Production of stable quinine nanodispersions using esterified γ-polyglutamic acid biopolymer

Hoennscheidt, Christoph; Kreyenschulte, Dirk; Margaritis, Argyrios; Krull, Rainer

doi:10.1016/j.bej.2013.08.004

Cited by 7 publications

(7 citation statements)

References 39 publications

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“…γ-PGA has been utilized for the delivery of some category of drugs (Fig. 3) [12,18,22,[64][65][66][67][68][69].…”

Section: Characterization Of γ-Pga Nanoparticlesmentioning

confidence: 99%

“…The nanoparticle reportedly consists of a L-phenylalanine ethyl ester hydrophobic core and γ-PGA hydrophilic shell. This modification enhanced the loading and stability of the poorly water-soluble antimalarial, quinine [18]. Hydrophobic derivatives such as benzylamidated γ-PGA [16] are capable of assuming a stable helix structure with orderly arranged side chains on the outer edge, resulting in a rigid conformation [16,19,20].…”

Section: Introductionmentioning

confidence: 99%

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Drug delivery applications of poly-γ-glutamic acid

Balogun-Agbaje

Odeniyi

2021

Futur J Pharm Sci

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Background Poly-γ-glutamic acid (γ-PGA) is a biopolymer of microbial origin, consisting of repeating units of l-glutamic acid and/or D-glutamic acid. The biopolymer has found use in the fields of agriculture, food, wastewater, and medicine, owing to its non-toxic, biodegradable, and biocompatible properties. Due to its biodegradability, γ-PGA is being tipped to dislodge synthetic plastics in drug delivery application. High cost of production, relative to plastics, is however a clog in the wheel of achieving this. Main body of abstract This review looked at the production, nanoparticles fabrication, and drug delivery application of γ-PGA. γ-PGA production optimization by modifying the fermentation medium to tailor towards the production of desirable polymer at reduced cost and techniques for the formulation of γ-PGA nanoparticle as well as its characterization were discussed. This review also evaluated the application of γ-PGA and its nanoparticles in the delivery of drugs to action site. Characterization of γ-PGA and its nanoparticles is a crucial step towards determining the applicability of the biopolymer. γ-PGA has been used in the delivery of active agents to action sites. Conclusion This review highlights some of the efforts that have been made in the appraisal of γ-PGA and its nanoparticles for drug delivery. γ-PGA is a candidate for future extensive use in drug delivery.

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“…γ-PGA has been utilized for the delivery of some category of drugs (Fig. 3) [12,18,22,[64][65][66][67][68][69].…”

Section: Characterization Of γ-Pga Nanoparticlesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Drug delivery applications of poly-γ-glutamic acid

Balogun-Agbaje

Odeniyi

2021

Futur J Pharm Sci

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“…They can be prepared using a large variety of biodegradable and biocompatible polymers, with different characteristics of resistance and permeability, generating nanoparticles capable of carrying and modulating the release of drugs while protecting them from the medium, pH, light, and enzymatic degradation [152][153][154][155]. Polymeric nanocapsules have presented promising results for administration of antimalarials, improving their efficacy, as demonstrated in several in vivo studies [156][157][158][159][160]. For example, polymeric polyvinylpyrrolidone 10 (PVP 10), l-α-phosphatidylcholine, polysorbate 80, and Poloxamer 407 nanoparticles were used to encapsulate decoquinate (DQ), a new antimalarial candidate.…”

Section: Formulation Techniquesmentioning

confidence: 99%

Porphyrin Derivative Nanoformulations for Therapy and Antiparasitic Agents

et al. 2020

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Porphyrins and analogous macrocycles exhibit interesting photochemical, catalytic, and luminescence properties demonstrating high potential in the treatment of several diseases. Among them can be highlighted the possibility of application in photodynamic therapy and antimicrobial/antiparasitic PDT, for example, of malaria parasite. However, the low efficiency generally associated with their low solubility in water and bioavailability have precluded biomedical applications. Nanotechnology can provide efficient strategies to enhance bioavailability and incorporate targeted delivery properties to conventional pharmaceuticals, enhancing the effectiveness and reducing the toxicity, thus improving the adhesion to the treatment. In this way, those limitations can be overcome by using two main strategies: (1) Incorporation of hydrophilic substituents into the macrocycle ring while controlling the interaction with biological systems and (2) by including them in nanocarriers and delivery nanosystems. This review will focus on antiparasitic drugs based on porphyrin derivatives developed according to these two strategies, considering their vast and increasing applications befitting the multiple roles of these compounds in nature.

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“…A study by Hoennscheidt et al, 2013 [ 99 ] has found that the drug quinine was encapsulated partially with γ-PGA of a high molecular weight made from B. licheniformis . This drug (Quinine) is known to be the most popular anti-malarial drug linked with very severe side effects when overdosed.…”

Section: Medical Applications Of γ-Pga-based Micro/nanoparticlesmentioning

confidence: 99%

“…This drug is not effectively water-soluble; it works in a prototypical manner to many hydrophobic drugs. Steady distributions were made through the use of a technique based on solvent evaporation and other characteristics [ 99 ]. For acquired immunodeficiency syndrome (AIDS) treatment, the drug Saquinavir (SQV) is used as a protease inhibitor.…”

Section: Medical Applications Of γ-Pga-based Micro/nanoparticlesmentioning

confidence: 99%

Bacterial-Derived Polymer Poly-y-Glutamic Acid (y-PGA)-Based Micro/Nanoparticles as a Delivery System for Antimicrobials and Other Biomedical Applications

Khalil

Burns

Radecka

et al. 2017

IJMS

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In the past decade, poly-γ-glutamic acid (γ-PGA)-based micro/nanoparticles have garnered remarkable attention as antimicrobial agents and for drug delivery, owing to their controlled and sustained-release properties, low toxicity, as well as biocompatibility with tissue and cells. γ-PGA is a naturally occurring biopolymer produced by several gram-positive bacteria that, due to its biodegradable, non-toxic and non-immunogenic properties, has been used successfully in the medical, food and wastewater industries. Moreover, its carboxylic group on the side chains can offer an attachment point to conjugate antimicrobial and various therapeutic agents, or to chemically modify the solubility of the biopolymer. The unique characteristics of γ-PGA have a promising future for medical and pharmaceutical applications. In the present review, the structure, properties and micro/nanoparticle preparation methods of γ-PGA and its derivatives are covered. Also, we have highlighted the impact of micro/nanoencapsulation or immobilisation of antimicrobial agents and various disease-related drugs on biodegradable γ-PGA micro/nanoparticles.

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Production of stable quinine nanodispersions using esterified γ-polyglutamic acid biopolymer

Cited by 7 publications

References 39 publications

Drug delivery applications of poly-γ-glutamic acid

Drug delivery applications of poly-γ-glutamic acid

Porphyrin Derivative Nanoformulations for Therapy and Antiparasitic Agents

Bacterial-Derived Polymer Poly-y-Glutamic Acid (y-PGA)-Based Micro/Nanoparticles as a Delivery System for Antimicrobials and Other Biomedical Applications

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