Profile of ocular and systemic characteristics in Möbius sequence patients from Brazil and Italy

Ventura, Bruna Vieira; Miller, Marilyn T.; Danda, Diana; Carta, Arturo; Brandt, Carlos Teixeira; Ventura, Liana

doi:10.1590/s0004-27492012000300011

Cited by 16 publications

(21 citation statements)

References 25 publications

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“…A previous study of patients with Mobius sequence reported a male: female ratio of 1.3:1, which was similar to the results of our study (31) . In the northeastern region of Brazil, the mothers of children with Möbius sequence took 600 to 2,800 µg of misoprostol between the fourth and sixth postfertilization week (7) .…”

Section: Discussionsupporting

confidence: 93%

“…In the present study, teratogens could be identified in most cases (56%), and 9.8% of the mothers were exposed to more than one teratogen. Furthermore, an isolated rubella infection during pregnancy was reported by one of the mothers.A previous study of patients with Mobius sequence reported a male: female ratio of 1.3:1, which was similar to the results of our study (31) . In the northeastern region of Brazil, the mothers of children with Möbius sequence took 600 to 2,800 µg of misoprostol between the fourth and sixth postfertilization week (7) .…”

supporting

confidence: 93%

“…In previous studies, the profiles of mothers of children with Mö-bius sequence that used misoprostol included the following characteristics: young age, low income, lower level of education, unstable marital status, and precarious access to the public health system (7,10,31) . The results of the present study agreed with these previous findings; the mothers that used misoprostol were generally younger and single or divorced.…”

Section: Discussionmentioning

confidence: 99%

“…The main recreational drugs used by these mothers were cigarettes and alcohol, although there were cases of marijuana and cocaine use. In contrast, another study of patients with Möbius sequence in northeastern Brazil reported that no cases were exposed to recreational drugs, cigarettes, alcohol, or rubella (7,31) . Brazil is a continental country with sociodemographic and regional differences that possibly justify this discrepancy.…”

mentioning

confidence: 99%

“…In the northeastern region of Brazil, the mothers of children with Möbius sequence took 600 to 2,800 µg of misoprostol between the fourth and sixth postfertilization week (7) . In the present study, the mothers of children with Möbius sequence in the southeastern region of Brazil reported that they took 400 μg to 2,400 μg of misoprostol between the second and fourteenth postfertilization week.In previous studies, the profiles of mothers of children with Mö-bius sequence that used misoprostol included the following characteristics: young age, low income, lower level of education, unstable marital status, and precarious access to the public health system (7,10,31) . The results of the present study agreed with these previous findings; the mothers that used misoprostol were generally younger and single or divorced.…”

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Teratogen exposure and congenital ocular abnormalities in Brazilian patients with Möbius sequence

Ventura¹,

Ventura²,

Miller³

et al. 2014

Arquivos Brasileiros De Oftalmologia

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Purpose: To assess the sociodemographic profiles, teratogen exposures, and ocu lar congenital abnormalities in Brazilian patients with Möbius sequence. Method: Forty-four patients were recruited from the Brazilian Möbius Sequence Society. This cross-section comprised 41 patients (age, mean ± standard deviation, 9.0 ± 5.5 years) who fulfilled the inclusion criteria. The parent or caregiver answered a questionnaire regarding sociodemographic data and pregnancy history. Patients underwent ophthalmological assessments. They were subdivided into groups according to misoprostol exposure during pregnancy, and the two groups were compared. Results: Mothers/caregivers reported unplanned pregnancies in 36 (88%) cases. Of these, 19 (53%) used misoprostol during their first trimesters. A stable marital status tended to be more frequent in the unexposed group (P=0.051). Incomplete elementary school education was reported by two (11%) mothers in the exposed group and by three (14%) mothers in the unexposed group (P=0.538). The mothers' gestational exposures to cocaine, marijuana, alcohol, and cigarettes were similar in both groups (P=0.297, P=0.297, P=0.428, and P=0.444, respectively). One (5%) case of Rubella infection during pregnancy was found in the unexposed group. The main malformations in the exposed and unexposed groups were the following: strabismus (72% and 77%, respectively), lack of emotional tearing (47% and 36%, respectively), and lagophthalmos (32% and 41%, respectively). Conclusions: Stable marital statuses tended to be more frequent among mothers that did not take misoprostol during pregnancy. Exposures to other teratogens and the main ocular abnormalities were similar in both groups. (P=0,297, P=0,297, P=0,428, P=0,444, respectivamente The use of abortive medications, such as misoprostol and certain herbal teas, are common in these countries (7,8) and are associated with congenital anomalies (7,(9)(10)(11) . Möbius sequence is a rare congenital disorder with an estimated prevalence in the general population of 1:500 to 1:5,000 newborns (7,12) . Although most cases are sporadic and some have been re- lated to genetic mutations (13)(14)(15) , intrauterine exposure to misoprostol and other teratogens has been associated with its occurrence (16)(17)(18)(19)(20)(21) . The aim of the present study was to report the sociodemographic profiles, teratogen exposures, and congenital abnormalities in patients with Möbius sequence. Keywords METHODSThis cross-sectional study followed the tenets of the Declaration of Helsinki and was approved by the Ethics Committee on Human Research of the Santa Casa de Misericórdia of São Paulo. Each patient and/or caregiver gave written informed consent before being included in the study. The data used in this study were collected by a multidisciplinary team from several institutions from North America (University of Illinois, Chicago) The Brazilian Möbius Syndrome Society is an association in southeastern Brazil for patients with Möbius sequence. The patients were recruited b...

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Section: Discussionsupporting

confidence: 93%

supporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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