Profile on medicinal plants used by the people of North Eastern Morocco: Toxicity concerns

Kharchoufa, Loubna; Merrouni, Ilyass Alami; Yamani, Amal; Elachouri, Mostafa

doi:10.1016/j.toxicon.2018.09.003

Cited by 114 publications

(57 citation statements)

References 135 publications

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“…Despite the great phytotherapeutic importance of HS, the assessment of the safety or toxicity of this species has completely neglected; yet, it was cited, in a recent ethnobotanical investigation conducted by our team, as toxic [ 8 ]. In this respect, we undertook this work to assess the possible acute and subacute toxic effects of the aqueous extract of this plant.…”

Section: Introductionmentioning

confidence: 99%

Acute and Subacute Toxicity Studies of the Aqueous Extract from Haloxylon scoparium Pomel (Hammada scoparia (Pomel)) by Oral Administration in Rodents

Kharchoufa

Bencheikh

Assri

et al. 2020

BioMed Research International

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Ethnopharmacological Relevance. Haloxylon scoparium Pomel is a herbal medicine traditionally used for treating scorpions and snakebite, diabetes, and stomachache as well as several other diseases. No systematic study of the potential toxicity of the plant has been described. Aim of the Study. The current study is aimed at assessing the potential toxicity of Haloxylon scoparium Pomel through the acute and subacute toxicity tests. Materials and Methods. Acute toxicity test was performed on Swiss albino mice at a single oral dose of 1-10 g/kg for 14 consecutive days. General behavioral adverse effects, mortality, and latency of mortality were determined. In the subacute study, the Haloxylon scoparium Pomel extract was administered orally at doses of 500, 1000, and 2000 mg/kg daily for 30 days to Wistar rats. Body weight and selected biochemical and hematological parameters were determined at the end of the experiment. Sections of livers and kidneys were removed for histological studies. Results. Acute toxicity study showed that the oral LD50 value of Haloxylon scoparium Pomel extract was 5000 mg/kg. The subacute toxicity study of Haloxylon scoparium Pomel extract at doses 500, 1000, and 2000 mg/kg did not produce any observable symptoms of toxicity and no significant variation in body weight, organ weights, food, and water consumption or mortality in all treated rats. However, the administration of the Haloxylon scoparium Pomel extract to rats at 500 mg/kg and 1000 mg/kg showed a significant decrease in platelets. Moreover, only at the highest dose (2000 mg/kg), the extract caused a significant increase in red blood cells and hemoglobin. Our results showed that subacute treatments with Haloxylon scoparium Pomel extract at doses of 1000 mg/kg and 2000 mg/kg significantly elevated alkaline phosphatase and triglycerides. Histological studies showed that the subacute treatments of rats with Haloxylon scoparium Pomel extracts, at the doses 1000 and 2000 mg/kg, induced some histopathological changes in the livers but a slight changing in kidneys. Conclusion. Our results indicated low acute toxicity of the aqueous extract of Haloxylon scoparium Pomel. Furthermore, daily oral administration of Haloxylon scoparium Pomel extract caused some damages to the livers of rats treated with high doses, expressed by an increase in some enzyme activities such as ALP. Regarding the renal function, we did not find remarkable toxicity in the subacute treatment with Haloxylon scoparium Pomel extracts at doses 1000 and 2000 mg/kg. However, further toxicity assessments should be done to ascertain the safety or the toxicity of this valuable plant species “Haloxylon scoparium pomel” in subchronic treatments.

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Section: Introductionmentioning

confidence: 99%

Acute and Subacute Toxicity Studies of the Aqueous Extract from Haloxylon scoparium Pomel (Hammada scoparia (Pomel)) by Oral Administration in Rodents

Kharchoufa

Bencheikh

Assri

et al. 2020

BioMed Research International

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“…The main intoxication cause is the administration of contaminated plants [31]. The toxicity of the medicinal plants used in the north-east of Morocco is evaluated and it is reported that the species M. pulegium and M. spicata use can show adverse effects such as changes in reproductive performance and fetotoxicity for M. pulegium and abdominal muscle twitches, hyper-urination, convulsions, and lung tissue degeneration for M. spicata [43]. Despite these issues, phytotherapy is actually one main health care in Morocco since its efficacity is well proven [22].…”

Section: Ethnobotanical Surveysmentioning

confidence: 99%

Characterization, activities, and ethnobotanical uses of Mentha species in Morocco

