivity and specificity were 2.8 for the neutrophil‐to‐lymphocyte ratio (NLR) and 70 U/mL for serum carbohydrate antigen 19‐9 (CA19‐9). Kaplan–Meier survival analysis demonstrated that the 5‐year survival rate in patients with a high NLR and CA19‐9 was 21.8% compared with 79.8% for patients with a low NLR and CA19‐9. The 5‐year disease‐free survival rate in patients with a high NLR and CA19‐9 was 0% compared with 33.9% for patients with a low NLR and CA19‐9. Patients with high NLRs and high CA19‐9 were more likely to have an early recurrence and multiple relapse patterns. Conclusion Preoperative NLR and serum CA19‐9 offer significant prognostic information for survival following curative resection of pancreas head cancer diagnosed as pancreatic ductal adenocarcinoma.

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Prognostic impact of preoperative NLR and CA19-9 in pancreatic cancer

Cited by 106 publications

References 34 publications

The Role of Neutrophil-Lymphocyte Ratio, Platelet-Lymphocyte Ratio, and Platelets in the Prognosis of Metastatic Renal Cell Carcinoma

The Role of Neutrophil-Lymphocyte Ratio, Platelet-Lymphocyte Ratio, and Platelets in the Prognosis of Metastatic Renal Cell Carcinoma

Patterns of recurrence after curative-intent surgery for pancreas cancer reinforce the importance of locoregional control and adjuvant chemotherapy

Prognostic impact of the combination of the neutrophil‐to‐lymphocyte ratio and serum carbohydrate antigen 19‐9 in patients with pancreas head cancer

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