Prognostic and clinical significance of histone deacetylase 1 expression in breast cancer: A meta-analysis

Qiao, Weiqiang; Liu, Heyang; Liu, Ruidong; Liu, Qipeng; Zhang, Ting; Guo, Wanying; Li, Peng; Deng, Miao

doi:10.1016/j.cca.2018.05.005

Cited by 16 publications

(9 citation statements)

References 39 publications

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“…No HDAC1 contains 482 amino acids, identified in 1996 by Taunton et al (17). HDAC1 regulates genes involved in cell differentiation and the cell cycle, and participates in the development of various diseases such as viral infectious diseases, degenerative diseases and cancer (18)(19)(20). HDAC1 can mediate site-specific DNA-binding transcriptional repression and a high level of HDAC1 is observed in tumor invasion and metastasis (21).…”

Section: Expression Of Hdac3 Mrna Clinicopathological ---------------mentioning

confidence: 99%

Clinical significance of HDAC1, -2 and -3 expression levels in esophageal squamous cell carcinoma

Yibulayin

et al. 2020

Exp Ther Med

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The present study analyzed the expression of the histone deacetylase (HDAC) 1, 2 and 3 in primary esophageal squamous cell carcinoma (ESCC) samples and how their levels correlate with clinicopathological parameters. ESCC patients (n=88) in the present study had received no previous treatment before undergoing surgical excision. The mRNA expression of HDAC1,-2 and-3 were detected by semi-quantified PCR in ESCC samples and distal normal samples. The relationship of HDAC1,-2 and-3 expression with clinicopathological parameters was analyzed by χ 2 test. The correlation among these HDACs was analyzed by Pearson's correlation test. Compared with distal normal tissues, ESCC samples had higher expression of HDAC1, but not HDAC2 or HDAC3 (P<0.05). The expression of HDACs was different between Kazak and Han ethnicities. The expression of HDAC2 was correlated with invasion depth (P<0.05), but not with sex, age, metastasis, or the degree of tumor differentiation (P>0.05). There was no association between HDAC1 or HDAC3 and clinicopathological parameters (P>0.05). For the Kazak and Han ethnicities, HDAC1 expression was present in male patients, patients with well/moderate differentiated ESCC and T3 and T4 ESCC (P<0.01). HDAC1 in patients aged <60 was associated with ethnicity (P<0.05). HDAC2 expression was different in positive LN metastasis, well/moderate differentiation and T3 and T4 ESCC (P<0.01). HDAC3 expression in male patients, patients with negative LN metastasis and well/moderate differentiation ESCC was associated with ethnicity (P<0.05). Additionally, the expression levels of HDAC1,-2 and-3 did not correlate with each other. Thus, HDAC1 expression may be used as a risk factor for ESCC and HDAC2 levels may be used to predict invasion depth. The expression of HDAC1,-2 and-3 has ethnic differences.

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Section: Expression Of Hdac3 Mrna Clinicopathological ---------------mentioning

confidence: 99%

Clinical significance of HDAC1, -2 and -3 expression levels in esophageal squamous cell carcinoma

Yibulayin

et al. 2020

Exp Ther Med

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“…21,22 HDACs are overexpressed in different tumors types, and HDAC expression levels are closely related to prognosis. [23][24][25] Inhibition of HDACs can induce cell growth arrest and apoptosis in a variety of malignant cells, including breast cancer cells, 26 prostate cancer cells, 27 HCC cells, 28 pancreatic cancer cells, 29 lymphoma cells, 30 and lung cancer cells. 31 Thus, HDACs are considered therapeutic targets for various tumors.…”

Section: Introductionmentioning

confidence: 99%

LukS-PV Inhibits Hepatocellular Carcinoma Progression by Downregulating HDAC2 Expression

Wang

Qiang

et al. 2020

Molecular Therapy - Oncolytics

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Hepatocellular carcinoma (HCC) is a common malignant tumor. LukS-PV is the S component of Panton-Valetine leukocidin (PVL), which is secreted by Staphylococcus aureus. This study investigated the effects of LukS-PV on the proliferation, apoptosis, and cell-cycle progression of HCC cells and the mechanisms of its activity. The HCC cells were treated with different LukS-PV concentrations in vitro. Cell Counting Kit-8 and 5-Ethynyl-2'-deoxyuridine (EdU) assays were used to study cell proliferation. Flow cytometry was used to measure apoptosis and cell-cycle progression. Quantitative reverse transcriptase PCR and western blot assays were used to determine mRNA and protein expression levels. Xenograft experiments were performed to determine the in vivo antitumor effect of LukS-PV. Immunostaining was performed to analyze Ki-67 and HDAC2 (histone deacetylase 2) expression. Our results showed that LukS-PV inhibited cell proliferation and induced apoptosis in a concentration-dependent manner in HCC cell lines. LukS-PV also can induce cell-cycle arrest. Moreover, we discovered that LukS-PV attenuated HDAC2 expression and upregulated PTEN; phosphorylated AKT was also reduced. Further studies demonstrated that LukS-PV treatment significantly reduced tumor growth in nude mice and suppressed Ki-67 and HDAC2 levels. Our data revealed a vital role of LukS-PV in suppressing HCC progression by downregulating HDAC2 and upregulating PTEN.

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“…The correlations between HDAC1 and the prognosis of malignant diseases are not clear since the controversial role of HDAC1 in diverse types of cancer. HDAC1 over-expression was discovered to prolong the OS time in Asian breast cancer patients (Qiao et al, 2018), while it was a risk factor for patients with lung cancer (Cao et al, 2017). Knocking down of HDAC1 has been reported to enhance the sensitivity to cisplatinbased chemotherapy in ovarian cancer (Liu et al, 2018), indicating that HDAC1 is a potential therapeutic target.…”

Section: Discussionmentioning

confidence: 99%

Development and Validation of a Novel Histone Acetylation-Related Gene Signature for Predicting the Prognosis of Ovarian Cancer

Dai

2022

Front. Cell Dev. Biol.

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Histone acetylation is one of the most common epigenetic modifications, which plays an important role in tumorigenesis. However, the prognostic role of histone acetylation-regulators in ovarian cancer (OC) remains little known. We compared the expression levels of 40 histone acetylation-related genes between 379 OC samples and 88 normal ovarian tissues and identified 37 differently expressed genes (DEGs). We further explored the prognostic roles of these DEGs, and 8 genes were found to be correlated with overall survival (p < 0.1). In the training stage, an 8 gene‐based signature was conducted by the least absolute shrinkage and selector operator (LASSO) Cox regression. Patients in the training cohort were divided into two risk subgroups according to the risk score calculated by the 8-gene signature, and a notable difference of OS was found between the two subgroups (p < 0.001). The 8-gene risk model was then verified to have a well predictive role on OS in the external validation cohort. Combined with the clinical characteristics, the risk score was proved to be an independent risk factor for OS. In conclusion, the histone acetylation-based gene signature has a well predictive effect on the prognosis of OC and can potentially be applied for clinical treatments.

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Prognostic and clinical significance of histone deacetylase 1 expression in breast cancer: A meta-analysis

Cited by 16 publications

References 39 publications

Clinical significance of HDAC1, -2 and -3 expression levels in esophageal squamous cell carcinoma

Clinical significance of HDAC1, -2 and -3 expression levels in esophageal squamous cell carcinoma

LukS-PV Inhibits Hepatocellular Carcinoma Progression by Downregulating HDAC2 Expression

Development and Validation of a Novel Histone Acetylation-Related Gene Signature for Predicting the Prognosis of Ovarian Cancer

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