Progesterone is neuroprotective after transient middle cerebral artery occlusion in male rats

Jiang, Ning; Chopp, Michael; Stein, Donald G.; Feit, Howard

doi:10.1016/0006-8993(96)00605-1

Cited by 222 publications

(134 citation statements)

References 59 publications

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“…Altogether, IAD were available for 689 animals. IAD were not shared for six studies in spite of repeated contact with authors; 6,7,12,13,28,29 nevertheless, data from these studies were included in analyses based on summary data. Five studies were excluded, mostly because they did not have data on total lesion volume or vital status, e.g., one study only had data on blood volume collected.…”

Section: Study Flowmentioning

confidence: 99%

“…[4][5][6][7][8][9][10][11][12][13][14] Progesterone has already been shown to be safe and effective for several clinical applications, e.g., hormone replacement therapy, and a variety of preparations are available for different modes of administration. 15 Furthermore, no severe adverse effects have been reported even when progesterone was used at high dose.…”

Section: Introductionmentioning

confidence: 99%

“…Studies assessing the safety and efficacy of progesterone in preclinical models of stroke [4][5][6][7][8][9]13,[20][21][22] have previously been integrated in a systematic review and meta-analysis based on published summary ('group') data. 14 However, this systematic review suggested that key questions remained to be answered, including demonstrating efficacy as a function of sex and age, and evaluating the dose and timing of progesterone administration.…”

Section: Introductionmentioning

confidence: 99%

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Progesterone Treatment for Experimental Stroke: An Individual Animal Meta-Analysis

Wong

Renton

Gibson

et al. 2013

J Cereb Blood Flow Metab

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Preclinical studies suggest progesterone is neuroprotective after cerebral ischemia. The gold standard for assessing intervention effects across studies within and between subgroups is to use meta-analysis based on individual animal data (IAD). Preclinical studies of progesterone in experimental stroke were identified from searches of electronic databases and reference lists. Corresponding authors of papers of interest were contacted to obtain IAD and, if unavailable, summary data were obtained from the publication. Data are given as standardized mean differences (SMDs, continuous data) or odds ratios (binary data), with 95% confidence intervals (95% CIs). In an unadjusted analysis of IAD and summary data, progesterone reduced standardized lesion volume (SMD À 0.766, 95% CI À 1.173 to À 0.358, Po0.001). Publication bias was apparent on visual inspection of a Begg's funnel plot on lesion volume and statistically using Egger's test (P ¼ 0.001). Using individual animal data alone, progesterone was associated with an increase in death in adjusted analysis (odds ratio 2.64, 95% CI 1.17 to 5.97, P ¼ 0.020). Although progesterone significantly reduced lesion volume, it also appeared to increase the incidence of death after experimental stroke, particularly in young ovariectomized female animals. Experimental studies must report the effect of interactions on death and on modifiers, such as age and sex.

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Section: Study Flowmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Progesterone Treatment for Experimental Stroke: An Individual Animal Meta-Analysis

Wong

Renton

Gibson

et al. 2013

J Cereb Blood Flow Metab

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“…The administration of progesterone before 2 hours of ischemia and after 48 hours of reperfusion was responsible for a smaller weight loss 24 . The administration of lidocaine before ischemia followed by 7 days of reperfusion caused a lower weight loss on treated animals than in controls 25 .…”

Section: Discussionmentioning

confidence: 95%

“…Variations in body weight have been used in recent studies as a parameter to evaluate transitory focal cerebral ischemia 24,25 . The administration of progesterone before 2 hours of ischemia and after 48 hours of reperfusion was responsible for a smaller weight loss 24 .…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the neuroprotective effect of ketoprofen on rats submitted to permanent focal brain ischemia

Silva

Colli

Coimbra

et al. 2007

Arq. Neuro-Psiquiatr.

