Prognostic Factors of Colorectal Cancer Liver Metastasis

Coimbra, Felipe José Fernández; Brandão, Paulo Henrique Miranda; Diniz, Alessandro Landskron; Ribeiro, Héber Salvador de Castro; Júnior, Wilson Luiz da Costa; Godoy, A.; Farias, Igor Correia de

doi:10.1007/978-3-030-25486-5_7

Cited by 1 publication

(7 citation statements)

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“…The management of CLM has seen a marked change over the last decade, owing to the advancement of surgical techniques and perioperative treatments[ 3 ]. The achievement of curative resection of liver metastasis has transformed the 5-year survival from 11% to a range of 36%-60%[ 2 - 4 ]. The current study demonstrated a 5-year overall survival rate of 35.5%, slightly lower than the reported survival rate.…”

Section: Discussionmentioning

confidence: 99%

“…Many studies have investigated the prognostic factors of survival after resection of CLM. The most frequently cited prognostic factors are the number and the largest size of CLM, regional lymph node metastasis of the primary tumor, and preoperative CEA level[ 2 ]. Other proposed factors included disease-free interval from the treatment of primary CRC, location of primary CRC, and surgical resection margin[ 4 , 11 , 12 ].…”

Section: Discussionmentioning

confidence: 99%

“…Colorectal cancer (CRC) is the third leading cause of cancer-related death in developed countries[ 1 ]. About half of the cases will develop liver metastasis, and 25% of them will present synchronously[ 2 ]. Hepatic resection has become the standard management in selected patients, with a reported 5-year survival rate ranging from 36% to 60% after curative liver resection[ 2 - 4 ].…”

Section: Introductionmentioning

confidence: 99%

“…About half of the cases will develop liver metastasis, and 25% of them will present synchronously[ 2 ]. Hepatic resection has become the standard management in selected patients, with a reported 5-year survival rate ranging from 36% to 60% after curative liver resection[ 2 - 4 ]. Yet, this is a heterogeneous group of patients with variable prognoses[ 2 ].…”

Section: Introductionmentioning

confidence: 99%

“…Hepatic resection has become the standard management in selected patients, with a reported 5-year survival rate ranging from 36% to 60% after curative liver resection[ 2 - 4 ]. Yet, this is a heterogeneous group of patients with variable prognoses[ 2 ]. As such, many studies have been directed towards the investigation of factors that might influence the recurrence and survival of patients with colorectal liver metastasis (CLM), with a goal to differentiate patients that would best benefit from surgical resection from those who should be directed to palliative care[ 5 - 8 ].…”

Section: Introductionmentioning

confidence: 99%

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Prognostic factors of survival and a new scoring system for liver resection of colorectal liver metastasis

Cheng¹,

Yip²

2022

WJH

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BACKGROUND Hepatic resection has become the preferred treatment of choice for colorectal liver metastasis (CLM) patients. AIM To identify the prognostic factors and to formulate a new scoring system for management of CLM. METHODS Clinicopathologic and long-term survival data were analyzed to identify the significant predictors of survival by univariate and multivariate analyses with the Cox model. A clinical score was constructed based on the analysis results. RESULTS Three factors of worse overall survival were identified in the multivariate analysis. They were number of liver metastases ≥ 5, size of the largest liver lesion ≥ 4 cm, and the presence of nodal metastasis from the primary tumor. These three factors were chosen as criteria for a clinical risk score for overall survival. The clinical score highly correlated with median overall survival and 5-year survival ( P = 0.002). CONCLUSION Priority over surgical resection should be given to the lowest score groups, and alternative oncological treatment should be considered in patients with the highest score.

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Section: Discussionmentioning

confidence: 99%