Profiles of bacteria/phage-comediated ARGs in pig farm wastewater treatment plants in China: Association with mobile genetic elements, bacterial communities and environmental factors

Yang, Yiwen; Xing, Si-Cheng; Chen, Yingxi; Wu, Ruizhu; Wu, Yinbao; Wang, Yan; Mi, Jiandui; Liao, Xindi

doi:10.1016/j.jhazmat.2020.124149

Cited by 53 publications

(27 citation statements)

References 46 publications

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“…Heavy metals could exert pressure on ARGs, thereby promoting the transfer of ARGs ( He et al, 2020 ). Another study found that the concentration of Cu and Zn in soil was significantly positively correlated with the transduction of pARGs ( Yang et al, 2021 ). Organic matter and heavy metals (Zn, Cr, and Cu) had a greater effect on pARGs than others factors, such as Hg, As, available phosphorus, available potassium, and total nitrogen ( Hu et al, 2022 ).…”

Section: The Contribution Of Phages In the Horizontal Transfer Of Argsmentioning

confidence: 99%

“…Organic matter and heavy metals (Zn, Cr, and Cu) had a greater effect on pARGs than others factors, such as Hg, As, available phosphorus, available potassium, and total nitrogen ( Hu et al, 2022 ). The concentrations of NH 4 -N and total phosphorus are positively correlated with two types of pARGs conferring resistant to tetracyclines and macrolide-lincosamide-streptogramin B ( Yang et al, 2021 ). Random forest modeling and partial least squares path modeling results indicated that pH is a key factor affecting the occurrence of pARGs during the fermentation process ( Xu et al, 2022 ).…”

Section: The Contribution Of Phages In the Horizontal Transfer Of Argsmentioning

confidence: 99%

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Bacteriophages: Underestimated vehicles of antibiotic resistance genes in the soil

et al. 2022

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Bacteriophages (phages), the most abundant biological entities on Earth, have a significant effect on the composition and dynamics of microbial communities, biogeochemical cycles of global ecosystems, and bacterial evolution. A variety of antibiotic resistance genes (ARGs) have been identified in phage genomes in different soil samples. Phages can mediate the transfer of ARGs between bacteria via transduction. Recent studies have suggested that anthropogenic activities promote phage-mediated horizontal gene transfer events. Therefore, the role of phages in the dissemination of ARGs, which are a potential threat to human health, may be underestimated. However, the contribution of phages to the transfer of ARGs is still poorly understood. Considering the growing and wide concerns of antibiotic resistance, phages should be considered a research focus in the mobile resistome. This review aimed to provide an overview of phages as vehicles of ARGs in soil. Here, we summarized the current knowledge on the diversity and abundance of ARGs in soilborne phages and analyzed the contribution of phages to the horizontal transfer of ARGs. Finally, research deficiencies and future perspectives were discussed. This study provides a reference for preventing and controlling ARG pollution in agricultural systems.

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Section: The Contribution Of Phages In the Horizontal Transfer Of Argsmentioning

confidence: 99%

Section: The Contribution Of Phages In the Horizontal Transfer Of Argsmentioning

confidence: 99%

Bacteriophages: Underestimated vehicles of antibiotic resistance genes in the soil

et al. 2022

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“…e Market Failure Model holds that some obstacles in the real market make it difficult to allocate resources only by the price mechanism to achieve the Pareto Optimum, and there is a certain loss of efficiency [12]. erefore, the method of resource allocation in the market is completely generated by the structure of market competition, and also under the influence of external obstacles such as monopoly, information asymmetry, and public goods, the price mechanism will be limited.…”

Section: Environmental Regulation and Productionmentioning

confidence: 99%

“…e combination of the two can make the unnecessary information forgotten. Equation (12) illustrates the process of adding new information:…”

Section: Prediction Model Of Pig Price and Yield Based On Lstmmentioning

confidence: 99%

Production Efficiency Prediction of Pig Breeding Industry by Optimized LSTM Computer Algorithm under Environmental Regulation

