Prognostic factors in pediatric spinal cord astrocytoma

Bouffet, Éric; Pierre-Kahn, Alain; Marchal, J. C.; Jouvet, Anne; Kalifa, Chantal; Choux, M; Dhellemmes, P; Guérin, J.; Trémoulet, M; Mottolèse, C.

doi:10.1002/(sici)1097-0142(19981201)83:11<2391::aid-cncr20>3.0.co;2-0

Cited by 97 publications

(82 citation statements)

References 30 publications

(35 reference statements)

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“…A large multicenter review of pediatric patients with intramedullary astrocytomas conducted in France reported age \7 years to correlate with better outcome. Ten-year OS for younger patients was 76% compared with 38% for patients older than 7 years (p = 0.04) [5]. Contrary to these four reports, the last category A study [49] reported age over 20 to be associated with increased survival.…”

Section: Agementioning

confidence: 83%

“…Results of a statistical analysis of age as a prognostic factor were reported in 15 studies [2,5,24,27,28,30,34,41,46,49,56,59,60,64,65] (Table 4). Of these, 13 were classified as category A, 8 failed to find a significant relationship between age and prognosis [2,24,28,30,34,46,56,59], as did one additional category B study [27].…”

Section: Agementioning

confidence: 99%

“…Of these, nine were classified as category A, six failed to find a significant association between gender and prognosis [2,34,41,49,59,60], as did two additional category B studies [27,65]. Two category A [5].…”

Section: Gendermentioning

confidence: 99%

“…Of these, eight were classified as category A, five failed to identify significant relationship between history length and outcome [24,30,34,59,64], as did one additional category B study [22]. Three category A studies in agreement reported increased survival in patients with history length longer than 2 months [5] and 6 months [49,60]. In addition, one category B study reported decreased 5-year OS in patients with history length shorter than 1 year [27].…”

Section: History Lengthmentioning

confidence: 99%

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Prognostic factors in intramedullary astrocytomas: a literature review

2009

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Astrocytomas affect a significant portion of patients with intramedullary tumors. These infiltratively growing tumors are treated by a variety of methods-biopsy and decompressive surgery, maximal safe resection, adjuvant oncological therapy. Also, numerous prognostic factors are reported in the literature. Better understanding of factors that influence prognosis may help in treatment planning with the goal of prolonging survival. We have thus undertaken an extensive literature review in order to define factors affecting prognosis. A total of 38 articles were studied. Only tumor grade was consistently reported as the major factor affecting prognosis. The influence of other clinical factors (age, gender, history length, functional status, tumor location or extent, syrinx or cyst presence) can be speculated upon, but cannot be assessed adequately from the available literature. For both low-and high-grade (HG) astrocytomas, maximal safe tumor resection should be the primary treatment objective but is often not feasible in contrast to other intramedullary and spinal neoplasms. Since the biological nature of spinal cord HG glioma is identical to that of the brain, the same treatment algorithm of maximal safe resection followed by concomitant radio-and chemotherapy would be sensible to implement.

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Section: Agementioning

confidence: 83%

Section: Agementioning

confidence: 99%

Section: Gendermentioning

confidence: 99%

Section: History Lengthmentioning

confidence: 99%

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Prognostic factors in intramedullary astrocytomas: a literature review

2009

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“…This is consistent with previous studies of malignant spinal tumours. 6,11 Spinal cord glioblastomas occur mainly in the cervical or thoracic segments. 9,10,[12][13][14][15][16][17][18][19] In our case glioblastoma was localised at T 9 -T 11 .…”

Section: Case Reportmentioning

confidence: 99%

Spinal glioblastoma with brain relapse in a child: clinical considerations

2005

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Case report: Spinal cord glioblastoma in children has only rarely been reported. It most frequently involves the thoracic region with a predilection for the second and third decades of life. This report describes one case of thoracic glioblastoma multiforme in a 6-year-old child and reviews other cases reported in the literature. Results: Laminectomy and excision of the tumour were performed. Postoperative radiotherapy and chemotherapy were given, but 4 months later the patient presented with a brain relapse of the tumour. At 9 months after diagnosis the patient died from cerebral tumour regrowth. Conclusions: Full neuraxis MRI is always recommended in order to detect possible metastases. The prognosis after multimodality therapy (surgery, radiotherapy, chemotherapy) remains poor. From the literature, only four cases of paediatric patients with long-term survival have been reported.

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