Prognostic factors and outcomes of COVID-19 cases in Ethiopia: multi-center cohort study protocol

Abdella, Saro; Tessema, Masresha; Tasew, Geremew; Defar, Atkure; Deressa, Asefa; Regasa, Feyisa; Teka, Frehiwot; Tigabu, Eyasu; Nigussie, Dereje; Belachew, Tefera; Molla, Million; Deribew, Amare; Abebe, Workeabeba; Yigzaw, Tegbar; Nigatu, Tsinuel Girma; Mitike, Getnet; Haile, Tewodros; Taame, Haftom; Ahmed, Muhammed; Nigatu, Frehiwot; Tolesa, Tola; Wolka, Eskinder; Amogne, Wondwossen; Laillou, Arnaud; Amare, Misker; Fufa, Yaregal; Argaw, Alemayehu; Waganew, Woldesenbet; Azazh, Akilili; Worku, Aschalew; Redae, Berhane; Sultan, Menbeu; Walelegn, Miraf; Tefera, Molla; Yifru, Sisay; Argaw, Rahel; Brehau, Natinael; Teklu, Sisay; Demoz, Getachew; Seman, Yakob; Salasibew, Mihretab; Ejeta, Eshetu; Whiting, Susan J.; Wolday, Dawit; Tollera, Getachew; Abate, Ebba; Duguma, Dereje

doi:10.1186/s12879-021-06652-0

Cited by 2 publications

(1 citation statement)

References 26 publications

(24 reference statements)

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“…Furthermore, it helps to know detailed information about the disease, for example, the pattern of the disease. As a result, health providers can plan and mobilize resources effectively [ 33 , 34 ]. Still, there is no study on this topic in Benishangul Gumuz Reginal State (BGRS) of Ethiopia particularly in the Assosa COVID-19 treatment center.…”

Section: Introductionmentioning

confidence: 99%

Time to recovery and its determinant factors among patients with COVID-19 in Assosa COVID-19 treatment center, Western Ethiopia

Kassie,

Gobena,

Alemu

et al. 2023

Pneumonia

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Background The Novel Coronavirus disease (COVID-19) pandemic has become a global threat. Determining the time to recovery from COVID-19 is intended to assist healthcare professionals in providing better care, and planning logistics. So, the study aimed to identify the factors that affect the time to recovery from COVID-19 for patients treated at Assosa COVID-19 treatment center, Benishangul Gumuz Regional State, Western Ethiopia. Methods A retrospective study design was conducted on 334 randomly selected COVID-19 patients at Assosa COVID-19 treatment center from February 2021 to July 2021. The median survival time, Kaplan–Meier survival estimate, and Log-Rank test were used to describe the data and compare the survival time between groups. The study used the Cox PH model to analyze the time to the first recovery of COVID-19 patients, where hazard ratio, p-value, and 95% CI for hazard ratio were used for testing significance. Schoenfeld and Cox-Snell residuals were used for checking the model assumption. Results The overall incidence rate was 13.79 per 100 (95% CI: 10.04, 18.95) person-days observations. The median time to recovery was 16 days. At the end of the follow-up, 77.2% of the patients had developed an event of recovery, and the rest 22.8% were censored. The mean age of patients was 45.22 years. Severe COVID-19 patients (AHR = 0.7876, 95% CI: 0.7090, 0.8748), presence of symptoms (AHR = 0.2814, 95% CI: 0.1340, 0.5914), comorbidity (AHR = 0.1627, 95% CI: 0.1396, 0.1897), ≥ 90 oxygen saturation (AHR = 3.2370, 95% CI: 2.161, 4.848), and being older age (AHR = 0.9840, 95% CI: 0.971, 0.9973) were found to have statistically significant association with the time to recovery from COVID-19. Conclusion The study concludes that severe COVID-19 patients, male patients, patients having comorbidity, older age, and patients having symptoms as poor prognostic factors of COVID-19 disease and also prolonged recovery time. Therefore, health providers in treatment centers should give strict follow-up and priority to older patients, severe COVID-19 patients, and patients having another co-morbid illness by focusing on respiratory difficulties and underlying pre-existing medical conditions to manage the disease severity and recover quickly.

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Section: Introductionmentioning

confidence: 99%

Time to recovery and its determinant factors among patients with COVID-19 in Assosa COVID-19 treatment center, Western Ethiopia

Kassie,

Gobena,

Alemu

et al. 2023

Pneumonia

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Survival status and predictors of mortality among COVID-19 patients admitted to intensive care units at COVID-19 centers in Addis Ababa, Ethiopia: a retrospective study

Boka

Tadesse

W/Yohannes

et al. 2023

Annals of Medicine &Amp; Surgery

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Introduction: Worldwide, including in Ethiopia, there is an increased risk of coronavirus disease 2019 (COVID-19) disease severity and mortality. This study aimed to assess the survival status and predictors of mortality among COVID-19 patients admitted to the intensive care unit. Methods: This study included 508 COVID-19 patients retrospectively who were under follow-up. The work has been reported in line with the STROCSS (strengthening the reporting of cohort, cross-sectional and case–control studies in surgery) criteria. The data were collected through a systematic sampling from patients’ charts. Kaplan–Meier survival curves and logrank test, and Cox’s regression analyses were conducted to check the difference among categories of covariates and to identify predictors of mortality, respectively. Results: All patient charts were reviewed and the information was recorded. The average age (mean+SD) of these patients was 62.1+13.6 years. Among study participants, 422 deaths occurred and the mortality rate was 64.1 per 1000 person-days. The median survival time was 13 days [interquartile range (IQR): 10–18]. The significant predictors for this survival were: Age>45 years [adjusted hazard ratio (AHR)=4.34, 95% CI: 2.46–7.86], Diabetes mellitus (AHR=1.37, 95% CI: 1.05–1.77), Hypertension (AHR=1.39, 95% CI: 1.09–1.79), Renal disease (AHR=1.86, 95% CI: 1.01–3.43), Hypotension (AHR=1.71, 95% CI: 1.28–2.27), Electrolyte treatment (AHR=0.78, 95% CI: 0.63–0.97). Conclusion: The median survival of COVID-19 patients after their admission was 13 days, and predictors for this time were advanced age, preexisting comorbidities (like diabetes mellitus, hypertension, and renal disease), hypotension, and electrolyte therapy.

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Prognostic factors and outcomes of COVID-19 cases in Ethiopia: multi-center cohort study protocol

Cited by 2 publications

References 26 publications

Time to recovery and its determinant factors among patients with COVID-19 in Assosa COVID-19 treatment center, Western Ethiopia

Time to recovery and its determinant factors among patients with COVID-19 in Assosa COVID-19 treatment center, Western Ethiopia

Survival status and predictors of mortality among COVID-19 patients admitted to intensive care units at COVID-19 centers in Addis Ababa, Ethiopia: a retrospective study

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