Produits pharmaceutiques à visée hémostatique : physiopathologie, propriétés et utilisation

A new hemostatic agent composed of Zn2+-enriched Ca2+ alginate activates vascular endothelial cells in vitro and promotes tissue repair in vivo

“…Achieving good hemostasis at the end of a surgical intervention, in particular by controlling oozing due to capillary bleeding, is a major concern [ 1 , 2 ]. To control capillary bleeding, surgeons can apply absorbable hemostatic compresses, the most commonly used of which are Surgicel® (oxidized regenerated cellulose, Johnson & Johnson) and TachoSil® (human fibrinogen and human thrombin coated onto an equine collagen sponge, Takeda) [ 3 , 4 ]. Surgicel and TachoSil mechanically influence hemostasis by providing a framework for platelet aggregation; TachoSil also has a biological action as it promotes the formation of fibrin.…”