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-Objective: To study the neurobehavioral, biochemical and histopathological consequences of permanent focal brain ischemia, and the putative neuroprotective action of ketoprofen. Method: Onehundred-and-three Wistar rats divided into groups A and B were respectively submitted to 48 hours and 15 days of ischemia. Each group was divided into 4 subgroups: ischemic not treated, ischemic treated, sham not treated, and sham treated. Ischemic animals had the left middle cerebral artery coagulated. Ketoprofen was administered to treated subgroups 15 minutes before arterial coagulation (manipulation in the sham group). Results: Exploratory activity and defecation were reduced in all ischemic animals in the first postoperative days and constant histopathological changes were observed in each group. The total brain glutamate levels were higher in treated animals 48 hours after surgery. Conclusion: No clear parallelism among behavioral, biochemical and histopathological findings was observed. Ketoprofen demonstrated no neuroprotective effect on the behavioral or histopathological aspects of focal permanent brain ischemia.KEY WORDS: focal brain ischemia, rat, open field, glutamate, histopathology, neuroprotection, ketoprofen. Avaliação do efeito neuroprotetor do cetoprofeno em ratos submetidos à isquemia cerebral focal permanenteRESUMO -Objetivo: Estudar as conseqüências comportamentais, bioquímicas e histopatológicas da isquemia cerebral focal permanente e o possível efeito neuroprotetor do cetoprofeno. Método: Foram utilizados 103 ratos Wistar, divididos em grupos A e B, submetidos, respectivamente, a 48 horas e a 15 dias de isquemia. Cada grupo foi dividido em 4 subgrupos: isquêmico não tratado; isquêmico tratado; sham não tratado; sham tratado. Nos animais isquêmicos foi coagulada a artéria cerebral média esquerda. Os subgrupos tratados receberam cetoprofeno 15 minutos antes da oclusão ou manipulação arterial. Resultados: Os animais isquêmicos reduziram a atividade exploratória e as evacuações nos primeiros dias pós-operatórios e mostraram alterações histopatológicas constantes em cada grupo. As concentrações do glutamato total 48 horas após a cirurgia foram maiores nos animais tratados. Conclusão: Não houve um paralelismo entre os achados comportamentais, bioquímicos e histopatológicos. O cetoprofeno não apresentou efeito protetor contra isquemia cerebral focal permanente, nos aspectos comportamentais e histopatológicos.

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Unsupervised segmentation of multiparameter MRI in experimental cerebral ischemia with comparison to T2, diffusion, and ADC MRI parameters and histopathological validation

Jacobs

Knight

Soltanian-Zadeh

et al. 2000

J. Magn. Reson. Imaging

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This study presents histological validation of an objective (unsupervised) computer segmentation algorithm, the iterative self‐organizing data analysis technique (ISODATA), for analysis of multiparameter magnetic resonance imaging (MRI) data in experimental focal cerebral ischemia. T2‐, T1‐, and diffusion (DWI) weighted coronal images were acquired from 4 to 168 hours after stroke on separate groups of animals. Animals were killed immediately after MRI for histological analysis. MR images were coregistered/warped to histology. MRI lesion areas were defined using DWI, apparent diffusion coefficient (ADC) maps, T2‐weighted images, and ISODATA. The last techniques clearly discriminated between ischemia‐altered and morphologically intact tissue. ISODATA areas were congruent and significantly correlated (r = 0.99, P < 0.05) with histologically defined lesions. In contrast, DWI, ADC, and T2 lesion areas showed no significant correlation with histologically evaluated lesions until subacute time points. These data indicate that multiparameter ISODATA methodology can accurately detect and identify ischemic cell damage early and late after ischemia, with ISODATA outperforming ADC, DWI, and T2‐weighted images in identification of ischemic lesions from 4 to 168 hours after stroke. J. Magn. Reson. Imaging 2000;11:425–437. © 2000 Wiley‐Liss, Inc.

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Progesterone is neuroprotective after transient middle cerebral artery occlusion in male rats

Cited by 222 publications

References 59 publications

Progesterone Treatment for Experimental Stroke: An Individual Animal Meta-Analysis

Progesterone Treatment for Experimental Stroke: An Individual Animal Meta-Analysis

Evaluation of the neuroprotective effect of ketoprofen on rats submitted to permanent focal brain ischemia

Unsupervised segmentation of multiparameter MRI in experimental cerebral ischemia with comparison to T2, diffusion, and ADC MRI parameters and histopathological validation

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