Prognostic factors in inoperable adenocarcinoma of the lung: A multivariate regression analysis in 259 patients

Pretreatment Prognostic Factors for Survival in Non-Small-Cell Lung Cancer: A Multivariate Analysis of 229 Patients

“…1). Our findings support the results of other studies [10,11,23], despite variable clinical groups of patients and differences in index design. In the study published by Shinkai et al [11], the prognostic index was based on a combination of the number of metastatic sites, sex, serum albumin levels, performance status, and lactate dehydrogenase values.…”

“…Concerning the prognostic factor TNM stage, we found that an advanced stage of disease was strongly correlated with a shorter survival time. Our results for the factor stage were confirmed by many other authors in multivariate analyses [10,[23][24][25][26][27] for patients with advanced, inoperable NSCLC. Reviewing the literature, we found that the prognosis of patients worsened with higher tumor stage.…”

Pretreatment Prognostic Factors for Survival in Non-Small-Cell Lung Cancer: A Multivariate Analysis of 229 Patients

“…1). Our findings support the results of other studies [10,11,23], despite variable clinical groups of patients and differences in index design. In the study published by Shinkai et al [11], the prognostic index was based on a combination of the number of metastatic sites, sex, serum albumin levels, performance status, and lactate dehydrogenase values.…”

“…Concerning the prognostic factor TNM stage, we found that an advanced stage of disease was strongly correlated with a shorter survival time. Our results for the factor stage were confirmed by many other authors in multivariate analyses [10,[23][24][25][26][27] for patients with advanced, inoperable NSCLC. Reviewing the literature, we found that the prognosis of patients worsened with higher tumor stage.…”

Prognostic Factors for Survival in Inoperable Non-Small-Cell Lung Cancer: A Multivariate Regression Analysis of 456 Patients with Radiation Therapy

“…Only when we compared squamous-cell and adenocarcinoma to large-cell carcinoma, there was a slight im provement in median survival for patients with squamous-cell and adenocarcinoma of the lung. Our finding that low or normal LDH levels are of high prog nostic impact for survival is in agreement with many other authors [11,22,24,25] and may help the panel of the next con sensus report in NSCLC to switch LDH from a possible to a definite prognostic factor. LDH is a ubiquitous cellular enzyme and its isoenzyme LDH3 is known to be increased, especially in pulmonary disease.…”

Pretreatment clinical prognostic factors in patients with stage IV non-small cell lung cancer (NSCLC) treated with chemotherapy

“…Liver metastases were found to be an adverse prognosticator in the studies of Lanzotti et al [27], Ewans et al [38], Finkelstein et al [26], and Sorensen et al [32] as well as in the current study. Liver metastases were found to be an adverse prognosticator in the studies of Lanzotti et al [27], Ewans et al [38], Finkelstein et al [26], and Sorensen et al [32] as well as in the current study.…”

“…This was not so in the studies of O'Connell et al [31], Miller et al [25], Sakurai et al [29], Shinkai et al [36], Sculier et al [39], and Hikisch et al [42], which has made any solid recommendation/conclusions impossible. While the presence of bone metastases adversely predicted survival in the studies of O'Connell et al [31] and Finkelstein et al [26], all other studies [25,29,32,39,42] as well as our own have not observed this. While the presence of bone metastases adversely predicted survival in the studies of O'Connell et al [31] and Finkelstein et al [26], all other studies [25,29,32,39,42] as well as our own have not observed this.…”

Pretreatment Prognostic Factors for Survival in Non-Small-Cell Lung Cancer: A Multivariate Analysis of 229 Patients

“…1). Our findings support the results of other studies [10,11,23], despite variable clinical groups of patients and differences in index design. In the study published by Shinkai et al [11], the prognostic index was based on a combination of the number of metastatic sites, sex, serum albumin levels, performance status, and lactate dehydrogenase values.…”

“…Concerning the prognostic factor TNM stage, we found that an advanced stage of disease was strongly correlated with a shorter survival time. Our results for the factor stage were confirmed by many other authors in multivariate analyses [10,[23][24][25][26][27] for patients with advanced, inoperable NSCLC. Reviewing the literature, we found that the prognosis of patients worsened with higher tumor stage.…”

