Prognostic factors of gastroesophageal reflux disease in congenital diaphragmatic hernia: a multicenter study

Terui, Keita; Taguchi, Tomoaki; Goishi, Keiji; Hayakawa, Masahiro; Tazuke, Yuko; Yokoi, Akiko; Takayasu, Hajime; Okuyama, Hiroomi; Yoshida, Hideo; Usui, Noriaki

doi:10.1007/s00383-014-3594-7

Cited by 14 publications

(7 citation statements)

References 18 publications

(29 reference statements)

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“…Various factors may be associated with poor growth during infancy, including the fact that patients with CDH are sometimes intolerant to EN due to cardiorespiratory instability, deep sedation, or restrictions in volume loading. GER, oral aversion, and allergies can also contribute to difficulties in enteral feeding [14,15]. We previously reported that EN and supportive PN in the acute phase were essential for weight gain during infancy [16].…”

Section: Discussionmentioning

confidence: 99%

Weight gain velocity and adequate amount of nutrition for infants with congenital diaphragmatic hernia

et al. 2020

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Purpose Growth retardation is a severe morbidity in infants with congenital diaphragmatic hernia (CDH). This study aimed to determine when catch-up growth starts in infants with CDH and to determine the adequate amount of nutrition required during catch-up growth. Methods This was a multicenter retrospective cohort study involving neonates with isolated CDH (born 2006-2010; n = 98). Weight gain velocity (WGV) was calculated using body weight Z-scores. The minimum required weight gain was defined as WGV ≥ 0. Patients were dichotomized into severe and non-severe cases according to diaphragmatic defects. Results Average monthly WGV changed from < 0 to ≥ 0 at 2 months of age. Total caloric intake at 2 months of age was lower when the WGV between 1 and 3 months was < 0 in both severe cases [122 (95% confidence interval (CI) 116-128) vs. 97 (95% CI 84-110) kcal/kg/day, p = 0.02] and non-severe cases [115 (95% CI 110-120) vs. 99 (95% CI 87-111) kcal/ kg/day, p < 0.001)]. Conclusion Catch-up growth started at approximately 2 months of age. During this period, total caloric intake of > 122 kcal/ kg/day was needed to avoid decreases in the body weight Z-score in severe cases.

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Section: Discussionmentioning

confidence: 99%

Weight gain velocity and adequate amount of nutrition for infants with congenital diaphragmatic hernia

et al. 2020

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“…The CDH patients, however, are sometimes intolerant to EN due to cardiorespiratory instability, deep sedation, or restrictions in volume loading. Gastroesophageal reflux and allergies can also contribute to difficulties in enteral feeding . Therefore, the amount of EN received is often affected by the severity of CDH.…”

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confidence: 99%

“…Gastroesophageal reflux and allergies can also contribute to difficulties in enteral feeding. 7,8 Therefore, the amount of EN received is often affected by the severity of CDH. Controversy also surrounds the appropriate timing and dose of supportive parenteral nutrition (PN) in the acute phase.…”

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Impact of nutrition in the treatment of congenital diaphragmatic hernia

Terui

Usui

Tazuke

et al. 2019

Pediatrics International

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Background The optimum enteral (EN) and parenteral nutrition (PN) regimens during acute management of congenital diaphragmatic hernia (CDH) remain unclear. We examined the effects of EN and PN on weight gain in CDH patients. Methods A multicenter retrospective cohort study of neonates with CDH (born 2006–2010; n = 105) who survived to discharge was conducted. Patients were divided as receiving PN ≥ or <50 kcal/kg/day at 1 week of age, and EN ≥ or <60 kcal/kg/day at 2 weeks of age. Changes in bodyweight at 30, 60, and 90 days of age were compared. Results The higher EN group (n = 39) had greater mean weight gain than the lower EN group (n = 66; 90 days: 2,501 g, 95% CI: 2,294–2,710 g vs 1,706 g, 95% CI: 1,553–1,861 g; P <0.001). When patients received lower EN, the higher PN group (n = 24) had greater mean weight gain than the lower PN group (n = 42; 90 days: 1,768 g, 95% CI: 1,574–1,961 g vs 1,411 g, 95% CI: 1,264–1,558 g; P = 0.004). Conclusion The amount of EN in the acute phase of CDH management is essential for weight gain during infancy. When patients are intolerant to adequate EN, supportive PN is also essential.

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“…Identified risk factors include antenatal diagnosis, intrathoracic liver position, patch closure, stomach position, esophageal dysmotility, and tube feeding at discharge. [98][99][100] Gastrointestinal symptoms (GERD, FTT, and OA) are associated with a longer hospital course, prolonged mechanical ventilation, and a longer need for parenteral nutrition. 101 The diagnostic approach for suspected GERD in infants with CDH should be based on standard guidelines.…”

Section: Literature Review Pulmonary Function a Literature Overview mentioning

confidence: 99%

Defining outcomes following congenital diaphragmatic hernia using standardised clinical assessment and management plan (SCAMP) methodology within the CDH EURO consortium

et al. 2018

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Treatment modalities for neonates born with congenital diaphragmatic hernia (CDH) have greatly improved in recent times with a concomitant increase in survival. In 2008, CDH EURO consortium, a collaboration of a large volume of CDH centers in Western Europe, was established with a goal to standardize management and facilitate multicenter research. However, limited knowledge on long-term outcomes restricts the identification of optimal care pathways for CDH survivors in adolescence and adulthood. This review aimed to evaluate the current practice of long-term follow-up within the CDH EURO consortium centers, and to review the literature on long-term outcomes published from 2000 onward. Apart from having disease-specific morbidities, children with CDH are at risk for impaired neurodevelopmental problems and failure of educational attainments which may affect participation in society and the quality of life in later years. Thus, there is every reason to offer them long-term multidisciplinary follow-up programs. We discuss a proposed collaborative project using standardized clinical assessment and management plan (SCAMP) methodology to obtain uniform and standardized follow-up of CDH patients at an international level.

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Prognostic factors of gastroesophageal reflux disease in congenital diaphragmatic hernia: a multicenter study

Abstract: Diaphragmatic defect of more than 75% was risk factor of future need for antireflux surgery.

Cited by 14 publications

References 18 publications

Weight gain velocity and adequate amount of nutrition for infants with congenital diaphragmatic hernia

Weight gain velocity and adequate amount of nutrition for infants with congenital diaphragmatic hernia

Impact of nutrition in the treatment of congenital diaphragmatic hernia

Defining outcomes following congenital diaphragmatic hernia using standardised clinical assessment and management plan (SCAMP) methodology within the CDH EURO consortium

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