Prognostic Factors and Clinical Outcomes in Extraskeletal Ewing Sarcoma: A Cohort Study

Mathew, Joseph; Arjunan, Ravi; Dasappa, Ashwathappa; Namachivayam, ArunKumar

doi:10.1245/s10434-022-12992-1

Cited by 5 publications

(2 citation statements)

References 28 publications

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“…Like most malignancies, the treatment of laryngeal EWS is dominated by surgical excision, with radiotherapy and chemotherapy performed as auxiliary empirical therapies ( 20 ). Previous studies have shown that patients who undergo radiotherapy after surgery have better prognoses; furthermore, a smaller diameter of the largest tumor correlates with a greater survival rate ( 12 , 21 , 22 ). Moreover, the prognoses of laryngeal EWS are related to the patient’s age and disease stage at the time of diagnosis.…”

Section: Discussionmentioning

confidence: 99%

Fluoro-18-fluorodeoxyglucose positron emission tomography/computed tomography detects Ewing’s sarcoma of the larynx with multiple distant bone metastases: a case report and literature review

Liao

Wang

et al. 2023

Front. Med.

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Ewing sarcomas (EWS) are highly malignant neoplasms of mesenchymal origin that are rare in the head and neck. Only a few laryngeal EWS have been reported in the literature. We report a 47 years-old man who visited our hospital for medical help after 5 months of hoarseness and sore throat. Computed tomography (CT) showed uneven thickening of the epiglottis fold, right vocal cord, and anterior union. In addition, fluoro-18-fluorodeoxyglucose positron emission tomography (18F-FDG PET)/CT has confirmed high activity in the already known laryngeal and nodal lesions, and has revealed otherwise unknown skeletal metastases. We also reviewed the published clinical features, histopathology, and imaging findings of nine patients with laryngeal EWS confirmed by pathology. The main clinical manifestations of laryngeal EWS are rapidly growing lumps, hoarseness, acute respiratory distress, and aphonia. The EWS tumor cells usually express CD99, vimentin, synaptophysin (Syn), and neuron-specific enolase (NSE) but do not express common antigen (LCA), CD20, and chromaffin granin (CgA). Laryngeal EWS’ CT imaging characteristics are mainly homogeneous, well-bounded soft-tissue masses. Our case suggests that EWS should be considered a differential diagnosis of laryngeal cancer, especially when PET/CT reveals distant bone metastasis, which is more likely to indicate EWS.

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Section: Discussionmentioning

confidence: 99%

Fluoro-18-fluorodeoxyglucose positron emission tomography/computed tomography detects Ewing’s sarcoma of the larynx with multiple distant bone metastases: a case report and literature review

Liao

Wang

et al. 2023

Front. Med.

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“…Ewing sarcoma is a highly malignant neuroectodermal small cell tumor most commonly affecting children and adolescents, with primary tumor locations in the femur, long axial bones, and pelvis [1]. Extraskeletal Ewing sarcoma (EES) is a rare tumor that affects a broad age distribution and can develop in various tissues throughout the body, with the presentation depending on the tissue affected [2]. Small bowel tumors are extremely uncommon to begin with, and sarcomas, often relegated to the 'other' category, comprise approximately 10 percent of them [3].…”

Section: Introductionmentioning

confidence: 99%

Unveiling the Unlikely: Extraskeletal Ewing Sarcoma Masquerading as Gastrointestinal Bleeding

Greenfield,

Wilson,

Schulte

et al. 2024

Cureus

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While Ewing sarcoma is traditionally a malignant tumor of bone, it may uncommonly present extraskeletally, leading to an array of puzzling presentations depending on the tissue involved. Here, we describe the case of a 66-year-old man who presented to the primary care office for evaluation of intermittent melena. He ultimately underwent capsule endoscopy and developed a secondary small bowel obstruction, unveiling his neoplasm. The tumor was then resected and managed with surveillance only, and the patient remains without evidence of disease after four years of follow-up.

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Prognostic factors and overall survival in pelvic Ewing's sarcoma and chordoma: A comparative SEER database analysis

Tang,

Li,

Lai

et al. 2024

Heliyon

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Prognostic Factors and Clinical Outcomes in Extraskeletal Ewing Sarcoma: A Cohort Study

Cited by 5 publications

References 28 publications

Fluoro-18-fluorodeoxyglucose positron emission tomography/computed tomography detects Ewing’s sarcoma of the larynx with multiple distant bone metastases: a case report and literature review

Fluoro-18-fluorodeoxyglucose positron emission tomography/computed tomography detects Ewing’s sarcoma of the larynx with multiple distant bone metastases: a case report and literature review

Unveiling the Unlikely: Extraskeletal Ewing Sarcoma Masquerading as Gastrointestinal Bleeding

Prognostic factors and overall survival in pelvic Ewing's sarcoma and chordoma: A comparative SEER database analysis

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