Prognostic factors and long-term clinical outcomes for surgical patients with intestinal Behcetʼs disease

Abstract

According to the current study, volcano-shaped ulcers, higher CRP levels, a history of postoperative steroid therapy, and the presence of intestinal perforations detected by pathology were factors of a poor prognosis. Careful follow-up is required in surgical patients with these risk factors, who are at high risk for recurrence and reoperation.

A Case of Intestinal Behçet's Disease Treated with Infliximab Monotherapy Who Successfully Maintained Clinical Remission and Complete Mucosal Healing for Six Years

“…A retrospective analysis of 72 patients with intestinal Behçet's disease who underwent surgery in Korea showed that recurrence after surgical treatment was observed in 58.3% of patients, and reoperations were performed in 30.6% of patients. The cumulative recurrence rates after surgical treatment were 29.2% at 2 years and 47.2% at 5 years (20). Considering these reports, intestinal Behçet's disease, at least in some patients, should be recognized as a progressive disease resulting in severe bowel damage and requiring multiple surgeries.…”

Efficacy of Infliximab in Patients with Intestinal Behçet's Disease Refractory to Conventional Medication

“…Although corticosteroids (CSs) and immunomodulators have shown efficacy in cases of intestinal BD, many patients become refractory to these drugs and some patients are intolerant to particular drugs, such as aminosalicylates, mesalazine, CSs, azathioprine (AZA) and colchicine, that are commonly used to treat BD. Surgery is an option when the condition becomes fulminant; however, BD can recur and a patient may require surgery on more than one occasion (3,4). Therefore, new approaches to treatment with long-term efficacy and good safety profiles are required for better therapeutic outcomes in this disease.…”

Surgery in Inflammatory Bowel Diseases

“…Among the clinical variables studied, previous surgery for perforation or fi stula was the only signifi cant factor associated with postoperative endoscopic recurrence. More recently, it is identifi ed volcano-shaped ulcers, higher CRP level (>4.4 mg/dL), and intestinal perforation on surgical pathology as independent predictors of recurrence [ 92 ]. Patients who received postoperative azathioprine had lower reoperation rates than those that did not.…”