Prognostic factors for tube feeding dependence after curative (chemo-) radiation in head and neck cancer: A systematic review of literature

Wopken, K.; Bijl, H.P.; Langendijk, Johannes A.

doi:10.1016/j.radonc.2017.08.022

Cited by 52 publications

(49 citation statements)

References 151 publications

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“…The median neck SMI was 12 (range [8][9][10][11][12][13][14][15][16][17][18][19][20][21][22], and 61 patients (48%) became prolonged feeding tube-dependent (see Table 1).…”

Section: Resultsmentioning

confidence: 99%

“…First, the extent of tumor and treatment disrupt normal swallowing physiology, and with more extensive tumor and treatment, the risk for developing swallowing problems is increased . Second, poor nutritional status can also contribute to swallowing dysfunction, due to loss of muscle mass and function . As a result of swallowing dysfunction, a substantial proportion (50%‐70%) of patients become feeding tube‐dependent during CRT .…”

Section: Introductionmentioning

confidence: 99%

“…[17][18][19][20][21][22][23][24] Second, poor nutritional status can also contribute to swallowing dysfunction, due to loss of muscle mass and function. [19][20][21][22][23][24] As a result of swallowing dysfunction, a substantial proportion (50%-70%) of patients become feeding tube-dependent during CRT. 23 Due to the decline in swallowing muscle activity, nonuse atrophy of these muscles is inevitable, which is associated with further loss of swallowing muscle mass and function.…”

Section: Introductionmentioning

confidence: 99%

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Sarcopenia, a strong determinant for prolonged feeding tube dependency after chemoradiotherapy for head and neck cancer

et al. 2019

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Background Sarcopenia might be a relevant lead for optimization of the condition of patients with head and neck cancer (HNC) before chemoradiotherapy (CRT) to prevent long‐term functional swallowing impairment, such as feeding tube dependency. Methods Regression analyses were performed to assess the association between skeletal muscle mass index (SMI), as a measure of sarcopenia, and prolonged (>90 days) feeding tube dependency in 128 patients with HNC treated with primary CRT. Results Sixty‐one patients (48%) became prolonged feeding tube‐dependent. Lower SMI increased the risk of prolonged feeding tube dependency in multivariable analysis (risk ratio 1.08; 95% confidence interval 1.02‐1.14, P = .01) adjusted for body mass index, abnormal diet, and socioeconomic status. Conclusions Sarcopenia contributes to the risk of prolonged feeding tube dependency of patients with HNC treated with primary CRT. As sarcopenia might be a modifiable factor prior to treatment, it should be explored as a target for pretreatment patients' condition.

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“…The median neck SMI was 12 (range [8][9][10][11][12][13][14][15][16][17][18][19][20][21][22], and 61 patients (48%) became prolonged feeding tube-dependent (see Table 1).…”

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Sarcopenia, a strong determinant for prolonged feeding tube dependency after chemoradiotherapy for head and neck cancer

et al. 2019

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“…A recent review states that prophylactic PEG tube placement is a risk factor for PEG tube dependency. 5 This statement is based on a single study 8 where PEG tube dependency was higher in patients with prophylactic placement. The decision on prophylactic placement, however, was based on the clinicians' discretion.…”

Section: Peg-related Complicationsmentioning

confidence: 99%

“…2,3 A systematic review describing the impact of prophylactic PEG use on PEG duration and treatment complications as weight loss described conflicting results in various studies. 5 Most of the studies describing cohorts with prophylactic PEG tubes or comparing prophylactic and reactive PEG tube insertion focus on one of the following outcomes: PEG tube dependency, weight loss and renal failure or quality of life. The present study was performed to investigate the frequency of PEG tube dependency and the complication risk after prophylactic PEG tube placement in patients treated with CRT or radiation with cetuximab for HNC.…”

Section: Introductionmentioning

confidence: 99%

PEG tube dependency after prophylactic placement in 209 head and neck cancer patients treated with chemoradiotherapy or radiation with cetuximab

Vrolijk

Zuijdewijn

Slingerland

et al. 2019

Clinical Otolaryngology

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Prevalence of profound laryngeal sensory neuropathy in head and neck cancer survivors with feeding tube‐dependent oropharyngeal dysphagia

et al. 2019

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Background: Laryngopharyngeal sensory neuropathy (LSN) has been observed to be a contributing factor to swallowing dysfunction in head and neck cancer (HNC) survivors.Methods: Retrospective review of 43 tube-dependent HNC survivors was conducted. LSN was assessed with direct palpation of the aryepiglottic fold and by traversing the true vocal folds without eliciting a cough reflex with a flexible laryngoscope. Results: The primary tumor sites were oropharynx (51%), larynx (14%), nasopharynx (4.7%), oral cavity (14%), thyroid (4.7%), unknown primary (9.3%), and esophagus (2.3%). The prevalence of profound LSN was 79.1%. Objective fluoroscopic parameters contributing to swallowing dysfunction were diminished laryngohyoid elevation (100%), pharyngeal weakness (67%), and reduced lateral PES opening (37%). Conclusions:The prevalence of LSN in HNC survivors with feeding tubedependent dysphagia is high (79.1%). The data suggest that LSN, in addition to fibrosis, pharyngoesophageal stenosis, and cranial nerve motor deficits contributes to swallowing dysfunction in these patients. K E Y W O R D Sdysphagia, feeding tube, neuropathy

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Prognostic factors for tube feeding dependence after curative (chemo-) radiation in head and neck cancer: A systematic review of literature

Cited by 52 publications

References 151 publications

Sarcopenia, a strong determinant for prolonged feeding tube dependency after chemoradiotherapy for head and neck cancer

Sarcopenia, a strong determinant for prolonged feeding tube dependency after chemoradiotherapy for head and neck cancer

PEG tube dependency after prophylactic placement in 209 head and neck cancer patients treated with chemoradiotherapy or radiation with cetuximab

Prevalence of profound laryngeal sensory neuropathy in head and neck cancer survivors with feeding tube‐dependent oropharyngeal dysphagia

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