Prognosis of Motor Neuron Disease in Japan

Abstract

The outcome of motor neuron disease (MND) in Japan was analyzed using questionnaires based on 768 cases. There was a significant relationship between duration of disease and age at onset, type of disease, degree of hyperreflexia, and cerebrospinal fluid protein level. The sex of the patients appeared to be related to the mode of progression in MND cases with more than 5 years of survival, although overall survival curves were similar for males and females. Geographic factors had no effect on prognosis.

A follow-up study of 60 cases of chronic spinal muscular atrophy

“…This observation is consistent with those of Muller [12], Brooke [1] and Harding et al [7]. Asymmetric or monomelie localization of symptoms at first diagnosis, as already observed in ALS [I0, 24,19], does not necessarily indicate a better course. The worsening of the ALS score in the two groups according lenght of follow-up (less or more than 10 years) is not statistically different.…”

A follow-up study of 60 cases of chronic spinal muscular atrophy

“…This observation is consistent with those of Muller [12], Brooke [1] and Harding et al [7]. Asymmetric or monomelie localization of symptoms at first diagnosis, as already observed in ALS [I0, 24,19], does not necessarily indicate a better course. The worsening of the ALS score in the two groups according lenght of follow-up (less or more than 10 years) is not statistically different.…”

Survival rate of patients with amyotrophic lateral sclerosis in Wakayama Prefecture, Japan, 1966 to 2005

“…The present results indicated that the mean age at onset of ALS patients in Wakayama Prefecture increased to the same level of other reports. The average age at onset for B group was similar to previous Japanese reports, 54.2 years old in Japan in 1982 [11], 58.2 in Hokkaido between 1980 and 1989 [12], and 58.3 in Niigata University Hospital [13]. In other countries, the mean age at onset was reported as 65 years old in California between 1970 and 1986 [14], 63 years old in Minnesota between 1925 and 1998 [15], and 64.2 years for men and 67.8 years for women between 1995 and 1997 in Ireland [16].…”

Follow-Up Study on Amyotrophic Lateral Sclerosis in Rochester, Minn., 1925 through 1984

“…Survivorship in the present study showed a sharp decline by 3 years with a gradual further decline; this is nearly identical to what others have reported from the United States, Guam, Japan, Finland, and Sweden [1,5,6,14,15,26]. Median survivorship for our patients was 23.8 months, which is consistent with the previous Rochester studies [1,9] and similar to the 25 months reported by Gunnarsson and Palm [15] and the 27.5 months reported by Murros and Fogelholm [14].…”

A follow-up study of 60 cases of chronic spinal muscular atrophy

“…This observation is consistent with those of Muller [12], Brooke [1] and Harding et al [7]. Asymmetric or monomelie localization of symptoms at first diagnosis, as already observed in ALS [I0, 24,19], does not necessarily indicate a better course. The worsening of the ALS score in the two groups according lenght of follow-up (less or more than 10 years) is not statistically different.…”

Survival rate of patients with amyotrophic lateral sclerosis in Wakayama Prefecture, Japan, 1966 to 2005

“…The present results indicated that the mean age at onset of ALS patients in Wakayama Prefecture increased to the same level of other reports. The average age at onset for B group was similar to previous Japanese reports, 54.2 years old in Japan in 1982 [11], 58.2 in Hokkaido between 1980 and 1989 [12], and 58.3 in Niigata University Hospital [13]. In other countries, the mean age at onset was reported as 65 years old in California between 1970 and 1986 [14], 63 years old in Minnesota between 1925 and 1998 [15], and 64.2 years for men and 67.8 years for women between 1995 and 1997 in Ireland [16].…”

Follow-Up Study on Amyotrophic Lateral Sclerosis in Rochester, Minn., 1925 through 1984

“…Survivorship in the present study showed a sharp decline by 3 years with a gradual further decline; this is nearly identical to what others have reported from the United States, Guam, Japan, Finland, and Sweden [1,5,6,14,15,26]. Median survivorship for our patients was 23.8 months, which is consistent with the previous Rochester studies [1,9] and similar to the 25 months reported by Gunnarsson and Palm [15] and the 27.5 months reported by Murros and Fogelholm [14].…”

A follow-up study of 60 cases of chronic spinal muscular atrophy

“…This observation is consistent with those of Muller [12], Brooke [1] and Harding et al [7]. Asymmetric or monomelie localization of symptoms at first diagnosis, as already observed in ALS [I0, 24,19], does not necessarily indicate a better course. The worsening of the ALS score in the two groups according lenght of follow-up (less or more than 10 years) is not statistically different.…”

Survival rate of patients with amyotrophic lateral sclerosis in Wakayama Prefecture, Japan, 1966 to 2005

“…The present results indicated that the mean age at onset of ALS patients in Wakayama Prefecture increased to the same level of other reports. The average age at onset for B group was similar to previous Japanese reports, 54.2 years old in Japan in 1982 [11], 58.2 in Hokkaido between 1980 and 1989 [12], and 58.3 in Niigata University Hospital [13]. In other countries, the mean age at onset was reported as 65 years old in California between 1970 and 1986 [14], 63 years old in Minnesota between 1925 and 1998 [15], and 64.2 years for men and 67.8 years for women between 1995 and 1997 in Ireland [16].…”

Follow-Up Study on Amyotrophic Lateral Sclerosis in Rochester, Minn., 1925 through 1984

“…Survivorship in the present study showed a sharp decline by 3 years with a gradual further decline; this is nearly identical to what others have reported from the United States, Guam, Japan, Finland, and Sweden [1,5,6,14,15,26]. Median survivorship for our patients was 23.8 months, which is consistent with the previous Rochester studies [1,9] and similar to the 25 months reported by Gunnarsson and Palm [15] and the 27.5 months reported by Murros and Fogelholm [14].…”