Profile of hematological abnormalities of Indian HIV infected individuals

Dikshit, Byomakesh; Wanchu, Ajay; Sachdeva, Ravinder Kaur; Sharma, Aman; Das, Reena

doi:10.1186/1471-2326-9-5

Cited by 99 publications

(158 citation statements)

References 9 publications

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“…This reduced value may be due to the fact that immune systems of those not on antiretroviral therapies are more depressed or immunocompromised than the immune system of those not on ART, hence the lower value of PCV observed in them. This finding support the fact that ART improves Hematological parameters, hence the improved level of PCV on those on ART than on those not on ART (Amegor, 2009(Amegor, et al, 2009Byomakesh et al, 2009). …”

Section: Discussionsupporting

confidence: 78%

Evaluation of Pcv, Cd4+ T cell Counts, ESR and WBC Counts in Malaria Infected Symptomatic HIV (Stage 11) Male HIV/ Aids Subjects on Antiretroviral Therapy (Art) In Nnewi, South Eastern Nigeria

I.P¹

2012

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Section: Discussionsupporting

confidence: 78%

Evaluation of Pcv, Cd4+ T cell Counts, ESR and WBC Counts in Malaria Infected Symptomatic HIV (Stage 11) Male HIV/ Aids Subjects on Antiretroviral Therapy (Art) In Nnewi, South Eastern Nigeria

I.P¹

2012

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“…Another study showed that neutropenia was associated with CD4 and platelet counts; and that thrombocytopenia was associated with country, gender, and chronic hepatitis B infection (16). However, studies in India (17) and Rwanda (5) did not find a significant correlation between thrombocytopenia and low CD4 count. The differences in the prevalence and risk factors could be attributed to demographic characteristics, geographical location, cut-off values used to define the cytopenias, and different stages of HIV illness in the study populations.…”

Section: Discussionmentioning

confidence: 93%

A cross-sectional study of leukopenia and thrombocytopenia among Chinese adults with newly diagnosed HIV/AIDS

Shen

Wang

et al. 2015

BST

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“…5 We encountered bicytopenia in 20% (24/120) of cases and only one pancytopenia. Byomakesh Dikshit et al, 11 encountered Pancytopenia in 6% (12/200) of cases in their cohort study. Sitalakshmi et al, 13 and Spivak J et al, 14 also reported fewer cases of pancytopenia in their HIV cohort study group.…”

Section: Thrombocytopenia In Hivmentioning

confidence: 99%

Hematological abnormalities in HIV infected individuals in correlation to CD4 counts and ART status

Manimaran

Hemanathan

et al. 2016

Asian J Med Sci

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Background: HIV is pandemic and remains as a public health concern for many decades. This infection though associated with many opportunistic infections and neoplasms, it is further complicated with marked hematological abnormalities. The aim of this study is to determine the magnitude & severity of hematological abnormalities in HIV infected individuals and also to analyze these abnormalities in correlation with the CD4 counts. We also compared these hematological abnormalities in patients on ART and those not on ART.Materials and Methods: The study was conducted for a period of one year, on 120 HIV positive cases including both patients on ART & not on ART. Controls with similar age and sex distribution was set up. The blood samples were collected and processed in an automated cell counter. The parameters were tabulated and analyzed with respect to CD4 count & ART status.Results: Among the total of 120 HIV cases, 77% had anemia, 21% had leucopenia and 5% had thrombocytopenia. The magnitude and severity of anemia, leucopenia, thrombocytopenia and other parameters was found to be more in patients not on ART, when compared to patients on ART. Similarly, the magnitude and severity of most of hematological abnormalities were inversely proportional to the CD4 count in non-ART cases but not with cases on ART.Conclusion: The basic hematological parameters can be used as a prospective screening test to assess the severity and progression of HIV infection when CD4 count is not available. These parameters can also be used to assess the response to anti-retroviral treatment. Therefore, these basic hematological investigations readily available at all medical centers are of great use while treating HIV infected patients.Asian Journal of Medical Sciences Vol.7(4) 2016 14-18

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Profile of hematological abnormalities of Indian HIV infected individuals

Abstract: Background: Hematological abnormalities are a common complication of HIV infection. These abnormalities increase as the disease advances. Bone marrow abnormalities occur in all stages of HIV infection.

Cited by 99 publications

References 9 publications

Evaluation of Pcv, Cd4+ T cell Counts, ESR and WBC Counts in Malaria Infected Symptomatic HIV (Stage 11) Male HIV/ Aids Subjects on Antiretroviral Therapy (Art) In Nnewi, South Eastern Nigeria

Evaluation of Pcv, Cd4+ T cell Counts, ESR and WBC Counts in Malaria Infected Symptomatic HIV (Stage 11) Male HIV/ Aids Subjects on Antiretroviral Therapy (Art) In Nnewi, South Eastern Nigeria

A cross-sectional study of leukopenia and thrombocytopenia among Chinese adults with newly diagnosed HIV/AIDS

Hematological abnormalities in HIV infected individuals in correlation to CD4 counts and ART status

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