Profiles and neuroprotective effects of<i>Lycium ruthenicum</i>polyphenols against oxidative stress‐induced cytotoxicity in PC12 cells

Gao, Hua; Yuan, Xiao; Wang, Zhisheng; Gao, Qing‐Han; Yang, Jianjun

doi:10.1111/jfbc.13112

Cited by 24 publications

(18 citation statements)

References 44 publications

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“…Yapılan bu çalışmada kaspaz 3 immunpozitifliğinin kontrol ve sadece Rut uygulanan grupta değişmediği, Kolistin ve Kolistin + Rut 50 uygulanan grupta önemli derecede arttığı, kolisitnle birlikte Rut 100 uygulaması sonrası ise bu immunpozitifliğin azaldığı gözlemlenmiştir. Rut uygulamasının kaspaz 3 seviyesini azalttığı ve apoptoz aktivitesini düşürdüğü önceki çalışmalarda rapor edilmiştir [42,[45][46][47][48][49]. Dolayısıyla bu çalışmadan elde edilen veriler önceki çalışmalarla uyumlu olarak bulunmuştur.…”

Section: Discussionunclassified

Rutinin Ratlarda Kolistin Kaynaklı Testis Hasarında Oksidatif DNA Hasarı, NF-κB Aracılı Enflamasyon ve Apoptoz Üzerindeki Koruyucu Etkileri

Çomaklı

İleritürk

Kirman

2020

Türk Doğa Ve Fen Dergisi

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Öz: Kolistin, gram-negatif bakterilerin neden olduğu enfeksiyonlarda tedavi amacıyla son seçenek olarak kullanılmaktadır. Literatürde kolistinin neden olduğu testis toksisitesi bildirilmiş olmasına rağmen mekanizmasına ilişkin çok az veri bulunmaktadır. Yapılan bu çalışmanın amacı kolistin uygulamasının neden olduğu testis toksisitesinde rutinin (Rut) koruyucu etkilerinin araştırılmasıdır. Bu amaç için 5 adet deneysel grup oluşturuldu; Kontrol, Rut (100 mg kg gün -1 ), Kolistin (15 mg kg gün -1 ), Kolistin + Rut (50 mg kg gün -1 ), Kolistin + Rut (100 mg kg gün -1 ). Uygulama sonrasında ratların testis dokularında malondialdehit (MDA) ve redükte glutatyon (GSH) seviyeleri tespit edildi. Aynı zamanda testis dokularının histopatolojik incelemesi yapıldı ve 8-hidroksi-2'deoksiguanozin (8-OHdG), nükleer faktörü kappa B (NF-κB) ve kaspaz 3 aktiviteleri immunohistokimya ile belirlendi. Sonuçlara bakıldığında kolistin uygulamasının rat testis dokularında MDA düzeyini arttırdığı, GSH düzeyini ise azalttığı tespit edilmiştir. Farklı dozlarda Rut uygulaması sonrası ise MDA düzeyinde azalma, GSH düzeyinde ise artış gözlendi. Kolistinin testis dokularında neden olduğu hasar sonucu 8-OHdG, NF-κB ve kaspaz 3 immunpozitifliklerinin arttığı, özellikle Rut (100 mg kg gün -1 ) uygulamasından sonra bu proteinlerin aktivite düzeylerinin azaldığı belirlendi. Sonuç olarak kolistinin rat testislerinde oksidatif hasar, enflamasyon, DNA hasarı ve apoptoza neden olduğu, Rut uygulamasının kolistin kaynaklı testis hasarında koruyucu etki gösterdiği belirlendi.

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Section: Discussionunclassified

Rutinin Ratlarda Kolistin Kaynaklı Testis Hasarında Oksidatif DNA Hasarı, NF-κB Aracılı Enflamasyon ve Apoptoz Üzerindeki Koruyucu Etkileri

Çomaklı

İleritürk

Kirman

2020

Türk Doğa Ve Fen Dergisi

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“…In glutamate-induced PC-12 cells, Lycium barbarum extract markedly increases cell viability and decreases the release of LDH, Ca 2+ overload, ROS generation, and cell apoptosis [379]. In addition, Lycium fruit polyphenols also inhibit the level of intracellular ROS and decrease the expression of caspase-3/-8/-9 in H 2 O 2 -induced PC-12 cells [380]. Furthermore, Lycium barbarum extract significantly attenuates the intracellular ROS accumulation and MMP loss and increases the total levels of GSH in MPP(+)-induced PC-12 cells [381].…”

