Profile of dermatophytosis in a tertiary care center in Kerala, India

Sheeja, S; Vineetha, Mary; Celine, MI; Sadeep, M S; Palackal, Seena; Shanimole, PE; Das, SSaranya

doi:10.4103/0019-5154.244812

Cited by 2 publications

(5 citation statements)

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“…Tinea corporis was the most common clinical type observed, involving around 34.34% of cases, which is similar to the studies by Agarwal et al [15], Vineetha et al [17], and Noronha et al [21], and features of both tinea cruris and tinea corporis were seen in 22.24% of cases. Tinea cruris variant was observed in 18.23% of cases.…”

Section: Cosupporting

confidence: 88%

“…In the current study, a family history of dermatophytosis was present in 27% of cases. A comparable result was also demonstrated in the studies by Mahajan et al [14], where a positive family history was present in 30.9% of cases, and Vineetha et al [17], where it was seen in 21%. Overcrowding and sharing of clothes, footwear, and combs were significant factors in the household transmission of dermatophytes.…”

Section: Cosupporting

confidence: 86%

“…People who work outdoors in hot and humid conditions are at significant risk of infection since it favors a suitable environment for the growth of dermatophytes. Many studies have reported that manual laborers are frequently affected [17,18]. Farmers also have increased risk due to exposure to fungus from the environment (soil and animals).…”

Section: Comentioning

confidence: 99%

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Current Status of Dermatophytosis: A Hospital-Based Study in Northern Odisha, India

Dalei,

Nayak,

Bhue

et al. 2023

Cureus

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Introduction Dermatophytosis is a superficial mycosis that affects the keratinized structures of skin, hair, and nails. In recent years, there has been a marked rise in superficial fungal infections in several parts of our country. Most of the cases are presented with chronic, recurrent, and resistant infections. There are no comprehensive data on the status of cases in our area. Currently, we have noticed a gradual decline in the number of cases in our day-to-day outpatient department compared to previous years. Therefore, the current retrospective study was conducted to assess the actual status and clinico-demographic trends of dermatophytosis among patients who visited the tertiary care hospital. Methods The current study is a retrospective study of 78,028 patients of dermatophytosis who reported to the tertiary care hospital. Data like demographic details, clinical examination findings, and laboratory investigation reports of patients were extracted from available records year-wise from 2018 to 2022. Results There was an initial rise of dermatophytosis until 2019 and, thereafter, a downward trend. Males (60.04%) outnumbered females (39.94%) with a proportion of 1.5:1. Most common age group belongs to 21-30 years (28.64%), of which a majority (53.07%) of patients had a disease duration of more than three months. The majority of patients (51.1%) belong to rural backgrounds, but there was urban predominance following the coronavirus disease (COVID-19) pandemic. The most common organism isolated from culture was Trichophyton mentagrophytes (61.98%) in the initial phases (2018 and 2019) and T. rubrum (31.67%) in the later phases (2020-2022). In the current study, a family history of dermatophytosis was present in 27% of cases. Tinea corporis was the most common (34.34%) clinical variant with atopic diathesis as a major co-morbidity (9.94%). Conclusion The findings of this study showed an initial increasing trend until 2019 and, thereafter, a downward trend. Therefore, similar types of studies may be carried out in different parts of the country to assess the actual status and, hence, a better and more efficient management of the disease.

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Section: Cosupporting

confidence: 88%

Section: Cosupporting

confidence: 86%

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Current Status of Dermatophytosis: A Hospital-Based Study in Northern Odisha, India

Dalei,

Nayak,

Bhue

et al. 2023

Cureus

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“…Physical labourers are the occupational group most typically impacted, according to recent studies. 18,19 92.2 % of the patients, who had their educational status examined were literate or higher, indicating an increased awareness about dermatophytosis that facilitated their proactive approach in seeking medical advice. Kaur et al reported the frequency of literate patients (64.6%) to be higher than that of illiterate patients (35.3%), which was similar to that observed in our study.…”

Section: Discussionmentioning

confidence: 99%

“…Due to their increased outside activity, labourers (29.7%) were the largest occupational group with infections. Physical labourers are the occupational group most typically impacted, according to recent studies 18,19 . 92.2 % of the patients, who had their educational status examined were literate or higher, indicating an increased awareness about dermatophytosis that facilitated their proactive approach in seeking medical advice.…”

Section: Discussionmentioning

confidence: 99%

Revisiting the pathogenesis of dermatophytosis: A cross‐sectional analytic study of serum levels of interleukins‐2, 8, 10 and 17

Dev

Bansal

Bhargava

2023

Mycoses

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BackgroundGiven the current epidemic‐like scenario of dermatophyte infections, it is prudent to revisit the immunopathogenesis of dermatophytosis. Comprehending the intricate interactions among interleukins can aid in understanding the recent trends in infection. There is a paucity of literature on the various cytokine levels observed in the serum of patients suffering from various dermatophytoses.AimTo study serum cytokine levels of interleukins 2, 8, 10 and 17 in patients with dermatophytosis.MethodsA cross‐sectional analytic study was conducted on 64 cases of clinical dermatophyte infections (KOH confirmed) and 64 controls. The clinico‐epidemiological profile of the cases was studied. By using a solid phase sandwich ELISA (enzyme‐linked immunosorbent assay), the serum levels of interleukins 2, 8, 10 and 17 were measured and compared between cases and controls. Serum interleukin‐2, 8, 10 and 17 levels were studied among cases based on mode of onset, duration of illness, treatment history, site of infection and multiple other morphological characteristics of the infection.ResultsThe cases had statistically higher levels of interleukins‐8, 10 and 17 in comparison with controls. The levels of interleukin‐8 were significantly lower (p < .05) among those who had received oral antifungals. In cases where the lesion had scaling, the serum levels of interleukin‐10 were significantly higher (p < .05). The lesional hyperpigmentation was significantly (p < .05) associated with low levels of interleukin‐17. Also, interleukin‐17 was significantly (p < .05) elevated in patients with lesions in the abdomen.ConclusionIt is the first time that serum interleukin levels are studied in dermatophytosis. There is an immunological dysfunction specific to dermatophytoses initiated by their infection. Key factor in this dysfunction is the elevation of IL‐10, contributing to persistent infection. In turn, causing an increase in IL‐17, promoting inflammation and tissue damage. This cycle of elevated IL‐10 and IL‐17 can further exacerbate the infection and lead to chronicity. The activity of IL‐2 and the Th1 immune pathway is reduced by two opposing immune pathways: the Th17 and Th2 axes.

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Profile of dermatophytosis in a tertiary care center in Kerala, India

Cited by 2 publications

References 0 publications

Current Status of Dermatophytosis: A Hospital-Based Study in Northern Odisha, India

Current Status of Dermatophytosis: A Hospital-Based Study in Northern Odisha, India

Revisiting the pathogenesis of dermatophytosis: A cross‐sectional analytic study of serum levels of interleukins‐2, 8, 10 and 17

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