Jia

Zhao-hui

et al. 2021

Scientific Programming

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The study aims to improve the economic income of pig breeding industry under environmental regulation and control the environmental pollution caused by pig breeding. Long short-term memory (LSTM) neural network combined with environmental regulation is proposed to forecast the price of live pigs, to reduce the cost of environmental pollution control and improve the production efficiency of pig breeding. Primarily, analyses are made on the industrial structure and pollution of pigs in China, and studies are carried out on the inevitability of large-scale and intensive pig breeding. Then, pig breeding and environmental pollution are coordinated under the environmental regulation. From the perspective of green total factor productivity, calculation is made on the profit of pig breeding and the cost of environmental pollution control. Next, the LSTM neural network is used to predict the price of live pigs, thus effectively controlling the scale of pig breeding and making timely decisions that conform to market rules. The results show that with the increase of feed and land prices, the advantages of large-scale pig breeding gradually become prominent, which leads to the small- and medium-sized scale farmers withdrawing from the market. Compared with other similar models, the designed model can better simulate the future trend of hog price, of which the prediction accuracy is over 80%. When combined with environmental regulations, the prediction accuracy of the model for different data sets reaches 83%, so the designed model can better predict the changing trend of the price of live pigs, thus improving the production efficiency of large-scale pig farmers.

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“…Environments characterized by high levels of fecal matter such as sewage, animal slurry, sludge, and effluent of wastewater treatment plants are hotspots of antibiotic resistant bacteria and phages harboring ARGs, forming an ideal environment for horizontal gene transfer to occur ( Calero-Cáceres et al, 2014 ; Quirós et al, 2014 ; Ross and Topp, 2015 ; Calero-Cáceres and Muniesa, 2016 ; Guo et al, 2017 ; Yang et al, 2021 ; Zieliński et al, 2021 ). It has been shown that transfection and transduction of ARGs from environmental phages conferred resistance to the recipient bacteria ( Battaglioli et al, 2011 ; Colomer-Lluch et al, 2011 ; Gunathilaka et al, 2017 ; Wang et al, 2018b ; Yang et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Bacterial and Bacteriophage Antibiotic Resistance in Marine Bathing Waters in Relation to Rivers and Urban Streams

et al. 2021

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Fecal pollution of surface water may introduce bacteria and bacteriophages harboring antibiotic resistance genes (ARGs) into the aquatic environment. Watercourses discharging into the marine environment, especially close to designated bathing waters, may expose recreational users to fecal pollution and therefore may increase the likelihood that they will be exposed to ARGs. This study compares the bacterial and bacteriophage ARG profiles of two rivers (River Tolka and Liffey) and two small urban streams (Elm Park and Trimleston Streams) that discharge close to two marine bathing waters in Dublin Bay. Despite the potential differences in pollution pressures experienced by these waterways, microbial source tracking analysis showed that the main source of pollution in both rivers and streams in the urban environment is human contamination. All ARGs included in this study, blaTEM, blaSHV, qnrS, and sul1, were present in all four waterways in both the bacterial and bacteriophage fractions, displaying a similar ARG profile. We show that nearshore marine bathing waters are strongly influenced by urban rivers and streams discharging into these, since they shared a similar ARG profile. In comparison to rivers and streams, the levels of bacterial ARGs were significantly reduced in the marine environment. In contrast, the bacteriophage ARG levels in freshwater and the marine were not significantly different. Nearshore marine bathing waters could therefore be a potential reservoir of bacteriophages carrying ARGs. In addition to being considered potential additional fecal indicators organism, bacteriophages may also be viewed as indicators of the spread of antimicrobial resistance.

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Profiles of bacteria/phage-comediated ARGs in pig farm wastewater treatment plants in China: Association with mobile genetic elements, bacterial communities and environmental factors

Cited by 53 publications

References 46 publications

Bacteriophages: Underestimated vehicles of antibiotic resistance genes in the soil

Bacteriophages: Underestimated vehicles of antibiotic resistance genes in the soil

Production Efficiency Prediction of Pig Breeding Industry by Optimized LSTM Computer Algorithm under Environmental Regulation

Bacterial and Bacteriophage Antibiotic Resistance in Marine Bathing Waters in Relation to Rivers and Urban Streams

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