Profiling of kidney involvement in systemic lupus erythematosus by deep learning using the National Database of Designated Incurable Diseases of Japan

Kimura, Tomonori; Ikeuchi, Hidekazu; Yoshino, Mitsuaki; Sakate, Ryuichi; Maruyama, Shoichi; Narita, Ichiei; Hiromura, Keiju

doi:10.1007/s10157-023-02337-x

Cited by 5 publications

(1 citation statement)

References 21 publications

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“…This cross-sectional study used data from clinical personal records, a nationwide administrative database of public expenditure for refractory diseases (so-called the “National Database of Designated Incurable Diseases of Japan”) including primary MPGN, throughout Japan, maintained by the Japanese Ministry of Health, Labour, and Welfare [ 18 ]. The records prospectively and annually collected demographic data (age, sex), chronic kidney disease (CKD) classification based on glomerular filtration rate and albuminuria, medication use (presently used and maximum dosage of present treatment within 6 months), and therapeutic responses (steroid-resistant [never achieved remission]).…”

Section: Methodsmentioning

confidence: 99%

Demographics and treatment of patients with primary membranoproliferative glomerulonephritis in Japan using a national registry of clinical personal records

et al. 2023

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Background Membranoproliferative glomerulonephritis (MPGN) is a rare glomerular injury that causes nephrotic syndrome and end-stage kidney disease. The nationwide demographics and treatment of Japanese patients with primary MPGN have not yet been reported. Methods We collected clinical personal records of patients with primary MPGN between 2015 and 2018 from the national registry organized by the Japanese Ministry of Health, Labour, and Welfare and investigated the characteristics of primary MPGN throughout Japan. Results Of 258 patients with primary MPGN, 199 and 59 showed nephrotic and non-nephrotic syndrome, respectively. The median age at onset was higher in patients with nephrotic syndrome than in those with non-nephrotic syndrome (45 [24–63] vs. 35 [14–53] years, respectively; P = 0.010). The use of oral prednisolone was significantly higher in patients with nephrotic syndrome than in those with non-nephrotic syndrome (73.9% vs. 59.3%, respectively; P = 0.032). When patients were divided into three age groups: adolescent and young adult group (≤ 39 years; n = 80), middle adult group (40–64 years; n = 111), and older adult group (≥ 65 years; n = 67), the use of oral prednisolone, cyclosporine, and mizoribine was significantly higher in the adolescent and young adult group than in the middle adult group. The mean dosage of oral prednisolone and mizoribine showed no differences among the three age groups. Conclusion The national registry of clinical personal records of primary MPGN could provide an informative insight into the characteristics, clinical features, and treatment approaches for patients with primary MPGN in Japan.

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Section: Methodsmentioning

confidence: 99%

Demographics and treatment of patients with primary membranoproliferative glomerulonephritis in Japan using a national registry of clinical personal records

et al. 2023

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Machine learning application in autoimmune diseases: State of art and future prospectives

Danieli,

Brunetto,

Gammeri

et al. 2024

Autoimmunity Reviews

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Demographics and treatment of patients with primary nephrotic syndrome in Japan using a national registry of clinical personal records

Nakagawa,

Kimura,

Sakate

et al. 2023

Sci Rep

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The nationwide clinical features of Japanese patients with primary nephrotic syndrome (NS), including minimal change disease (MCD), focal segmental glomerulosclerosis (FSGS), or membranous nephropathy (MN), have not yet been reported. We collected the clinical personal records of patients with primary NS between 2015 and 2018 from the national registry organized by the Japanese Ministry of Health, Labour, and Welfare. Overall, the demographics, chronic kidney disease classification based on glomerular filtration rate and albuminuria, and treatment of 6036 patients were collected: 3394 (56.2%) with MCD, 677 (11.2%) with FSGS, 1455 (24.1%) with MN, and 510 (8.5%) with others. MN patients were older than MCD and FSGS patients (67 vs. 42 and 47 years, respectively). Steroid-dependent NS or frequently relapsing NS was found in 70.2%, 40.5%, and 24.6%, whereas steroid-resistant NS was found in 6.4%, 36.0%, and 37.9% of patients in the MCD, FSGS, and MN, respectively. The present oral prednisolone use (mean dose, mg/day) was 87.2% (21.2), 80.9% (20.0), and 77.5% (18.8) of patients in the MCD, FSGS, and MN, respectively. The national registry of clinical personal records of primary NS could provide an informative insight into the characteristics, clinical features, and treatment approaches for patients with primary NS in Japan.

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Profiling of kidney involvement in systemic lupus erythematosus by deep learning using the National Database of Designated Incurable Diseases of Japan

Cited by 5 publications

References 21 publications

Demographics and treatment of patients with primary membranoproliferative glomerulonephritis in Japan using a national registry of clinical personal records

Demographics and treatment of patients with primary membranoproliferative glomerulonephritis in Japan using a national registry of clinical personal records

Machine learning application in autoimmune diseases: State of art and future prospectives

Demographics and treatment of patients with primary nephrotic syndrome in Japan using a national registry of clinical personal records

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