Profuse Diarrhea after Misoprostol Use in a Patient with a History of Crohn's Disease

Johnson, Julie S.; Karboski, James A.; Williams, Glenys O.

doi:10.1177/106002809202600910

Cited by 5 publications

(1 citation statement)

References 8 publications

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“…Protected mucosa against increased colonic permeability; no effects on humans, rats, and mice granulocyte infiltration [146][147][148][149][150][151][152][153] ; inhibited human colonic mast cells 154 ; increased hydroxyproline concentration and elevated collagen levels during healing of colonic anastomoses 155 ; failed to prevent severe colitis of NSAID-treated patient 156 ; not effective in ameliorating bisacodyl-induced colitis 157 ; exacerbated Crohn' s disease, leading to diarrhea in some patients. [158][159][160] No effect on residual volume or contractility. 161…”

Section: Colitis and Crohn' S Diseasementioning

confidence: 98%

Misoprostol Therapeutics Revisited

2001

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Misoprostol, a prostaglandin E1 analog, is a racemate of four stereoisomers. On administration it rapidly de-esterifies to its active form, misoprostolic acid. Misoprostolic acid is 85% albumin bound and has a half-life of approximately 30 minutes. It is excreted in urine as inactive metabolites. No significant drug interactions have been reported. Besides its gastrointestinal protective and uterotonic activities, misoprostol regulates various immunologic cascades. It inhibits platelet-activating factor and leukocyte adherence, and modulates adhesion molecule expression. It protects against gut irradiation injury, experimental gastric cancer, enteropathy, and constipation. It improves nutrient absorption in cystic fibrosis. Misoprostol has utility in acetaminophen and ethanol hepatotoxicity, hepatitis, and fibrosis. It is effective in asthmatics and aspirin-sensitive asthmatic and allergic patients. It lowers cholesterol and severity of peripheral vascular diseases, prolongs survival of cardiac and kidney transplantation, synergizes cyclosporine, and protects against cyclosporine-induced renal damage. It works against drug-induced renal damage, interstitial cystitis, lupus nephritis, and hepatorenal syndrome. It is useful in periodontal disease and dental repair. Misoprostol enhances glycosoaminoglycan synthesis in cartilage after injury. It prevents ultraviolet-induced cataracts and reduces intraocular pressure in glaucoma and ocular hypertension. It synergizes antiinflammatory and analgesic effects of diclofenac or colchicine and has been administered to treat trigeminal neuralgic pain. It reduces chemotherapy-induced hair loss and recovery time from burn injury, and is effective in treating sepsis, multiple sclerosis, and pancreatitis.

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