Section: Litchi Chinensismentioning

confidence: 98%

Dietary Plant Polyphenols as the Potential Drugs in Neurodegenerative Diseases: Current Evidence, Advances, and Opportunities

Guo

Zhang

et al. 2022

Oxidative Medicine and Cellular Longevity

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Neurodegenerative diseases, including Alzheimer’s disease (AD), Parkinson’s disease (PD), and Huntington’s disease (HD), are characterized by the progressive degeneration of neurons. Although the etiology and pathogenesis of neurodegenerative diseases have been studied intensively, the mechanism is still in its infancy. In general, most neurodegenerative diseases share common molecular mechanisms, and multiple risks interact and promote the pathologic process of neurogenerative diseases. At present, most of the approved drugs only alleviate the clinical symptoms but fail to cure neurodegenerative diseases. Numerous studies indicate that dietary plant polyphenols are safe and exhibit potent neuroprotective effects in various neurodegenerative diseases. However, low bioavailability is the biggest obstacle for polyphenol that largely limits its adoption from evidence into clinical practice. In this review, we summarized the widely recognized mechanisms associated with neurodegenerative diseases, such as misfolded proteins, mitochondrial dysfunction, oxidative damage, and neuroinflammatory responses. In addition, we summarized the research advances about the neuroprotective effect of the most widely reported dietary plant polyphenols. Moreover, we discussed the current clinical study and application of polyphenols and the factors that result in low bioavailability, such as poor stability and low permeability across the blood-brain barrier (BBB). In the future, the improvement of absorption and stability, modification of structure and formulation, and the combination therapy will provide more opportunities from the laboratory into the clinic for polyphenols. Lastly, we hope that the present review will encourage further researches on natural dietary polyphenols in the treatment of neurodegenerative diseases.

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“…The brain targeting of quercetin-loaded exosomes enhanced its bioavailability in Alzheimer's disease (AD) and further relieved the symptoms of AD via inhibition of biochemical pathways such as cyclin-dependent kinase 5 (CDK5)-mediated phosphorylation of phosphoprotein Tau and decrease of the formation of insoluble neurofibrillary tangles (NFTs) [116]. Malik et al [117] and Gao et al [118] exploited extracts Lactuca sativa L. and Lycium ruthenicum Murr. extracts rich in quercetin content, and proved their neuroprotective potential.…”

Section: Quercetin As a Neuroprotective Agentmentioning

confidence: 99%

Quercetin: A Bioactive Compound Imparting Cardiovascular and Neuroprotective Benefits: Scope for Exploring Fresh Produce, Their Wastes, and By-Products

Bhat

2021

Biology

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Quercetin, a bioactive secondary metabolite, holds incredible importance in terms of bioactivities, which has been proved by in vivo and in vitro studies. The treatment of cardiovascular and neurological diseases by quercetin has been extensively investigated over the past decade. Quercetin is present naturally in appreciable amounts in fresh produce (fruits and vegetables). However, today, corresponding to the growing population and global demand for fresh fruits and vegetables, a paradigm shift and focus is laid towards exploring industrial food wastes and/or byproducts as a new resource to obtain bioactive compounds such as quercetin. Based on the available research reports over the last decade, quercetin has been suggested as a reliable therapeutic candidate for either treating or alleviating health issues, mainly those of cardiovascular and neurological diseases. In the present review, we have summarized some of the critical findings and hypotheses of quercetin from the available databases foreseeing its future use as a potential therapeutic agent to treat cardiovascular and neurological diseases. It is anticipated that this review will be a potential reference material for future research activities to be undertaken on quercetin obtained from fresh produce as well as their respective processing wastes/byproducts that rely on the circular concept.

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Profiles and neuroprotective effects ofLycium ruthenicumpolyphenols against oxidative stress‐induced cytotoxicity in PC12 cells

Cited by 24 publications

References 44 publications

Rutinin Ratlarda Kolistin Kaynaklı Testis Hasarında Oksidatif DNA Hasarı, NF-κB Aracılı Enflamasyon ve Apoptoz Üzerindeki Koruyucu Etkileri

Rutinin Ratlarda Kolistin Kaynaklı Testis Hasarında Oksidatif DNA Hasarı, NF-κB Aracılı Enflamasyon ve Apoptoz Üzerindeki Koruyucu Etkileri

Dietary Plant Polyphenols as the Potential Drugs in Neurodegenerative Diseases: Current Evidence, Advances, and Opportunities

Quercetin: A Bioactive Compound Imparting Cardiovascular and Neuroprotective Benefits: Scope for Exploring Fresh Produce, Their Wastes, and By-Products

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