Prognostic Factors for Survival in Inoperable Non-Small-Cell Lung Cancer: A Multivariate Regression Analysis of 456 Patients with Radiation Therapy

“…Only when we compared squamous-cell and adenocarcinoma to large-cell carcinoma, there was a slight im provement in median survival for patients with squamous-cell and adenocarcinoma of the lung. Our finding that low or normal LDH levels are of high prog nostic impact for survival is in agreement with many other authors [11,22,24,25] and may help the panel of the next con sensus report in NSCLC to switch LDH from a possible to a definite prognostic factor. LDH is a ubiquitous cellular enzyme and its isoenzyme LDH3 is known to be increased, especially in pulmonary disease.…”

Pretreatment clinical prognostic factors in patients with stage IV non-small cell lung cancer (NSCLC) treated with chemotherapy

“…Liver metastases were found to be an adverse prognosticator in the studies of Lanzotti et al [27], Ewans et al [38], Finkelstein et al [26], and Sorensen et al [32] as well as in the current study. Liver metastases were found to be an adverse prognosticator in the studies of Lanzotti et al [27], Ewans et al [38], Finkelstein et al [26], and Sorensen et al [32] as well as in the current study.…”

“…This was not so in the studies of O'Connell et al [31], Miller et al [25], Sakurai et al [29], Shinkai et al [36], Sculier et al [39], and Hikisch et al [42], which has made any solid recommendation/conclusions impossible. While the presence of bone metastases adversely predicted survival in the studies of O'Connell et al [31] and Finkelstein et al [26], all other studies [25,29,32,39,42] as well as our own have not observed this. While the presence of bone metastases adversely predicted survival in the studies of O'Connell et al [31] and Finkelstein et al [26], all other studies [25,29,32,39,42] as well as our own have not observed this.…”

Pretreatment Prognostic Factors for Survival in Non-Small-Cell Lung Cancer: A Multivariate Analysis of 229 Patients

“…1). Our findings support the results of other studies [10,11,23], despite variable clinical groups of patients and differences in index design. In the study published by Shinkai et al [11], the prognostic index was based on a combination of the number of metastatic sites, sex, serum albumin levels, performance status, and lactate dehydrogenase values.…”

“…Concerning the prognostic factor TNM stage, we found that an advanced stage of disease was strongly correlated with a shorter survival time. Our results for the factor stage were confirmed by many other authors in multivariate analyses [10,[23][24][25][26][27] for patients with advanced, inoperable NSCLC. Reviewing the literature, we found that the prognosis of patients worsened with higher tumor stage.…”

Prognostic Factors for Survival in Inoperable Non-Small-Cell Lung Cancer: A Multivariate Regression Analysis of 456 Patients with Radiation Therapy

“…Only when we compared squamous-cell and adenocarcinoma to large-cell carcinoma, there was a slight im provement in median survival for patients with squamous-cell and adenocarcinoma of the lung. Our finding that low or normal LDH levels are of high prog nostic impact for survival is in agreement with many other authors [11,22,24,25] and may help the panel of the next con sensus report in NSCLC to switch LDH from a possible to a definite prognostic factor. LDH is a ubiquitous cellular enzyme and its isoenzyme LDH3 is known to be increased, especially in pulmonary disease.…”

Pretreatment clinical prognostic factors in patients with stage IV non-small cell lung cancer (NSCLC) treated with chemotherapy

“…Liver metastases were found to be an adverse prognosticator in the studies of Lanzotti et al [27], Ewans et al [38], Finkelstein et al [26], and Sorensen et al [32] as well as in the current study. Liver metastases were found to be an adverse prognosticator in the studies of Lanzotti et al [27], Ewans et al [38], Finkelstein et al [26], and Sorensen et al [32] as well as in the current study.…”

“…This was not so in the studies of O'Connell et al [31], Miller et al [25], Sakurai et al [29], Shinkai et al [36], Sculier et al [39], and Hikisch et al [42], which has made any solid recommendation/conclusions impossible. While the presence of bone metastases adversely predicted survival in the studies of O'Connell et al [31] and Finkelstein et al [26], all other studies [25,29,32,39,42] as well as our own have not observed this. While the presence of bone metastases adversely predicted survival in the studies of O'Connell et al [31] and Finkelstein et al [26], all other studies [25,29,32,39,42] as well as our own have not observed this.…”