Hassani

2020

Heliyon

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This work is a summary of the characterization, activities, and ethnobotanical surveys about aromatic and medicinal plants belonging to the genus Mentha in Morocco. The Mentha species investigated are Mentha pulegium, Mentha spicata, Mentha viridis, Mentha suaveolens, Mentha longifolia, Mentha gattefossei, Mentha rotundifolia, and Mentha vulgare, with M. pulegium being the most studied species. M. spicata and M. viridis are poorly explored even though they are daily consumed by Moroccans in tea infusions. The elucidated factors affecting the composition of Mentha essential oils are fertilization, drying conditions, mechanical impedance, NaCl stress, and Gamma irradiation. Investigation of the activities of the Mentha species showed that the main interest was dedicated to addressing the antibacterial effect towards gramþ and gram-bacteria. Essential oils of Mentha species exhibited antifungal, antiviral, antioxidant, insecticidal, licidal, niticidal, allelopathic, antidiabetic, derma-protective, and anticorrosive activities. The ethnobotanical surveys revealed that Mentha species are used in seven regions: Tafilalet, High Atlas, Fez-Boulemane, Taounat, Oujda, Ouazzane, and Rabat. By calculating the Jaccard index, the highest degree of similarity was found between Tafilalet, Rabat, and Oujda regions. The wide use of the Mentha species in Morocco highlights the high ethnobotanical value of the genus.

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“…C. maculatum extract is used as a traditional homeopathic remedy for cervix carcinoma (Mondal et al, 2014). This species has been used in ethnomedicine as an analgesic and antiinflammatory agent (De Landoni and Conium maculatum, 1990;Arihan et al, 2009;Al-Snafi, 2016,;Madaan and Kumar, 2012), in Turkey to treat diabetes (Paksoy et al, 2016), and in Morocco as an alternative to treat typhoid fever and sterility, and also to ease labor (Kharchoufa et al, 2018). Externally, it has been used to treat herpes and swelled joints (Bloch, 2001).…”

Section: Phytochemical Constituents and Ethnomedicinal Uses Of The Mementioning

confidence: 99%

“…The chemical composition of poison hemlock has been widely studied and the main toxic alkaloids are coniine and g-coniceine identified in all plant parts, but mostly in roots and seeds, and they are also responsible for the sedative and anti-inflammatory properties of the species (Vetter, 2004;Panter et al, 2011;Cortinovis and Caloni, 2015;Al-Snafi, 2016;Kharchoufa et al, 2018). Besides alkaloids, C. maculatum is rich in flavonoids (antioxidative), coumarins (anti-microbial, anti-inflammatory), polyacetylenes, vitamins, and oils (Al-Snafi, 2016).…”

Section: Phytochemical Constituents and Ethnomedicinal Uses Of The Mementioning

confidence: 99%

Turning Meadow Weeds Into Valuable Species for the Romanian Ethnomedicine While Complying With the Environmentally Friendly Farming Requirements of the European Union’s Common Agricultural Policy

Grosu

Ichim

2020

Front. Pharmacol.

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The cross-compliance mechanism of the European Union (EU)'s common agricultural policy (CAP) makes the approval of the direct payments to the European farmers subject to compliance with the requirement to maintain the land in good agricultural and environmental condition. One of the obligations of the Romanian land owners and farmers is to avoid the installation of unwanted vegetation on their land plots. This vegetation is represented by some species of herbaceous or woody plants, annual or perennial, that spontaneously invade the agricultural lands, diminishing the production capacity of the cultivated plants. Included in this category are 10 meadow weeds, without fodder value or even toxic to animals: Arctium lappa L., Carduus nutans L., Conium maculatum L., Eryngium campestre L., Euphorbia cyparissias L., Pteridium aquilinum (L.) Kuhn, Rumex acetosella L., Veratrum album L., Xanthium spinosum L., and Xanthium strumarium L. Various and multiple uses in traditional medicine of these meadow weed species have been reported for Romania and other nine neighboring East European countries, i.e.

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Profile on medicinal plants used by the people of North Eastern Morocco: Toxicity concerns

Cited by 114 publications

References 135 publications

Acute and Subacute Toxicity Studies of the Aqueous Extract from Haloxylon scoparium Pomel (Hammada scoparia (Pomel)) by Oral Administration in Rodents

Acute and Subacute Toxicity Studies of the Aqueous Extract from Haloxylon scoparium Pomel (Hammada scoparia (Pomel)) by Oral Administration in Rodents

Characterization, activities, and ethnobotanical uses of Mentha species in Morocco

Turning Meadow Weeds Into Valuable Species for the Romanian Ethnomedicine While Complying With the Environmentally Friendly Farming Requirements of the European Union’s Common Agricultural Policy

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