2014
DOI: 10.1158/1078-0432.ccr-13-2830
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Abstract: Purpose: To determine whether the tumor immune infiltrate, as recently evaluated with the Immunoscore methodology, could be a useful prognostic marker in patients with rectal cancers.Experimental design: The influence of the immune infiltrate on patient's outcome was investigated in patients with or without preoperative chemoradiation therapy (pCRT). The density of total (CD3 þ ) and cytotoxic (CD8 þ ) T lymphocytes was evaluated by immunohistochemistry and quantified by a dedicated image analysis software in … Show more

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Cited by 295 publications
(318 citation statements)
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“…1A). These immunological biomarkers include: (1) parameters of broad T cell immunophenotyping, such as the so-called "Immunoscore", [248][249][250] and the abundance of tumor-infiltrating or circulating CD3 C , CD4…”
Section: Ongoing Clinical Trialsmentioning
confidence: 99%
“…1A). These immunological biomarkers include: (1) parameters of broad T cell immunophenotyping, such as the so-called "Immunoscore", [248][249][250] and the abundance of tumor-infiltrating or circulating CD3 C , CD4…”
Section: Ongoing Clinical Trialsmentioning
confidence: 99%
“…The presence of intratumoral T cells is considered a good prognostic factor in colorectal cancer [34][35][36][37][38]. Recent studies indicated that an elevated number of intratumoral T cells, elevated HLA class I expression levels, and STAT1 activation are beneficial prognostic biomarkers for colorectal cancer [39].…”
Section: Il-12 Activates Stat4 In Cd4 + T Cells Subsequently Inducinmentioning
confidence: 99%
“…Actually, we did not look at the different subsets of lymphocytes that can be found in the tumor microenvironment. The so-called tumorinfiltrating lymphocytes (TILs) have a prognostic value in various primary solid cancer types, including CRC (25,26). Schweiger et al nicely showed that tumor infiltrating CD8+ and FoxP3 positive cells were associated with disease free survival and OS after pulmonary metastasectomy in a cohort of patients with CRC lung metastases.…”
Section: P=0003 With Univariate Cox Regression)mentioning
confidence: 99%